2,950 research outputs found

    Melanoma-associated adhesion molecule MUC18/MCAM (CD146) and transcriptional regulator Mader in normal human CNS

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    The proteins MUC18 and Mader have been identified as markers of tumor progression in melanoma cells, MUC18, also known as MCAM (melanoma cell adhesion molecule) and as CD146 (endothelial antigen), is a cell adhesion molecule belonging to the immunoglobulin superfamily, Mader is a transcriptional regulator shown to negatively regulate EGR-1. As it is known that neoplastic cells of neuroectodermal origin frequently express neuron-specific molecules, we studied whether these melanoma-associated antigens are found in normal CNS tissue. We investigated the expression of MUC18/MCAM and Mader in adult human post mortem CNS tissue by immunohistochemistry, immunoblot and two-dimensional gel electrophoresis. Our results show that Mader is preferentially expressed on neurons and glial cells and that the adhesion protein MUC18/MCAM is mainly expressed on vasculature within the CNS. These observations may have important implications for further studies investigating their possible roles in cell adhesion and proliferation control within the CNS

    Die Schlacht bei Tanga : Erzählung aus dem Weltkrieg

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    von Fr. W. Mader ; mit Zeichnungen von Karl MühlmeisterSchriftenreihe des Originals: Spannende Geschichten ; 3

    Henry William Mader, (1863-1943), purchased by Mr. Elmer W. Hinkleman on May 14, 1945.

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    Documents regarding the headstone for Henry William Mader, (1863-1943), purchased by Mr. Elmer W. Hinkleman. The marker was placed at Memorial Park Cemetery, Lot 103, Section 1 in Sylvania, Ohio. The stone is made of Rock of Ages with Polished Flat Top Balance Rock in Sandblast letters

    Der Markt für Hedgefonds-Zertifikate in Deutschland

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    Der Markt für Hedgefonds-Zertifikate in Deutschland / W. Mader, C. Echter. - In: FinanzBetrieb. 6. 2004. S. 612-61

    Basel II - Mindestkapitalanforderungen: Alternativen bei der Unterlegung von Verbriefungen

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    Basel II - Mindestkapitalanforderungen: Alternativen bei der Unterlegung von Verbriefungen / W. Mader, C. Miehle. - In: Zeitschrift für das gesamte Kreditwesen. 59. 2006. S. 232-24

    Susan Mader and Eric Ripley at First Secularized Board of Governors Meeting, 1970

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    b&w photographExcellent condition: curling a bit, on back: 'to 29 1/2 picas', and on bottom border, 'Members of new board, page 4 82% Journal'.Board members Lawrence Hayes (left, of Halifax law firm McInnes, Cooper & Robertson), Susan Mader (Arts class of 1971, SRC Secretary), and Eric Ripley (Science class of 1970, SRC Science rep, with mutton chop whiskers!) stand talking during Saint Mary's first secularized Board of Governors meeting.Susan Mader was the first woman to sit on the Board

    Epilachna ocellataemaculata Mader 1930

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    Epilachna ocellataemaculata (Mader, 1930) (Figs. 16 a–h) Specimens examined. Hubei: Shennongjia Net Res, 1998.vi. 1–5, Bolm (1, NHMB). Yunna: Yulongshan, Baishui, 1990.vii. 7–12, D. Král (1, NHMB); Lijiang, 1990.vi. 30 –vii. 2, Lad. Bocák (10, NHMB); Kunming, Western Hills, 1990.vii. 9, Lad. Bocák (5, NHMB); Xishan, 1993.vi. 27, Bolm (1, NHMB); Dongchuan, 1994.vi. 28 –vii. 3, Vit Kubáň (1, NHMB). Sichuan: Moxi, Hailuogou, 1994.vii. 1–7, J. Farkač & D. Král (3, NHMB). Guizhou: Leigongshan, 1983.vii. 13–15, Chen Zhenyao (2, SYSM); Daozhen, Sanqiaozhen, 2004.v. 22–24; Dashanhe, 2004.v. 29–31, Song Qiongzhang (2, SYSM). Remarks. Male genitalia of E. ocellataemaculata and E. plicata are almost identical (Figs. 16, 17) but both species can easily be distinguished externally by a peculiar elytral color pattern (Figs. 16 a, 17 a) and subapical ‘plica” in E. plicata (Fig. 17 b).Published as part of Pang, Hong, Ślipiński, Adam, U, Yap Ing W & Zuo, Yongsheng, 2012, Contribution to the knowledge of Chinese Epilachna Chevrolat with descriptions of new species (Coleoptera: Coccinellidae: Epilachnini), pp. 1-37 in Zootaxa 3420 (1) on pages 20-21, DOI: 10.11646/zootaxa.3420.1.1, http://zenodo.org/record/28196

    Critical vertices in k-connected digraphs

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    It is proved that every non-complete, finite digraph of connectivity number k has a fragment F containing at most k critical vertices. The following result is a direct consequence: every k-connected, finite digraph D of minimum out- and indegree at least 2k+m−1 for positive integers k, m has a subdigraph H of minimum outdegree or minimum indegree at least m−1 such that D−x is k-connected for all x∈V(H). For m=1, this implies immediately the existence of a vertex of indegree or outdegree less than 2k in a k-critical, finite digraph, which was proved in Mader (J Comb Theory (B) 53:260–272, 1991). The final publication is available at Springer via https://doi.org/10.1007/s12188-016-0173-y

    On k-con-Critically n-Connected Graphs

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    AbstractWe prove that every n-connected graph G of sufficiently large order contains a connected graph H on four vertices such that G−V(H) is (n−3)-connected. This had been conjectured in Mader (High connectivity keeping sets in n-connected graphs, Combinatorica, to appear). Furthermore, we prove upper bounds for the order of all n-connected graphs of criticality 3, 4, and 5

    FAT DELTA 2: FUNCTORIAL SUBGROUPS OF TOPOLOGICAL ABELIAN GROUPS

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    In the predecessor [16] of this paper the canonical subgroup (Fat Delta) ∆(G) of a compact abelian group G was studied. It is the sum of all closed disconnected subgroups of G and it appeared before in the literature (see [28]) as td(G), defined for arbitrary topological groups and motivated by completely different considerations. We introduce and compare further functorial subgroups of general topological groups and study their relationships with ∆(G) and td(G)
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