1,721,343 research outputs found
Metastatic renal cell carcinoma stage migration: implications for trial design and analysis
No full textEditorial comment on Prognostic value of capsular invasion for localized clear cell renal cell carcinoma
No full textPietro da Rimini. L'inverno della critica.
No full textIl volume non raccoglie l’intero scibile e le immagini che per qualche ragione sono connesse alla figura di Pietro da Rimini, ordinando il tutto in una struttura riconoscibile come una monografia storico artistica. Le pochissime notizie che si riferiscono a lui, il catalogo del tutto incerto nell’ambito delle attribuzioni e delle datazioni, non lo consentono.
La pretesa di raccontare quel che davvero potrebbe essere accaduto a questa inafferrabile figura, come tenderebbe a fare una monografia, corrisponderebbe a una particolarissima ingenuità epistemologica, poiché ogni fatto artistico che riguarda Pietro da Rimini mostra caratteri evidentemente mutevoli se viene posto sotto la luce cangiante di uno sguardo che voglia tener conto sia delle voci che lo hanno discusso nel passato critico novecentesco, che delle motivazioni che dovrebbero guidare una riflessione circa la funzione della odierna storia dell’arte.
L'ambizione di questo studio è invece quella di proporre un’immagine dialettica del pittore trecentesco e di consegnare gli strumenti con cui il lettore possa tracciare la propria immagine di Pietro, nel rispetto delle pochissime certezze che il passato ci ha consegnato e della pluralità delle voci che un’importante vicenda storiografica ha prodotto su di lui
Editorial comment on Effects of once-daily tadalafil on erectile function in men with erectyle disfunction and signs and symptoms of benign prostatic hyperplasia
No full text
Editorial comment on Observation should be considered as an alternative in the management of renal masses in older and comorbid patients
No full textThe role of active surveillance of small renal masses
No full textINTRODUCTION:
The use of modern abdominal imaging modalities have led in recent years to an increased incidental diagnosis of small renal masses (SRMs), especially in elderly patients. The natural history of SRMs has been historically poorly understood because most have been traditionally surgically removed soon after diagnosis. However, several studies of active surveillance (AS) of SRMs have been published in the last decade.
METHODS:
A review of English-language publications on AS of SRMs was performed from 1995 to 2015 using the Medline, Embase and Web of Science databases. Fifty-six articles were selected based on their scientific relevance and critically analysed.
RESULTS:
When followed conservatively with serial imaging, SRMs have variable growth rates with an average of 0.31 cm/year in the largest multicenter analysis. A significant number of SRMs have a slow growth and some have zero growth under surveillance. The risk of progression to metastatic disease during AS is rare (1-2%). Population-based analyses in older patient populations (>75 years) fail to show a benefit in cancer-specific mortality for surgical treatment of SRMs.
DISCUSSION:
The standard of care for localized renal tumors is surgery. In elderly or unfit patients with decreased life expectancy, it is reasonable to propose an initial period of AS, with delayed intervention for those tumors which exhibit a fast growth during follow-up. At present AS is not recommended in younger and fit patients and for masses >4 cm at diagnosis outside clinical trials. Percutaneous needle biopsies of renal tumors have the potential to characterize histologically SRMs at diagnosis, thereby providing useful information for the selection of the best suited patients for AS.
CONCLUSIONS:
Most SRMs are benign tumors or RCCs with a relatively indolent clinical behaviour. AS can be offered to patients with SRMs and decreased life expectancy. Prospective series of AS of histologically confirmed RCCs are needed to confirm the long term safety of this conservative approach
Esthetic and historiographical condition of Giotto’s architectural frames
Full text linkContemporary esthetic discourse on Giotto’s architectural frames shall confront with historiography and philosophy of history. The artist’s Duecento motivations can be considered as antithetical to the consequences produced by Giotto techniques in the following century. Boccaccio’s observations on Giotto’s illusionism, which were followed by Longhi’s thought, are here considered to be in contrast to the postmodern gaze resting on the same pictorial objects
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