148 research outputs found
Bibliographics for the 983 eprints in the live archives of E-LIS : trends and status report up to 7th July 2004, based on author-self-archiving metadata
Get PDFThe priority for ideas and philosophy related to "Network Theory" have been traced back and documented by Braun(2004),and credit goes to Karinthy(1929).The IT has empowered to realise it, as the most practical phenomena and it is no more a humour. The OAI (Open Archives Initiatives)and ACIS (Academic Contributor Information System)are progressive in the direction ,which may lead to realise the "Collective Genius" at global level. Focus of present study is on Author-Self-Archiving (A-S-A)Metadata of the 983 Eprints in the Live Archives of the E-LIS (EPrints of Library and Information Science),which were approved till 7th July 2004.The A-S-A Metadata was used for librametric analysis. Self-explanatory bibliographics are illustrated.The highlights include: Conference papers (34%); highest approval, June 2004 (28%); published archives (76%);not refereed (52%); not in public domain (60%); highest self-archiving-author (De Robbio, Antonella).The Nos. of EPrints having single JITA domain specifications were: Theoretical and general aspects of libraries and information(27); Information use and sociology of information(80);Users,literacy and reading(13);Libraries as physical collections(30);Publishing and legal issues(57);Management(13);Industry, profession and education(36);Information sources, supports, channels(113) ; Information treatment for information services, Information functions and techniques (101); Technical services libraries, archives and museums(25); Housing technologies(1); Information technology and library technology(92); and Inter-domainery (395) i.e. having specifications of two or more than two JITA classes
INSPEC database analysis for Knowledge Management records
No full textThe study deals with the Knowledge Management papers covered in the INSPEC, an international database on Information Science, Physical Sciences, Engineering and Computer Sciences. The papers have been analysed in terms of their content and other scientometric parameters
Abstract 36: Changes in cellular and molecular immune markers in the peripheral blood of patients undergoing chemotherapy and radiation for squamous cell carcinoma of head and neck: A prospective pilot study
No full textAbstract
Objective: In order to help further development of novel immunotherapeutic targets related to signal-transducer and activator of transcription-3 (STAT3) in squamous cell carcinoma of head and neck (SCCHN), data are needed to help understand changes in immune-mediated signaling during treatment. The purpose of this study was to analyze changes in the mRNA or protein expression of inflammatory or immunosuppressive mediators in peripheral blood mononuclear cells (PBMC) or plasma, in SCCHN patients receiving concurrent chemotherapy and radiation therapy (CRT).
Methods: This was a prospective biospecimen collection study of 15 patients with stage III-IV SCCHN who received CRT with curative intent. Blood specimens were obtained before, during weeks 1, 2, 4, 6, and 7 of CRT, and 6-12 weeks after treatment completion. Plasma and PBMC were separated from patients' blood using Vacutainer CPT tubes (BD Bioscience) within 2 hours after collection by centrifugation at 1800×g for 20 min at room temperature and stored in -80°C. Plasma samples were analyzed for 30 human cytokines and chemokines using Luminex FLEXMAP 3D system at the Clinical Immunobiology Correlative Studies (CICSL) core at City of Hope. mRNA was isolated from PBMCs acquired at the baseline and at the second week draw during RT from 6 patients and expression of 730 genes selected for immune profiling was evaluated using nCounter Immune Cell Profiling Assay, and data were analyzed using nSolver software (Nanostring).
Results: Among the plasma level of 30 cytokines tested by Luminex Assay, IL-6 showed cumulative increase during RT (one-way ANOVA, p=0.046). At 6 week post RT, IL-6 level decreased comparable to baseline level. Plasma level of IFN-gamma was significantly increased at 2 week of RT and the level remained unchanged until 12 week post CRT (p=0.0004). In contrast, we observed pro-inflammatory cytokine IL-12 was significantly decreased during CRT (p=0.0004). Plasma level of a tumor promoting cytokine HGF was significantly increased during and 12 week post CRT (p=0.0035). Comparison of gene expression profiles in PBMC from 6 patients between baseline and the second week of CRT indicates that mRNA expression of 335 immune-regulators are differentially expressed (p<0.05) among 740 tested. Consistent with the plasma cytokine analysis, mRNA level of IL-6 in PBMC was 13.9 fold increased (p=0.003). Subsequently, increase in STAT3 expression was observed (1.7 fold, p=0.002) since IL-6 stimulates Janus kinase (JAK)-STAT pathway. In addition, mRNA expression of Th2 cytokines including IL-10, IL-5, and TGFb1 were significantly increased by greater than 2 folds (p<0.05).
Conclusion: These results suggest CRT affects immune activation in SCCHN patients systemically, which may contribute to immune suppression and disease relapse after treatment. Our data provide an impetus for investigating STAT3-targeted therapies in SCCHN.
Citation Format: Sagus Sampath, Hae Jung Won, Ellie Maghami, Erminia Massarelli, Nayana Vora, Lalit Vora, Marcin Kortylewski. Changes in cellular and molecular immune markers in the peripheral blood of patients undergoing chemotherapy and radiation for squamous cell carcinoma of head and neck: A prospective pilot study [abstract]. In: Proceedings of the AACR-AHNS Head and Neck Cancer Conference: Optimizing Survival and Quality of Life through Basic, Clinical, and Translational Research; April 23-25, 2017; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(23_Suppl):Abstract nr 36.</jats:p
The provenance and the paleo-environment of the Siwalik Group along the Muksar Khola section, eastern Nepal Himalaya (東ネパール，ムクサー川沿いに分布するシワリク層群の供給源と古環境)
Get PDF信州大学(Shinshu university)博士（理学）この博士論文は、次の学術雑誌論文を一部に使用しています。 / Journal of Nepal Geological Society 60 :207-224(2020); doi:10.3126/jngs.v60i0.31275 © Nepal Geological Society/ SEDIMENTARY GEOLOGY :105920(2021); doi:10.1016/j.sedgeo.2021.105920 © 2021 Elsevier B.V. All rights reserved./ PROGRESS IN EARTH AND PLANETARY SCIENCE 8(1) :49(2021); doi:10.1186/s40645-021-00444-5 © The Author(s). 2021ThesisRAI LALIT KUMAR. The provenance and the paleo-environment of the Siwalik Group along the Muksar Khola section, eastern Nepal Himalaya (東ネパール，ムクサー川沿いに分布するシワリク層群の供給源と古環境). 信州大学, 2022, 博士論文. 博士（理学）, 乙第19号, 令和04年03月20日授与.doctoral thesi
Analytical study of contents of LANL physics and cross-listed e-print archives, 1994-2002
No full textThe frontiers of physics and cross-listed e-print archives posted during the years 1994-2002 at http://www.arxiv.org/archives/physics web service of Los Alamos National Laboratory (LANL) are explored from 7770 submissions. E-print archives posted to top most six physics-cross-listed research categories besides physics (5390) are: Condensed matter (754), Quantum physics (279), Astrophysics (222), Chemical physics (129), High energy physics - Phenomenology (118), and High energy physics-Theory (100). Prominent contributors are B.G. Sidharth (India), V.V. Flambaum (Australia), Antonina N. Fedorova (Russia), and Michael G. Zeitlin (Russia). Most preferred journals for rechannelising e-print archives are Physical Review Letters, Physical Review A, Physical Review E, Nuclear Instruments and Methods A, and Journal of Chemical Physics
Scientometric portrait of Nobel laureate Leland H. Hartwell
Get PDFLeland H. Hartwell was honoured with the Nobel Prize in Physiology or Medicine (2001) at his 62 years age and at 41 years of research publishing career. The first contribution of the author was in 1961 at the age of 22. The number of his contributions in a year peaked in 1997 when it touched 8. He had 108 publications during 1961 – 2001 in domains: Molecular Biology of Cell Cycle Regulation (43), Genetics of Cell Division (48), Genomic Re-arrangement and DNA Repair (9), Molecular Genetics of Yeast Cell Fission (5), and Drug Target Interaction (3) which were analysed for authorship pattern with his 101 collaborators. Most active researchers having number of publications with Leland H. Hartwell were : Weinert, T. A. (10), Garvik, B. M. (8), McLaughlin, C. S. (8), Jenness, D. D. (5). His productivity coefficient was 0.76 which clearly indicates that his productivity increased after 50 percentile age. Highest collaboration coefficient (1) for Leland H. Hartwell was found during 1963-1965, 1968-1969, 1977, 1981-1983, 1985-1990, 1996 and 1998-2001. Journals have been the most preferred channel of communication where, as many as 96 papers out of 108 have been published. The core journals publishing his papers were: Cell (14), Genetics (12), Mol. Cell Biol. (8), J. Bactariol. (7), J. Cell Biol. ( 7), Science (7) J. Mol. Biol.(6), Exp. Cell Res. (5), and Proc. Nat. Acad. Sci.(5). Publication density is 2.63 and Publication concentration is 14.63. Most prolific keywords in titles of publications were: Saccharomyces cerevisiae , Yeast , Cell division cycle , RAD9, DNA Damage , Genes , Cell cycle, Genetic control , Check point (s) , Cell division , Mutant of Yeast
the use of gravimetric and chromatographic analysis to study the surface properties of powders
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
The use of gravimetric and chromatographic analysis to study surface properties of powders.
Get PDFPharmaceutical processing can affect the crystallinity of drug substances, leading to batch-to-batch variation and changes in the physicochemical behaviour of the final dosage form. The study of the effects of such processing is important to allow the control of manufacturing procedures in order to ensure the consistent quality of the finished product. The aims were to investigate and measure the changes in the surface properties of four compounds when subjected to pharmaceutical processing. The work also highlights the difficulties associated with the study of hydrates due to their water loss either by accident or intent when equilibrated prior to experimental analysis. Characterisation studies using a gravimetric approach coupled with near infrared spectroscopy showed the discovery of a new crystal transition for theophylline during hydration of the dehydrate lattice. A crystallisation type transition at 40-50% relative humidity occurred during rehydration. This suggested a probable "ghost hydrate structure" for the dehydrate packing. The sorption of water, during rehydration, allowed the structure to have sufficient mobility to transform back into the anhydrous form prior to hydrate formation. Such a technique can show real-time events of solid-state transitions for sophisticated powdered solids, and can thus help formulators monitor changes during manufacture of a product. Gravimetric analysis of compounds using a novel approach of probing the surface with solvents other than water provided useful data. It was possible to follow changes in non-micronised and micronised calcium mupirocin. Due to the hydrophilic nature of the compound it interacted with the polar probes to a greater extent. Once micronised the sample showed stronger wettability to all the probes probably due to amorphous regions, greater surface energy and/or larger surface areas created during micronisation. Interestingly, tests on the micronised sample after one year showed some recovery suggesting that increased surface area was not the only cause of the greater wetting but possibly also changes in the surface energy. Changes on the dihydrate form were not measurable due to the inability to retain the hydrate when water vapour was absent from the system. The method proved unsuitable for the other compounds due to minimal wetting or poor equilibration. This technique has allowed process-induced batch variability to be measured where conventional techniques such as x-ray diffractometry and solution calorimetry have failed. Chromatographic analysis of the surface of the compounds has proved successful especially where the gravimetric approach has shown limitations. Differences in surface energetics of both micronised and non-micronised forms of calcium mupirocin and nabumetone were attainable. Over time the surface energy of the samples recovered, suggesting the formation of a thermodynamically unstable surface state immediately after micronisation. Measurements of the hydrated forms (calcium mupirocin and theophylline) were possible chromatographically. Water into/onto the drugs reduced the dispersive and acidic components of the surface. Also the dehydrated form of theophylline showed very high surface energy values, corroborating the recognised instability of the lattice. Batch-to-batch variability between Sigma and Fluka forms of theophylline and magnesium stearate have also been highlighted by the differences in their respective surface energy values. Chromatography allows the determination of small changes in surface characteristics and has provided a new approach to successfully comparing hydrates for the first time. Gravimetric and chromatographic techniques have provided an alternative method to investigate process induced batch variability. Understanding the way surfaces interact with probes of varying polarity can help allow the selection of the appropriate solvent during processing in order to prevent undesirable changes to the original compound
Prospects for computer applications in law
No full textThe author in arguing for the need of the legal profession and administration of justice to keep pace with technological advances made in all other fields all over the world, looks at the scope for computer applications in the legal field. The author further suggests that there will be fewer cases of exploiting the law because there will be less chance of manipulating the opposing counsel, or the judge. (Editor’s abstract.
- …
