2,746 research outputs found
Della Volpe, Colletti e le scienze empiriche
No full textL'articolo discute le tesi filosofiche di Galvano Della Volpe e Lucio Colletti relative alle scienze empiriche e sostiene che mentre in Della Volpe la scienza affonda le sue radici nell'empirismo humiano, in Colletti prevale il punto di vista trascendentale kantiano
Rafael Argullol e il fascino dell'Italia
No full textIl saggio propone una lettura di Lampedusa. Una historia mediterránea, romanzo d’esordio di Rafael Argullol, finalizzata a mettere in luce la forte presenza dell’elemento mitico che permea l’intero testo, ma anche a ricostruire l’immagine complessa e contraddittoria dell’Italia che il testo riflette e ci restituisce
Napoli, Roma, Milano, Venezia: le tappe geopolitiche di un'Italia pre-unitaria nel romanzo "El puente de los asesinos" di Arturo Pérez Reverte
No full textsj-xlsx-1-ejo-10.1177_11206721211048803 – Supplemental material for Should we care about the ocular surface in the anophthalmic patient?
No full textSupplemental material, sj-xlsx-1-ejo-10.1177_11206721211048803 for Should we care about the ocular surface in the anophthalmic patient? by Giulio Volpe, Maria De Piano, Giacomilde Mazzone, Alessandra Micera, Stefano Bonini and Alessandra Claudia Modugno in European Journal of Ophthalmology</p
Targeting of calsequestrin to the sarcoplasmic reticulum of skeletal muscle following deletion of its carboxy-terminal acidic tail
No full textCalsequestrin (CS) is the Ca(2+) binding protein of the junctional sarcoplasmic reticulum (jSR) lumen. Recently, a chimeric CS-HA1, obtained by adding the nine-amino-acid viral epitope hemagglutinin (HA1) to the COOH terminus of CS, was shown to be correctly segregated to the sarcoplasmic reticulum [A. Nori, K. A. Nadalini, A. Martini, R. Rizzuto, A. Villa, and P. Volpe. Am. J. Physiol. 272 (Cell Physiol. 41): C1420-C1428, 1997]. A putative targeting mechanism of CS to jSR implies electrostatic interactions between negative charges on CS and positive charges on intraluminal domains of jSR integral proteins, such as triadin and junctin. To test this hypothesis, 2 deletion mutants of chimeric CS were engineered: CS-HA1DeltaGlu-Asp, in which the 14 acidic residues [-Glu-(Asp)(5)-Glu-(Asp)(7)-] of the COOH-terminal tail were removed, and CS-HA1Delta49(COOH), in which the last, mostly acidic, 49 residues of the COOH terminus were removed. Both mutant cDNAs were transiently transfected in HeLa cells, myoblasts of rat skeletal muscle primary cultures, or regenerating soleus muscle fibers of adult rats. The expression and intracellular localization of CS-HA1 mutants were studied by epifluorescence microscopy with use of antibodies against CS or HA1. CS-HA1 mutants were shown to be expressed, sorted, and correctly segregated to jSR. Thus short or long deletions of the COOH-terminal acidic tail do not influence the targeting mechanism of C
Sostenibilidad e inclusión: la diversidad como valor corporativo
No full textLa valorización de la diversidad y la inclusión representan elementos
fundamentales de la sostenibilidad corporativa, convirtiéndose en un
imperativo para las empresas que quieren crear valor competitivo. El esfuerzo
de las organizaciones empresariales debe estar orientado a crear
ambientes de trabajo inclusivos y adoptar estrategias para valorizar los
recursos corporativos en términos de diversidad, con el fin de promover
mejores condiciones organizacionales y obtener ventajas en términos de
producción y competitividad en el mercado. Nuestra investigación propone
una reflexión sobre el necesario cambio en las prácticas y políticas
de la empresa, gracias a un entorno de trabajo multicultural, inclusivo y
saludable, para también su impacto sobre el ambiente externo. En particular,
se presta atención a la comunicación con el consumidor, encaminada a incrementar la confianza, la fidelidad y el voz a voz positivo hacia la empresa. A tal fin, se reportan algunas buenas prácticas de comunicación
referidas a casos de negocios que transmiten bien su compromiso concreto
con el desarrollo de un sistema económico-social en el que nadie
esté excluido y en el que todos estén capacitados para expresar su propio
potencial y diversidad
Targeting of calsequestrin to the sarcoplasmic reticulum following deletions of its acidic carboxy terminus
No full textCalsequestrin (CS) is the Ca21 binding protein of the junctional sarcoplasmic reticulum (jSR) lumen. Recently, a chimeric CS-HA1, obtained by adding the nineamino-
acid viral epitope hemagglutinin (HA1) to the COOH terminus of CS, was shown to be correctly segregated to the sarcoplasmic reticulum [A. Nori, K. A. Nadalini, A. Martini,
R. Rizzuto, A. Villa, and P. Volpe. Am. J. Physiol. 272 (Cell
Physiol. 41): C1420–C1428, 1997].A putative targeting mechanism of CS to jSR implies electrostatic interactions between negative charges on CS and positive charges on intraluminal domains of jSR integral proteins, such as triadin and junctin. To test this hypothesis, 2 deletion mutants of chimeric CS were engineered: CS-HA1DGlu-Asp, in which the 14 acidic residues [-Glu-(Asp)5-Glu-(Asp)7-] of the COOH-terminal tail were removed, and CS-HA1D49COOH, in which the last, mostly acidic, 49 residues of the COOH terminus were removed. Both mutant cDNAs were transiently transfected in HeLa cells, myoblasts of rat skeletal muscle primary cultures, or regenerating soleus muscle fibers of adult rats. The expression and intracellular localization of CS-HA1 mutants were studied by epifluorescence microscopy with use of antibodies against CS or HA1. CS-HA1 mutants were shown to be expressed, sorted, and correctly segregated to jSR. Thus short or long deletions of the COOH-terminal acidic tail do not influence the targeting mechanism of CS
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