5,477 research outputs found
Handwritten note by Judge Michael J. Roche
No full textNote by United States District Judge Michael J. Roche: "Filed July 2, 1943 In the above-entitled cause it appearing upon the face of the petition that petitioner is not entitled to a writ of habeas corpus, and it further appearing that she has not exhausted her administrative remedies under the provisions of Executive Order No. 9102 (7 Fed. Reg. 2165) and the regulations promulgated thereunder, IT IS THEREFORE ordered that the petition for a write of habeas corpus be, and the same is, hereby denied, dated: July 2, 1943." Note is written on the back of a document titled "Statement of Oswald Garrison Villard on Chinese Exclusion before the H. R. Committee on Immigration and Naturalization on May 20, 1943."The ACLU-Northern California case file records contain legal documents and correspondence pertaining to the case Ex parte Mitsuye Endo (1944), in which the United States Supreme court unanimously ruled that the federal government could not indefinitely detain United States citizens who were loyal to the government. Files include documents related to the Gordon Hirabayashi Supreme Court case Hirabayashi v. United States
From classroom tutor to hypertext adviser: An evaluation
No full textThis paper describes a three‐year experiment to investigate the possibility of making economies by replacing practical laboratory sessions with courseware while attempting to ensure that the quality of the student learning experience did not suffer. Pathology labs are a central component of the first‐year medical undergraduate curriculum at Southampton. Activities in these labs had been carefully designed and they were supervised by lab demonstrators who were subject domain experts. The labs were successful in the eyes of both staff and students but were expensive to conduct, in terms of equipment and staffing. Year by year evaluation of the introduction of courseware revealed that there was no measurable difference in student performance as a result of introducing the courseware, but that students were unhappy about the loss of interaction with the demonstrators. The final outcome of this experiment was a courseware replacement for six labs which included a software online hypertext adviser. The contribution of this work is that it adds to the body of empirical evidence in support of the importance of maintaining dialogue with students when introducing courseware, and it presents an example of how this interaction might be achieved in software
QTrim : a novel tool for the quality trimming of sequence reads generated using the Roche/454 sequencing platform
No full textBackground
Many high throughput sequencing (HTS) approaches, such as the Roche/454 platform, produce sequences in which the quality of the sequence (as measured by a Phred-like quality scores) decreases linearly across a sequence read. Undertaking quality trimming of this data is essential to enable confidence in the results of subsequent downstream analysis. Here, we have developed a novel, highly sensitive and accurate approach (QTrim) for the quality trimming of sequence reads generated using the Roche/454 sequencing platform (or any platform with long reads that outputs Phred-like quality scores).
Results
The performance of QTrim was evaluated against all other available quality trimming approaches on both poor and high quality 454 sequence data. In all cases, QTrim appears to perform equally as well as the best other approach (PRINSEQ) with these two methods significantly outperforming all other methods. Further analysis of the trimmed data revealed that the novel trimming approach implemented in QTrim ensures that the prevalence of low quality bases in the resulting trimmed data is substantially lower than PRINSEQ or any of the other approaches tested.
Conclusions
QTrim is a novel, highly sensitive and accurate algorithm for the quality trimming of Roche/454 sequence reads. It is implemented both as an executable program that can be integrated with standalone sequence analysis pipelines and as a web-based application to enable individuals with little or no bioinformatics experience to quality trim their sequence data
Spostrzezenia nad skutecznoscia ornidazolu [Tiberal La Roche] w leczeniu giardiozy
No full textOrnidazole (Tiberal La Roche) was used in 50 persons infected with Giardia intestinalis in the dosis of 500 mg twice a day during 5 days. Examinations were performated after 7-10 days, having been repeated one month and 3 months later. A positive results were achieved after one month in 46 cases (92%) and after 3 months in 45 cases (90%). Tiberal is thought to be effective drug in the treatment of Giardiosis, causing no side effect apart from headache and nausea occurring sporadically
Author Correction: A dense ring of the trans-Neptunian object Quaoar outside its Roche limit.
No full textInternational audienc
Mate, You’re Crippin’ Us Out
No full textThe article explores arts curriculum in Australia as developed in the contexts of schooling, community organizations, and higher education f or people with disabilities and mental health concerns. Motivated to e xplore whether or not students provided access to modified arts curric ulum are engaging in education or receiving therapy, the aim is to add ress a dichotomy that is seemingly present in educational institutions , but extends well beyond the school gate and informs organizational r esponses to arts in the lives of people with disabilities. Resourced w ith the theoretical contributions of dis/ability studies for its conce rn for the biopolitics of disability, the authors weave personal exper iences through the discussion of participation in arts throughout thei r lives. The article concludes with a theoretical discussion of how ar ts provision in the Australian context might develop the social and po litical value of art in the lives of people with dis/abilities and for all, on the basis that its educative value is emphasized over its the rapeutic one
PIPASupplementaryTable1 – Supplemental material for Trends in Primary Proximal Interphalangeal Joint System and Revisions for Osteoarthritis of the Hand in the Medicare Database
No full textSupplemental material, PIPASupplementaryTable1 for Trends in Primary Proximal Interphalangeal Joint System and Revisions for Osteoarthritis of the Hand in the Medicare Database by Michael O. Madden, Joseph R. Palmer, Bijan J. Ameri, Rushabh M. Vakharia, Jacob Landes and Martin W. Roche in HAND</p
A dense ring of the trans-Neptunian object Quaoar outside its Roche limit
No full textMorgado, B. E. et al.--Full list of authors: Morgado, B. E.; Sicardy, B.; Braga-Ribas, F.; Ortiz, J. L.; Salo, H.; Vachier, F.; Desmars, J.; Pereira, C. L.; Santos-Sanz, P.; Sfair, R.; de Santana, T.; Assafin, M.; Vieira-Martins, R.; Gomes-Junior, A. R.; Margoti, G.; Dhillon, V. S.; Fernandez-Valenzuela, E.; Broughton, J.; Bradshaw, J.; Langersek, R.; Benedetti-Rossi, G.; Souami, D.; Holler, B. J.; Kretlow, M.; Boufleur, R. C.; Camargo, J. I. B.; Duffard, R.; Beisker, W.; Morales, N.; Lecacheux, J.; Rommel, F. L.; Herald, D.; Benz, W.; Jehin, E.; Jankowsky, F.; Marsh, T. R.; Littlefair, S. P.; Bruno, G.; Pagano, I.; Brandeker, A.; Collier-Cameron, A.; Floren, H. G.; Hara, N.; Olofsson, G.; Wilson, T. G.; Benkhaldoun, Z.; Busuttil, R.; Burdanov, A.; Ferrais, M.; Gault, D.; Gillon, M.; Hanna, W.; Kerr, S.; Kolb, U.; Nosworthy, P.; Sebastian, D.; Snodgrass, C.; Teng, J. P.; de Wit, J.Planetary rings are observed not only around giant planets1, but also around small bodies such as the Centaur Chariklo2 and the dwarf planet Haumea3. Up to now, all known dense rings were located close enough to their parent bodies, being inside the Roche limit, where tidal forces prevent material with reasonable densities from aggregating into a satellite. Here we report observations of an inhomogeneous ring around the trans-Neptunian body (50000) Quaoar. This trans-Neptunian object has an estimated radius4 of 555 km and possesses a roughly 80-km satellite5 (Weywot) that orbits at 24 Quaoar radii6,7. The detected ring orbits at 7.4 radii from the central body, which is well outside Quaoar’s classical Roche limit, thus indicating that this limit does not always determine where ring material can survive. Our local collisional simulations show that elastic collisions, based on laboratory experiments8, can maintain a ring far away from the body. Moreover, Quaoar’s ring orbits close to the 1/3 spin–orbit resonance9 with Quaoar, a property shared by Chariklo’s2,10,11 and Haumea’s3 rings, suggesting that this resonance plays a key role in ring confinement for small bodies. © 2023, The Author(s), under exclusive licence to Springer Nature Limited.This work was carried out under the Lucky Star umbrella that agglomerates the efforts of the Paris, Granada and Rio teams, which is funded by the ERC under the European Community’s H2020 (ERC grant agreement no. 669416). Part of the results were obtained using CHEOPS data. CHEOPS is an ESA mission in partnership with Switzerland with important contributions to the payload and the ground segment from Austria, Belgium, France, Germany, Hungary, Italy, Portugal, Spain, Sweden and the UK. The CHEOPS Consortium gratefully acknowledge the support received by all the agencies, offices, universities and industries involved. Their flexibility and willingness to explore new approaches were essential to the success of this mission. The design and construction of HiPERCAM was supported by the ERC under the European Union’s Seventh Framework Programme (FP/2007-2013) under ERC-2013-ADG grant agreement no. 340040 (HiPERCAM). HiPERCAM operations and V.S.D. are funded by the Science and Technology Facilities Council (grant no. ST/V000853/1). The GTC is installed at the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias, on the island of La Palma. This work has made use of data from the ESA mission Gaia (https://www.cosmos.esa.int/gaia), processed by the Gaia Data Processing and Analysis Consortium (DPAC, https://www.cosmos.esa.int/web/gaia/dpac/consortium). This study was financed in part by the National Institute of Science and Technology of the e-Universe project (INCT do e-Universo, CNPq grant no. 465376/2014-2). This study was financed in part by CAPES - Finance Code 001. The following authors acknowledge the respective (1) CNPq grants to B.E.M. no. 150612/2020-6; F.B.-R. no. 314772/2020-0; R.V.-M. no. 307368/2021-1; M.A. nos. 427700/2018-3, 310683/2017-3 and 473002/2013-2; and J.I.B.C. nos. 308150/2016-3 and 305917/2019-6. (2) CAPES/Cofecub grant to B.E.M. no. 394/2016-05. (3) FAPERJ grant no. M.A. E-26/111.488/2013. (4) FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo) grants to A.R.G.-J. no. 2018/11239-8 and R.S. no. 2016/24561-0. (5) CAPES-PrInt Program grant to G.B.-R. no. 88887.310463/2018-00, mobility number 88887.571156/2020-00. (6) DFG (the German Research Foundation) grant to R.S. no. 446102036. P.S-S. and R.D. acknowledge financial support by the Spanish grant no. AYA-RTI2018-098657-J-I00 ‘LEO-SBNAF’ (MCIU/AEI/FEDER, UE). J.L.O., P.S-S., R.D. and N.M. acknowledge financial support from the State Agency for Research of the Spanish MCIU through the ‘Center of Excellence Severo Ochoa’ award for the Instituto de Astrofísica de Andalucía (grant no. SEV-2017-0709), and they also acknowledge the financial support by the Spanish grant nos. AYA-2017-84637-R and PID2020-112789GB-I00, and the Proyectos de Excelencia de la Junta de Andalucía grant nos. 2012-FQM1776 and PY20-01309. G.B-R. and I.P. acknowledge support from CHEOPS ASI-INAF agreement no. 2019-29-HH.0. A.B. was supported by the SNSA. A.C.-C. and T.G.W. acknowledge support from STFC consolidated grant nos. ST/R000824/1 and ST/V000861/1, and UK Space Agency grant no. ST/R003203/1. U.K. and R.B. acknowledge support by The OpenSTEM Laboratories, an initiative funded by the Higher Education Funding Council for England and the Wolfson Foundation. J.W. gratefully acknowledges financial support from the Heising-Simons Foundation, C. Masson and P. A. Gilman for Artemis, the first telescope of the SPECULOOS network situated in Tenerife, Spain. The ULiege’s contribution to SPECULOOS has received funding from the ERC under the European Union’s Seventh Framework Programme (FP/2007-2013) (grant agreement no. 336480/SPECULOOS), from the Balzan Prize and Francqui Foundations, from the Belgian Scientific Research Foundation (F.R.S.-FNRS; grant no. T.0109.20), from the University of Liege and from the ARC grant for Concerted Research Actions financed by the Wallonia-Brussels Federation. TRAPPIST is a project funded by the Belgian Fonds (National) de la Recherche Scientique (F.R.S.-FNRS) under grant no. PDR T.0120.21. TRAPPIST-North is a project funded by the University of Liege, in collaboration with the Cadi Ayyad University of Marrakech (Morocco). E.J. is FNRS Senior Research Associate.With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (SEV-2017-0709).Peer reviewe
Markers of eosinophilic inflammation and tissue re-modelling in children before clinically diagnosed bronchial asthma
No full textChronic inflammatory changes in the bronchial mucosa have been well documented in patients with established asthma. Much less is known of the changes, which occur in the airways of children early in the evolution of their disease with most of the information based on indirect markers of inflammation only. We evaluated markers of inflammation and tissue re-modelling in bronchial biopsies from children with early respiratory symptoms before a clear clinical diagnosis of bronchial asthma could be made. We examined bronchial biopsies performed in 27 children between the ages of 1.2 and 11.7 yr who were bronchoscoped for a clinical indication because of recurrent or chronic respiratory symptoms. The patients were re-evaluated 22–80 months after the original bronchoscopy to determine whether or not they had subsequently developed bronchial asthma. There were more eosinophils in the bronchial mucosa (129.4 vs. 19.1 cells/mm² of lamina propria, p < 0.001) and the thickness of the subepithelial lamina reticularis was greater (4.65 vs. 3.72 ?m, p = 0.044) in children with bronchial asthma diagnosed at follow-up, compared with the children who did not progress to asthma. Eosinophilic inflammation and airway re-modelling occur early in the natural history of bronchial asthma and are present even before asthma would be diagnosed based on clinical symptoms. Recognition of these changes and their significance for clinical disease should emphasize the need for timely detection and diagnosis of asthma in children to facilitate the early introduction of anti-asthma therapy
Asthma deaths; persistent and preventable mortality
No full textBronchial asthma remains a significant cause of mortality at all ages, despite the increased understanding of its pathogenesis and the range of drugs available for its treatment. Changes in therapeutic management can influence death rates and constant surveillance, combined with high-quality post mortem investigations, is essential. Disease severity, poor disease management and adverse psychosocial circumstances are all risk factors for asthma mortality. Bronchial asthma causes characteristic histological changes in the mucosa of the airways which are present even before the clinical diagnosis of asthma can be made. These include fibrous thickening of the lamina reticularis of the epithelial basement membrane, smooth muscle hypertrophy and hyperplasia, increased mucosal vascularity and an eosinophil-rich inflammatory cell infiltrate. In addition, mucoid plugging of the airway lumen is frequently associated with fatal asthma. The recognition of these changes can allow the diagnosis of asthma to be made for the first time at autopsy, in those cases where asthma goes undiagnosed in life. Acute severe asthma may be accompanied by pneumothorax and surgical emphysema of the mediastinum. Disorders which may mimic asthma include pulmonary embolism, chronic obstructive pulmonary disease and anaphylaxis, but careful post mortem examination and appropriate investigations should reveal the true cause of death
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