3,735 research outputs found
Designing a LEGO-based microscope for an educational setting
No full textHere we present the design of a high-resolution, high-magnification micro- scope using LEGO® bricks and easily-available lenses. With the provided workflow and suggested experiments, we show that 9-to-13-year old students significantly increased their understanding of microscopy
Combining light sheet microscopy and optical tweezers for simultaneous micromanipulation and 3D visualization
No full textTo investigate the relation between structural and local mechanical properties in biological tissues, we develop a light sheet microscope combined with optical tweezers for in vivo imaging and microrheology
Archives Reenergized: Using a Milestone Anniversary to Reinvigorate Interest in Your Collections
No full textThe Peirce College Library used the College's sesquicentennial anniversary to showcase its archive collection internally and externally,"July/August, 2015
Interactions between STAT3 and BART
Get PDFSignal transducers and activators of transcription (STATs) mediate cell proliferation, differentiation, and survival in immune responses, hematopoiesis, neurogenesis, and other biological processes. STAT3, for example, is involved in the epithelialmesenchymal transition during gastrulation, organogenesis, wound healing, and cancer progression. STAT activity is regulated by a variety of mechanisms, including nuclear translocation. To clarify the molecular mechanisms underlying the regulation of STAT activity, we performed yeast two-hybrid screening. Here we identified BART (Binder of ADP-ribosylation factor-like Two) as a novel STAT-binding partner. Importantly, we showed that BART is essential for the transcriptional activity and nuclear retention of STAT3. Furthermore, an effector of BART, ADP-ribosylation factor-like 2 (ARL2) was also involved in nuclear retention of STAT3. These results indicate that BART plays an essential role in the nuclear retention of STAT3 through interaction with ARL2
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