1,721,065 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Anoctamin-5-Myopathie : Klinik, Histologie und Proteom einer Hallenser Kohorte
Get PDFDie Anoctamin-5-Myopathie ist eine der häufigsten Ursachen für hereditäre Myopathien in Nordeuropa. Klinisch und histologisch zeigt die Erkrankung ein äußerst heterogenes Bild. Ursächlich sind rezessive Mutationen im Anoctamin-5-Gen. Zwölf Patienten mit genetisch nachgewiesener Anoctamin-5-Myopathie der neurologischen Universitätsklinik Halle/Saale wurden klinisch charakterisiert und die Muskelbiopsien wurden histologisch untersucht. Darüber hinaus erfolgte eine Proteomanalyse. Klinisch und histologisch konnte bei den Hallenser Patienten typische Veränderungen der Anoctamin-5-Myopathie nachgewiesen werden. Die Proteomanalyse ergab eine Fehlregulation verschiedener Proteingruppen. Zusammenfassend ergab sich in der Hallenser Kohorte keine Beziehung zwischen einem bestimmten klinischen oder histologischen Phänotyp und einem bestimmten Genotyp. Die klinische Heterogenität der Erkrankung spiegelte sich auch auf der Proteomebene wider.Anoctamine 5 myopathy is one of the most common causes of hereditary myopathies in Northern Europe. Clinically and histologically, the disease shows an extremely heterogeneous appearance. The cause is recessive mutations in the anoctamine-5 gene. Twelve patients with genetically proven anoctamine-5-myopathy from the neurological university hospital Halle/Saale were characterized clinically and the muscle biopsies were examined histologically. In addition, a proteomic analysis was performed. Clinically and histologically, typical changes of anoctamine-5-myopathy could be detected in the Halle patients. Proteomic analysis revealed dysregulation of several protein groups. In summary, no correlation between a specific clinical or histological phenotype and a specific genotype was found in the Halle cohort. The clinical heterogeneity of the disease was also reflected at the proteome level.Druckfehler auf der Titelseite beim Verteidigungsdatum: 15.05.2023, korrekt ist 15.08.202
Der Einfluss von Cardiolipin auf die Aktivität des Wildtyps und der Mutante S113L der Carnitin-Palmitoyl-Transferase II
Get PDFDie Phospholipidumgebung der inneren Mitochondrienmembran, welche Cardiolipin in großen Anteilen enthält, könnte eine entscheidende Rolle im Transport langkettiger Fettsäuren spielen. In der vorliegenden Arbeit konnte eine mehr als 1.5-fache Steigerung der Aktivität des Wildtyp-Enzyms der Carnitin-Palmitoyl-Transferase (CPT) II durch Präinkubation mit Cardiolipin bei physiologischen Temperaturen erreicht werden. Bei höheren Temperaturen zeigte sich jedoch ein starker Aktivitätsverlust. Für die am häufigsten vorkommende Mutante des CPT-II-Enzyms konnte bereits bei 37 °C unter Zugabe von Cardiolipin ein ausgeprägter Aktivitätsverlust verzeichnet werden. In der simulierten Fiebersituation war dieser Effekt verglichen mit dem Wildtyp stärker ausgeprägt. Der Grund hierfür könnte eine gestörte Membraninteraktion oder eine Blockade es aktiven Zentrums sein des mutierten Enzyms sein.The phospholipid environment of the mitochondrial inner membrane, which contains large amounts of cardiolipin, could play a key role in transport of the long chain fatty acids. In the present study, the preincubation of cardiolipin with the wild type carnitine palmitoyltransferase (CPT) II led to a more than 1.5-fold increase of enzyme activity at physiological temperatures. At higher temperatures, however, there was a pronounced loss of activity. The most frequent variant S113L showed even at 37 °C a great activity loss. The activity loss in presence of cardiolipin at fever simulating situations was more pronounced for the variant comparing to the wild type. The reason might be a disturbed membrane association or a blockage of the active center of the mutated enzyme
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Die okulopharyngeale Muskeldystrophie in Deutschland - eine genotypische und phänotypische Analyse
Get PDFDie okulopharyngeale Muskeldystrophie (OPMD) ist eine autosomal dominante Myopathie, welche durch einen späten Krankheitsbeginn und die Kardinalsymptome Ptosis, Dysphagie und im Spätstadium auftretende proximale Paraparesen gekennzeichnet ist. Um die OPMD in Deutschland zu charakterisieren, analysierten wir 195 OPMD Patienten. Das Erkrankungsalter in unserer Kohorte lag bei 54,1 Jahren. In der Mehrzahl der Fälle waren eine Ptosis bzw. eine simultan auftretende Ptosis und Dysphagie das Erstsymptom. Proximale Paraparesen traten im fortgeschrittenen Krankheitsstadium auf. Mit 14 dominanten und 2 rezessiven Genotypen handelt es sich hier um die bis dato heterogenste, beschriebene Kohorte. Wir fanden keinen Unterschied im Phänotyp zwischen Trägern reiner GCG-Expansionen und Trägern von Expansionen mit GCA-Einschüben. Es zeigte sich ein Trend zu einem früheren Krankheitsbeginn mit zunehmender Expansionslänge. Der frühe Krankheitsbeginn in einem Fall mit rezessiver OPMD könnte ein Hinweis auf weitere den Phänotyp beeinflussende Faktoren sein. Ein symptomatischer Fall eines heterozygoten Trägers der (GCG)1-Expansion suggeriert, dass diese Variante nicht wirklich rezessiv wirkt. Es konnten keine Hinweise auf das Vorliegen von Gründereffekten gefunden werden.Oculopharyngeal muscular dystrophy (OPMD) is a genetically inherited late onset disorder charaterized by progressive ptosis, dysphagia and weakness of the proximal limbs. The causative genetic defect is a triplet expansion in the poly(A) binding protein 1 (PABPN1) gene. In order to characterize the OPMD in the german population we analized 195 OPMD patients. In our cohort the mean age at onset was 54.1 years. Ptosis preceded or occured simultanously with dysphagia in the majority of cases. Proximal limb muscle weakness occured with disease progression. The spectrum of 16 genotypes (14 dominant and 2 recessive) makes this cohort the genetically most heterogeneous described to date. No difference in phenotype between pure GCG expansions and those with GCA interspersions could be found. We found a trend towards an earlier onset with a rising repeat length in the PABPN1 gene. One case of recessive OPMD with a severe phenotype and early disease onset suggests that other factors apart from the genotype could modify the phenotype. A case of a affected heterocygote for the (GCG)1 expansion suggests that the recessive allel acts possibly not truly recessive. There was no hint for a founder effect in our cohort.vorgelegt von Tomasz Banisc
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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