549 research outputs found
“Immunohistochemical Localization of Leptin in Adipose Tissues” in coll.
No full text“Immunohistochemical Localization of Leptin in Adipose Tissues” in coll. R. DeMatteis, M.C. Zingaretti and J. Himms-Hagen. In: Leptin the voice of Adipose Tissue. Ed. by W.F. Blum, W. Kiess, W Rascher . , 199
Gender differences in leptin plasma levels in obese people and its relationship with plasma testosterone and insulin sensitivity
No full textAngela Rascher, Schriftauslegung und Christologie im Hebräerbrief, (Beihefte zur Zeitschrift für die neutestamentliche Wissenschaft, 153) Berlin – New York, W. de Gruyter, 2007
No full textGrappe Christian. Angela Rascher, Schriftauslegung und Christologie im Hebräerbrief, (Beihefte zur Zeitschrift für die neutestamentliche Wissenschaft, 153) Berlin – New York, W. de Gruyter, 2007. In: Revue d'histoire et de philosophie religieuses, 88e année n°3, Juillet-Septembre 2008. pp. 384-385
Angela Rascher, Schriftauslegung und Christologie im Hebräerbrief, (Beihefte zur Zeitschrift für die neutestamentliche Wissenschaft, 153) Berlin – New York, W. de Gruyter, 2007
No full textGrappe Christian. Angela Rascher, Schriftauslegung und Christologie im Hebräerbrief, (Beihefte zur Zeitschrift für die neutestamentliche Wissenschaft, 153) Berlin – New York, W. de Gruyter, 2007. In: Revue d'histoire et de philosophie religieuses, 88e année n°3, Juillet-Septembre 2008. pp. 384-385
A Test of the Optimal Positive Production Network Externality in Major League Baseball
No full textUnlike most businesses, firms in a sports league need viable competitors. While a certain amount of domination is optimal, from an individual owners perspective, too much will result in league dissolution, and thus a lower utility for every owner. Hence, there is a limited positive production network externality. This paper examines the optimal level of the externality in professional baseball using data from each game of the 1996 MLB season. Both absolute and relative quality are important determinants of the demand for sports contests. In fact, fans prefer a game in which two high quality teams are competing, but the home team has approximately twice as good of a chance as the visiting team of winning.uncertainty of outcome; censored regression; cluster correlation; demand; baseball; network externality
Illustrations of Price Discrimination in Baseball
No full textPrice discrimination of this nature, focused on differing degrees of quality, bundled goods, volume discounts, and other forms of second-degree price discrimination, is commonplace in MLB. Indeed, it is safe to say that every single MLB ticket is sold under some form of price discrimination. As teams grow increasingly sophisticated in their pricing strategies, price discrimination is becoming more precise, more wide-spread, and more profitable, while at the same time providing for more opportunities for more fans to find tickets at a price they are willing to pay. Unlike a baseball game, where one team must lose and one must win, price discrimination allows for win-win economic outcomes for teams and fans alike.price discrimination; bundling; variable pricing; dynamic pricing; secondary ticketing; two-part tariff; loaded ticket
Plasma arginine vasopressin concentrations in epileptics under monotherapy
No full textPlasma arginine vasopressin concentrations were determined by radio-immunoassay in 112 adult epileptics who were taking carbamazepine, phenytoin, primidone, or sodium valproate in long-term monotherapy, and in 19 controls. No significant difference was found between the groups, but some epileptics taking carbamazepine and primidone showed low values. Serum
concentrations of carbamazepine did not correlate with the concentrations of plasma arginine vasopressin.
In conclusion, there was no evidence of a stimulating
effect of chronic carbamazepine medication or a special inhibiting effect of phenytoin on the release of vasopressin arginine from the posterior pituitary
Do Fans Want Close Contests? A Test of the Uncertainty of Outcome Hypothesis in the National Basketball Association
No full textThe National Basketball Association claims to sell entertainment. Part of that entertainment is close, competitive contests with uncertain outcomes. However, hometown fans want the home team to win. Hence, the optimal probability that the home team wins a game, from the perspective of maximizing demand, lays somewhere between 0.5 and 1.0. Using data from individual games for the 2001-02 season, this optimal probability was estimated to be approximately 0.66. Fans want their home team to have about twice the chance to win a game as the visiting team.uncertainty of outcome; basketball; linear regression; home court advantage; demand; attendance
Suppression von Interleukin 8, Cyclooxygenase 2, Prostaglandin E 3-Rezeptor und Prostaglandinen durch Parecoxib und Indometacin imTiermodell der neonatalen B- Streptokokkensepsis
No full textGroup B streptococcus infections in the neonatal period can cause a severe sepsis. Initially, unspecific symptoms such as pallor, lethargy and decreased peripheral blood flow lead to a rapid progression and shock and make an early effective therapy to improve outcomes necessary. The purpose of the study was to determine the effect of the inhibition of prostaglandin synthesis on the course of the experimental B streptococci sepsis in animal models. Inhibition of prostaglandin synthesis was carried out with Indomethacin and specific COX 2 inhibitor Parecoxib. In addition to the hemodynamics, inflammatory mediators such as IL 8, COX 2, EP 3 receptor and various prostaglandins in the urine were examined. Newborn piglets under anesthesia were randomized into different groups(infection with streptococcus group B, infection with streptococcus group B + indomethacin, infection with streptococcus group B + parecoxib and control group without infection and therapy). Due to monitoring of MAP, MPAP and urine, the piglets got catheters for invasively measurement. After the observation time all pigs were killed and lung tissue for the isolation of the gene expression (mRNA) of various inflammatory markers was taken and measured by quantitative PCR. In addition prostaglandin metabolites in the urine were quantified by mass spectrometry. The COX 2, EP 3 and IL 8- mRNA expression in lung tissue were quantified by TaqMan PCR. Indomethacin and Parecoxib prevented the increase of the mRNA expression of all markers as well. The urine analysis demonstrated that the drug effect on thromboxane metabolites differed. Parecoxib treatment did not affect thromboxane formation. After intravenous infusion of GBS MAP decreased continously, neither Indometacin nor Parecoxib could prevent arterial hypotension. The infection induced rise of MPAP however was prevented by both pharmaceuticals. Both drugs had a positive influence on the pulmonal hemodynamics, as well as the prevention of the inflamemation of the lungs. On the other hand both could not avoid the decrease of system- arterial blood pressure. While during the application of Indomethacin and Parecoxib a comparable inhibition of the EP 3 receptor and the MPAD were achieved, only the application of indomethacin caused a significant inhibition of thromboxane synthesis.Infektionen mit B- Streptokokken im Neugeborenenalter zur neonatalen B- Streptokokkensepsis führen. Unspezifische Symptome führen zu einer raschen Progredienz, zum Schock und erfordern eine frühzeitige effektive Therapie, um das Outcome zu verbessern. Ziel der Arbeit war es, die Wirkung einer Hemmung der Prostaglandinsynthese auf den Verlauf der experimentellen B- Streptokokkensepsis am Tiermodell zu untersuchen. Die Hemmung der Prostaglandinsynthese erfolgte mit Indometacin und dem spezifischen Cyclooxygenase 2 Inhibitor Parecoxib. Neben der Hämodynamik wurden die Entzündungsmediatoren Interleukin 8, Cyclooxygenase 2, der Prostaglandinrezeptor E 3 und verschiedene Prostaglandine im Urin untersucht. Neugeborene Schweine wurden unter Narkose nach Anlage von Kathetern zur intraarteriellen Messung des mittleren arteriellen Blutdruckes, des mittleren pulmonal arteriellen Druckes und nach Anlage eines Blasenkatheters in 4 Gruppen randomisiert (Infektion mit Streptokokken der Gruppe B, Infektion mit Streptokokken der Gruppe B + Indometacin, Infektion mit Streptokokken der Gruppe B + Parecoxib, Kontrollgruppe ohne Infektion und Therapie). Während des Versuches wurde invasiv der MAD und der MPAD gemessen. Am Ende des Versuches wurden die Tiere getötet, Lungengewebe zur Isolierung der Genaktivität (mRNA) verschiedener Entzündungsmarker entnommen und mittels quantitativer PCR gemessen. Zudem wurden Prostaglandinmetabolite im Urin der Tiere massenspektrometrisch quantifiziert. Die Untersuchungen an dem entnommenen Lungengewebe zeigten, dass die Gabe von Indometacin beziehungsweise Parecoxib sowohl die Expression der IL 8 und EP 3- mRNA, als auch von COX 2- mRNA und der Thromboxansynthese supprimiert. Im Urin zeigte sich, dass beide Medikamente die Ausscheidung der Prostaglandine unterschiedlich beeinflussen. Auf die Ausscheidung des Thromboxans hatte Parecoxib im Vergleich zu Indomentacin keinen Einfluss. Weder Indometacin noch Parecoxib konnten den Abfall des MAD längerfristig verhindern, aber sie senkten den MPAD. Beide Medikamente haben sowohl auf die Hämodynamik, als auch auf die Entzündungsreaktion der Lunge einen positiven Einfluss, verhindern aber nicht den Abfall des system- arteriellen Blutdrucks. Während durch die Anwendung von Indometacin und Parecoxib eine vergleichbare Hemmung des Prostaglandinrezeptors E 3 erfolgt und der MPAD abgesenkt wurde, bewirkt nur die Gabe von Indometacin eine deutliche Inhibition der Thromboxansynthese
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