77 research outputs found
Lack of association between ventricular pacing and ventricular tachyarrhythmias episodes prompting ICD intervention in a MADIT II-like population: the SEARCH-MI registry preliminary results
No full textMADIT II indication in clinical practice: two years experience from the Search-MI registry
No full textPrimary prevention of sudden death in post-infarction patients using cardioverter-defibrillators: results on 444 patients from a multicenter national registry
No full textCritique of stoicism in the text of J. M. von Loën "Epicurische Sittenlehre die beste" (1751)
No full textDer vorliegende Aufsatz ist ein Beitrag zur Erforschung der Kritik des Stoizismus im 18. Jahrhundert in Deutschland. Die Autorin weist darauf hin, dass Johann Michael von Loëns Text der von Christian Thomasius initiierten und von Alexander Gottlieb Baumgarten sowie Georg Friedrich Meier weiterentwickelten Strömung einer kritischen Aufnahme des stoischen Gedankenguts zuzurechnen ist. Die Terminologie, die von Loën anwendet, verweist auf evidenten genetischen Zusammenhang mit der Terminologie Baumgartens („rauhe Sittenlehre/Tugend“), die Argumentation dagegen auf ein argumentatives Bemühen Meiers, der das stoische Postulat, der Mensch müsse die Emotionen unterdrücken bzw. vertilgen, vehement abgelehnt hat. Von Loën ist – genauso wie Meier – ein Anhänger der Konzeption des ganzen Menschen und er plädiert für das Ideal einer Harmonie von Geist und Körper („Gemütsruhe“).Artykuł jest przyczynkiem do badań nad krytyką stoicyzmu w XVIII wieku. Autorka wskazuje, że tekst Johanna Michaela von Loëna wpisuje się w trend zainicjowany przez Thomasiusa, który został rozwinięty przez Baumgartena i Meiera. Terminologia, jakiej używa von Loën, ewidentnie wykazuje genetyczne związki z terminologią Baumgartena („rauhe Sittenlehre/Tugend”), a krytyczna argumentacja ma związek z argumentacją Meiera, który stoicki postulat tłumienia emocji nazwał pozbawieniem człowieka połowy człowieczeństwa. Von Loën – podobnie jak Meier – jest zwolennikiem koncepcji „całego człowieka” („der ganze Mensch”) i optuje za ideałem harmonii ducha („Gemütsruhe”).This article is a contribution to analysis of the critique of stoicism in the 18th century. The author suggests that the text of J. M. von Loën is intertwined with the trend initiated by Thomasius that was developed by Baumgarten and Meier. The terminology that is used by von Loën evidently suggests genetic connotations with the terminology used by Baumgarten (“rauhe Sittenlehre/Tugend”), and the critical argumentation has the connection with the argumentation used by Meier, who has termed the stoic postulate of stifling emotions as a removal of half of humankind from a human being. Von Loën – similarly to Meier – is a proponent of the concept of a whole human being (“der ganze Mensch”) and he opts for the harmony of the soul (“Gemütsruhe”)
Cryoballoon or radiofrequency ablation? Alternating technique for repeat procedures in patients with atrial fibrillation
No full textBackground: Which technique is better for repeat ablation in patients with atrial fibrillation (AF) remains unclear. The aim of the study was to compare long-term efficacy of repeat ablation using the alternative technique for the first redo ablation procedure: (a) cryoballoon (CB) re-ablation after a failed index pulmonary vein isolation (PVI) with radiofrequency (RF) ablation, RF-then-CB group or (b) RF repeat ablation following a failed CB ablation, CB-then-RF group. Methods: Within the 1STOP Italian Project, consecutive patients undergoing repeat ablation with a different technique from the index procedure were included. Results: We studied 474 patients, 349 in RF-then-CB and 125 in CB-then-RF group. Less women (21% vs 30%; P =.041), more persistent AF (33% vs 22%; P =.015), longer duration of AF (60 vs 31 months; P <.001), and more hypertension (50% vs 36%; P =.007) were observed in the RF-then-CB cohort as compared with the CB-then-RF group. The number of reconnected PVs was 3.7 ± 0.7 and 1.4 + 1.3 in RF-then-CB and CB-then-RF group, respectively (P <.001). During the follow-up, significantly less AF recurrence occurred in the CB-then-RF group (22% vs 8%, HR = 0.46; 95% CI: 0.24-0.92; P =.025). Cohort designation was the only independent predictor of AF recurrence. Conclusion: Alternation of energy source for repeat ablation was safe and effective, regardless the energy used first. However, patients initially treated with CB PVI undergoing repeat ablation with RF current had less AF recurrence at long-term follow-up as compared with those originally treated by RF ablation receiving a CB repeat ablation
Generation and characterization of three human induced pluripotent stem cell lines (EURACi007-A, EURACi008-A, EURACi009-A) from three different individuals of the same family with arrhythmogenic cardiomyopathy (ACM) carrying the plakophillin2 p.N346Lfs*12 mutation
No full textArrhythmogenic Cardiomyopathy (ACM) is a genetically based cardiomyopathy associated with ventricular arrhythmias and fibro-fatty substitution of cardiac tissue. It is characterized by incomplete penetrance. We generated human iPSCs by episomal reprogramming of blood cells from three members of the same family: the proband, affected by ACM and carrying the heterozygous plakophillin2 p.N346Lfs*12 mutation, one asymptomatic carrier of the same mutation and one apparently healthy control. hiPSCs were characterized according to standard protocols including karyotyping, pluripotency marker expression and differentiation towards the three germ layers. These hiPSC lines can be used to study the mechanisms of ACM incomplete penetrance in vitro
Clinical and arrhythmic outcomes after implantation of a defibrillator for primary prevention of sudden death in patients with post-myocardial infarction cardiomyopathy: The Survey to Evaluate Arrhythmia Rate in High-risk MI patients (SEARCH-MI)
No full textTo evaluate clinical and arrhythmic outcomes in post-infarction cardiomyopathy patients implanted with a defibrillator (ICD) for primary prevention of sudden death
Exploring digenic inheritance in arrhythmogenic cardiomyopathy
No full textBackground: Arrhythmogenic cardiomyopathy (ACM) is an inherited genetic disorder, characterized by the substitution of heart muscle with fibro-fatty tissue and severe ventricular arrhythmias, often leading to heart failure and sudden cardiac death. ACM is considered a monogenic disorder, but the low penetrance of mutations identified in patients suggests the involvement of additional genetic or environmental factors. Methods: We used whole exome sequencing to investigate digenic inheritance in two ACM families where previous diagnostic tests have revealed a PKP2 mutation in all affected and some healthy individuals. In family members with PKP2 mutations we determined all genes that harbor variants in affected but not in healthy carriers or vice versa. We computationally prioritized the most likely candidates, focusing on known ACM genes and genes related to PKP2 through protein interactions, functional relationships, or shared biological processes. Results: We identified four candidate genes in family 1, namely DAG1, DAB2IP, CTBP2 and TCF25, and eleven candidate genes in family 2. The most promising gene in the second family is TTN, a gene previously associated with ACM, in which the affected individual harbors two rare deleterious-predicted missense variants, one of which is located in the protein's only serine kinase domain. Conclusions: In this study we report genes that might act as digenic players in ACM pathogenesis, on the basis of co-segregation with PKP2 mutations. Validation in larger cohorts is still required to prove the utility of this model
Rozwój opieki nad dzieckiem w pedagogicznej teorii i praktyce Niemiec (XIX wiek – początek XX wieku)
No full textThe article describes the development of childcare against the social and political background of Germany in the 19th–early 20th centuries. Care embraces different social forms, in particular that of philanthropy, giving paramount significance to charity and assisstance, becomes associated with the reform movement, concentrated around humanistic ideas of the community. The origin and functioning of forms of institutional care, including Johann Wichern’s "rough houses", Hermann Lietz’s homes of learning, Eva-Marie Tiele-Winckler’s "children’s homes" have been analyzed where teachers were considered paragons of caregiving-related activities benefitting the child. Educational activities of the abovementioned institutions was designed to meet children’s needs, develop an active, creative, responsible, independent child who would be able to find its place in life and live in harmony with itself and the outer world.Artykuł opisuje rozwój opieki nad dzieckiem w kontekście życia społeczno-politycznego w Niemczech w XIX i na początku XX wieku. Opieka ujmowana jest w różny sposób, ma formę filantropii, dając pierwszoplanowe znaczenie idei miłosierdzia i pomocy bliskim, związana jest z ruchem reformatorskim lub skoncentrowana wokół humanistycznych idei wspólnoty ludzkiej. W niniejszym artykule dokonano analizy pochodzenia i funkcjonowania instytucjonalnych form opieki, w szczególności szkołę-przytułek (Das Rauhe Haus) Johanna Wicherna, budynki wychowawcze Hermana Litza oraz „domy dziecka” Ewy-Marii Thiele-Winkler. Ci wybitni pedagodzy byli przykładem podejścia opiekuńczego, zwracali oni uwagę na to, by opieka odpowiadała idei dobra dziecka. Działalność opiekuńczo-wychowawcza tych instytucji została zaprojektowany w celu zaspokojenia potrzeb dziecka, rozwoju aktywności, kreatywności, odpowiedzialności za realizację działań, zdolności do samodzielnego podejmowania decyzji, znalezienia swojego miejsca w życiu i życia w harmonii ze sobą i światem
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