2,286 research outputs found
Regulation of the blood-brain barrier in health and disease: Astrocytes at the barricade
No full textVries, H.E. de [Promotor]Dijkstra, C.D. [Promotor]Reijerkerk, A. [Copromotor
Phylogenomic insights into the first multicellular streptophyte
No full text100010661 Horizon 2020 Framework Programme100010663 European Research Council501100000781 European Research Council501100001659 Deutsche Forschungsgemeinschaf
Verslag van het voorgevallene tijdens het hooge opperwater op de Nederlandsche rivieren in den winter van 1919 op 1920
No full textNadat de Rijn op 20 December 1919 tot even beneden den middelbaren zomerstand 1901-1910 (M.R.) was gedaald vertoonde zich op die rivier een sterke en vrij snelle was, waardoor het water te Keulen tot 6m +M.R. bij het einde van het jaar steeg. In de daarop volgende 11 dagen daalde de waterstand tot 1.5m +M.R. om daarna in 5 dagen weder te rijzen tot den zeer hoogen stand van 7m +M.R. Door een aanvankelijk sterken later flauweren val liep de stand weder terug tot 1.5m +M.R. op 30 Januari. Ook op de Maas vertoonden zich twee dicht op elkaar volgende sterke wassen. Bij den aanvang van den eersten was op 19 december stond het water te Maastricht op ruim 1m +M.R. en steeg het in 6 dagen tot 4.37m +M.R.; in de daaropvolgende 9 dagen bleef de stand steeds hoger dan 4m +M.R. en daalde toen tot ongeveer 2m +M.R. op 10 Januari 1920. De tweede was trad op laatsgenoemde datum in waarbij het water oplied tot 4.94m +M.R. op 15 Januari. Het water daalde daarna dadelijk en was op 29 Januari tot ongeveer 2m +M.R. weggevallen. Bij den tweeden was op Rijn en Maas werden de hoogst bekende waterstanden bij open rivieren overtroffen te Keulen met 7 cm en te Maastricht met 2 cm. De rivieren waren ijsvrij.Hoogwaterversla
Triple-layer membrane structures: Sound insulation performance and practical solutions
No full textThis report describes a Master’s Thesis research that has been carried out to gain insight in the possible improvements of sound insulation of membrane structures, which are used in practice for temporary structures, e.g. festival tents, and to give practical solutions. This research concentrated on triple-leaf membrane systems with filled cavities. From a state-of-the-art review can be concluded that triple-leaf membrane systems, when filled, perform better than double-leaf and single-leaf membrane structures. From literature research it was concluded as well that tension in the membrane has a negligible effect on the sound insulation and that, on the other hand the flow resistance both of the filling and of the membrane material has large influence. Three different kind of filling materials were used in the present study: (lightweight) glass wool, polyester wool and aerogel. Acoustical measurements were carried out in a laboratory, of which the outcomes were compared to a number of computer and mathematical models. The Multiple Layer Model appears to give good prediction for filled triple-layer membrane systems and this model therefore was used to optimise the important parameters. A well performing triple-layer membrane system was discussed, which met the restriction of 7kg/m2 for the surface density of the membrane package. This system includes one layer of aerogel for reasonable sound insulation at low frequencies, and one thicker layer of glass wool yielding good sound insulation at higher frequencies. This system is only investigated theoretically for nog and not empirically (yet). Details have been worked out for a number of practical membrane structure applications for this result (also applicable to variants using only glass wool), focussing on temporary (festival) tent structures.Building PhysicsBuilding EngineeringCivil Engineering and Geoscience
The Existence of Pure-Strategy Nash Equilibrium in Games with Payoffs that are Not Quasiconcave
No full textPilot validation of the Tuberous Sclerosis Associated Neuropsychiatric Disorders (TAND) checklist as a screening tool for neuropsychiatric manifestations
No full textIncludes abstract.
Includes bibliographical references
Cervical dystonia : abnormal cerebral activation patterns related to preparation and execution of hand movement
No full textCervical dystonia (CD) is a movement disorder characterized by sustained involuntary muscular contractions which cause repetitive twisting movements and abnormal postures of the head. CD is primarily a brain disorder. Several studies show that CD patients have abnormal brain activity not only during movement execution but also movement preparation. An important area for movement preparation is the parietal cortex where sensory information is integrated in the movement preparation plan. In CD, this parietal cortex seems to function abnormally since extra sensory information (by touching the chin or cheek) can temporarily reduce dystonia. This thesis investigated execution and preparation of movement in CD and healthy controls by letting the subjects perform and imagine a flexion/ extension movement in a normal, non-dystonic hand. Imagination of movement activates specific brain areas which are related to preparation of movement. Both tasks showed lower parietal cortex activity in CD compared to healthy controls. Induced impairment of the parietal cortex by transcranial magnetic stimulation (TMS) in healthy controls showed specific brain activation changes that were similar to brain activation patterns in CD patients without TMS. Parietal cortex TMS in CD reduced the already low activity even further and increased activity in other brain regions. These results confirm that the parietal cortex is impaired in CD. This functional impairment seems to be compensated by other brain regions during movement in normal, non-dystonic body parts. However, the electromyography study in this thesis showed that full compensation is not reached, although visually the movement looked normal. Execution of a flexion/ extension movement of a normal, non-dystonic hand in CD patients demonstrated lower muscle strength during wrist flexion and longer muscle activation during wrist extension. Nevertheless, in CD other factors besides impaired compensation mechanisms may be in play to undermine the neck movements in CD patients in such a way that it becomes dystonic.
: A software platform for centralizing, enriching and spatializing heterogeneous data
No full textContributeurs : Violette Abergel, Marco Callieri, Isabelle Cao, Livio De Luca, Anaïs Guillem, Olivier Malavergne, Adeline Manuel, Ariane Néroulidis, Thomas Pouyet, Roxane Roussel, Miled Rousset, Sarah Tournon, Aurore Pfitzmann //Author contributions : Conceptualization: L.D.L.; Data curation: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Formal analysis: ; Funding acquisition: L.D.L.; Investigation: ; Methodology: ; Project administration: L.D.L., A.P.; Resources: ; Software: ; Supervision: L.D.L.; Validation: L.D.L.; Visualization: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Writing – original draft: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Writing – review & editing: L.D.L.International audiencePresentation of the tools making up the n-Dame ecosystem designed by members of the “Digital Data” Working Group of the Chantier Scientifique Notre-Dame.Présentation des outils composant l'écosystème n-Dame conçu par les membres du Groupe de Travail "Données numériques" du Chantier Scientifique Notre-Dame
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