1,720,973 research outputs found
PREDICTORS OF CARDIOVASCULAR RISK IN PATIENTS WITH RHEUMATOID ARTHRITIS: CORRELATION BETWEEN THE PRESENCE OF CARDIOVASCULAR DISEASE AND CHARACTERISTICS OF THE JOINT DISEASE
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PREDICTORS OF CARDIOVASCULAR RISK IN PATIENTS WITH RHEUMATOID ARTHRITIS
CORRELATION BETWEEN THE PRESENCE OF CARDIOVASCULAR DISEASE AND CHARACTERISTICS OF THE JOINT DISEASE
Borghi, C.; Bentivenga, C.; Cicero, A.F.; Trevisani, M.; Rossi, E.; Viviani, F.; Maranini, B.; Mulè, R.; Vukatana, G.; Buffa, A.; Corvaglia, S.; Malavolta, N.
Author Information
Journal of Hypertension 37():p e225-e226, July 2019. | DOI: 10.1097/01.hjh.0000572904.86052.da
Abstract
Objective:
Cardiovascular events represent the leading cause of death in patients with rheumatoid arthritis. Traditional cardiovascular risk factors alone do not adequately explain the phenomenon. This is probably due to other risk factors typical of joint disease, such as chronic inflammation and autoantibodies. Our study investigated the traditional cardiovascular risk factors and the characteristics of joint disease in a population of 374 patients with rheumatoid arthritis, in order to identify elements that allow a more adequate stratification and risk management.
Design and method:
A retrospective study was conducted that evaluated the traditional cardiovascular risk factors and characteristics of joint disease, ie disease duration, antibody profile and extra-articular manifestations. In addition, the therapy taken by patients for the treatment of rheumatoid arthritis was investigated and QRISK2 was calculated.
Results:
RF (Rheumatoid Factor) positive and ACPA (anti-citrullinated peptide antibodies) positive subjects have higher QRISK2 values than subjects who have either negative antibodies or either one positive (p = 0.038). Among patients with QRISK2 > 20% (high cardiovascular risk) 60% had RF and ACPA positive (p = 0.02). The correlations between antibody positivity (FR and ACPA), QRISK2 values and cardiovascular event were also compared; it was observed that statistically significant p values are obtained (p = 0.003).
Conclusions:
In our patient cohort, subjects at high cardiovascular risk, calculated on the basis of QRISK2, are predominantly FR and ACPA positive subjects. The addition of the autoantibody evaluation to QRISK2 increases the predictability of cardiovascular risk assessment in this patient population. We can suggest how further studies can support these hypotheses and we can support the evaluation of autoantibodies, easy to perform in the clinical setting, to the scoring systems currently used, to better outline the cardiovascular risk in patients suffering from rheumatoid arthritis, in order to implement also adequate prevention of cardiovascular events
Efficacia della terapia sistemica con Idrossiclorochina solfato (Plaquenil) sulla superficie oculare di pazienti affetti da Sindrome di Sjogren's primaria
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Alopecia universalis after discontinuation of pegylated interferon and ribavirin combination therapy for hepatitis C: a case report.
Full text linkFor the last decade, the combination therapy of pegylated interferon (Peg-IFN) plus ribavirin (RBV) has been considered as the standard of care treatment for chronic hepatitis C virus (HCV) infection. However, it has been associated with an increased incidence of many adverse cutaneous reactions and emergence of autoantibodies or even autoimmune diseases. We report a case of irreversible alopecia universalis (AU) with complete hair loss extended to the whole body, which started after discontinuation of Peg-IFN/RBV combination therapy for chronic HCV infection. In conclusion, this case represents an uncommon presentation of a common disease. Physicians must be aware of the potential adverse reactions of an antiviral therapy containing IFN, which might occur even after the discontinuation, and fully inform the patient at the beginning of his treatment course. We hope that interferon-free regimens will utterly supplant interferon-based therapy for most or all HCV patients avoiding the emergence of autoimmune manifestations
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
PREDICTIVITY OF OCULAR SURFACE PARAMETERS AND TEAR PROTEIN EXPRESSION IN THE DIAGNOSIS OF SJOGREN SYNDROME VERSUS DRY EYE
No full textANALISI DI PROTEINE SALIVARI IN PAZIENTI AFFETTI DA SINDROME DI SJOGREN’S: POSSIBILE UTILE ALTERNATIVA NELLA VALUTAZIONE FUNZIONALE DI GHIANDOLE SALIVARI ?
No full textDispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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