171,463 research outputs found
Filling data for tool-path optimisation in 3D printing
No full textData for the test instances in the paper: Volpato, N.; Galvão, L. C ; Nunes, L. F. ; Souza, R. I.; Oguido, K. Combining heuristics for tool-path optimisation in material extrusion additive manufacturing. Journal of the Operational Research Society, 2019 https://doi.org/10.1080/01605682.2019.159013
Shear-induced particle segregation in binary mixtures: Verification of a percolation theory
No full textGranular materials composed of different-sized grains may experience undesired segregation. Segregation is detrimental for a lot of industries because it leads to an increase in production costs and wastes. For these reasons, the segregation phenomena have been intensively studied in the last decades, and a lot of models have been provided by many researchers. However, these models are mainly based on empirical relations rather than physical considerations. This paper aims to confirm the main assumptions made by Volpato, Tirapelle, and Santomaso (2020) in their percolation theory by means of DEM simulations. The simulated geometry is a tilting shear box filled with few tracer particles in a bed of coarser sized grains, and simulations are performed for a range of tilting frequencies and size ratios. The results provide meaningful insight on the mathematical model parameters and allow us to say that the percolation theory relies on physically consistent assumptions
A moralidade vinculada à ação comunicativa e ao direito em Habermas
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas, Programa de Pós-graduação em Filosofia, Florianópolis, 2010Neste trabalho investigar-se-á a moralidade proposta por Jürgen Habermas no sentido de determinar a relação desta com a ação comunicativa e com o sistema jurídico defendidos por este autor. Para isso, inicialmente, se verificará por que esse autor considera que sua ação comunicativa é capaz de obter consensos racionais como solução para conflitos, entre eles, conflitos morais. O que implica, entre outras coisas, na demonstração do princípio universal de sua ética e o que defende por princípio do discurso. Este último definido por ele como necessário de ser respeitado não só na solução de conflitos morais, mas também na solução do que essa teoria compreende por conflitos éticos e por conflitos pragmáticos. Tal defesa, conforme se observará aqui, é um dos quesitos que essa teoria respeita para vincular os conteúdos justificados por meio dela à condição histórica dos indivíduos sobre os quais se aplica. Investigar-seá a análise habermasiana de críticas de Hegel a Kant para verificar por que essa ética considera essa vinculação necessária para a efetivação dos seus consensos morais, bem como também para verificar por que Habermas considera que realiza essa vinculação. Porém, a pluralidade cultural presente nas sociedades pós-tradicionais obriga a este autor lançar mão de um sistema jurídico para a moralidade se realizar nessas. Analisar-se-á aqui esse sistema de modo a se verificar como esse possibilita o uso da argumentação racional para a obtenção de suas normas, o que implica na compreensão do princípio democrático habermasiano, e de como, por meio da coação jurídica, contribui para a efetivação e para a própria obtenção dessas normas de modo que a moralidade seja respeitada nesses processos.This thesis investigated the morality as proposed by Jürgen Habermas in order to determine its relation to communicative action and the legislative system, as defended by the author. To achieve that, at first, the author's observation was verified to comprehend why he believes communicative action can obtain rational consensus as conflict solution, such as, moral conflicts. What has been brought about as a consequence to Habernas demonstration of ethics universal principle, which he defends as discourse principle: defined as necessary of respect, not only to solve moral conflicts, but also, to solve what the theory comprehends as ethical and pragmatical conflicts. Such argument has been observed as one of the aspects employed in the theory to bond the defended contents over which it is applied. Hebermas analysis on Hegel's and Kant's critiques was also investigated to verify why does ethics consider the correlation necessary to moral consensus effectiveness, as well as to verify why does it consider and performs this correlation. However, post-traditional societies cultural plurality has required the author to account for a legislative system to moralitys achievement on such contexts. This system was analyzed in order to verify the formulation of possibilities of rational argumentation to obtain its rules, which implied on the understanding of Habermas democratic principle as well as on how judicial coercion contributes to these rules effectiveness and achievement so that morality came to be respected in these processes
Grand Theft Auto is a “Sandbox” Game, but There are Weapons, Criminals, and Prostitutes in the Sandbox: Response to Ferguson and Donnellan (2017)
No full textIn this issue, (Ferguson, C. J., & Donnellan, B. D., Journal of Youth and and Adolescence, published online 21 June 2017) criticize one of our studies (Gabbiadini, A., Riva, P., Andrighetto, L., Volpato, C., & Bushman, B. J., PLoS ONE, 11: 1-14, 2016) that found violent sexist video games can reduce empathy for female violence victims in male players who identify with violent male game characters, and do so by increasing masculine beliefs. Their main criticism is a "straw person" argument built on a claim that we never made (i.e., a direct effect of sexist-violent video games on empathy). They also made several other criticisms of our article. We appreciate the opportunity to respond to their criticisms in this article. We also point out some flaws in their reanalysis. Despite their criticisms, the core contributions of our original article remain intact
Per una psicologia sociale della letteratura. Relazioni interpersonali e intergruppi in L'erba canta di Doris Lessing
No full textWomen and family relationships in cultural transition. An analysis of autobiographic texts
No full textRelazioni interpersonali e testi letterari. Il tema dell'amicizia ne I Mandarini di Simone De Beauvoir
No full textHigher genus superstring amplitudes and the measure on the moduli space
No full textRecent derivations of completely gauge-invariant two-loop superstring amplitudes renewed the interest in the possible form of higher genus contributions. In this respect, two main points are discussed: a. At genus greater than 3, the Schottky problem actually represents a formidable obstruction for the explicit expression of the integration measure on the moduli space in terms of Riemann period matrices. As a first step toward such a construction, a modular invariant measure for all genera is derived, corresponding to the restriction to the Schottky locus of the Siegel metric on the upper half-space. b. A class of natural generalizations of the 2 loop D'Hoker and Phong formula is discussed for the higher genus contributions to the 4-gravitons amplitude in type II theories. Such expressions also satisfy the non-trivial requirements of modular invariance and gauge slice independence. © 2007 WILEY-VCH Verlag GmbH & Co. KGaA
Tailoring Targeted Therapy to Individual Patients: Lessons to be Learnt from the Development of Mitomycin C
No full textThe modern era of targeted therapeutics offers the potential to tailor therapy to individual patients whose tumours express a specific target. Previous attempts to forecast tumour response to conventional chemotherapeutics based on similar principles have however been disappointing. Mitomycin C (MMC), for example, is a bioreductive drug that requires metabolic activation by cellular reductases for activity. The enzyme NAD(P)H:Quinone oxidoreductase-1 (NQO1) can reduce MMC to DNA damaging species but attempts to establish the relationship between tumour response to MMC and NQO1 expression have generated conflicting reports of good and poor correlations. Several other reductases are known to activate MMC. This, in conjunction with the fact that various physiological and biochemical factors influence therapeutic response, suggests that the mechanism of action of MMC is too complex to allow tumour response to be predicted on the basis of a single enzyme. Alternative approaches using more complex biological and pharmacological systems that reflect the spectrum of reductases present within the tumour have been developed and it remains to be seen whether or not the predictive value of these approaches is enhanced. With regards to targeted therapeutics, the experience with MMC suggests that prediction of tumour response based on analysis of a single target may be too simplistic. Multiple mechanisms of action and the influence of tumour microenvironment on cell biology and drug delivery are likely to influence the final outcome of therapy. The challenge for the future progression of this field is to develop assays that reflect the overall biological and pharmacological processes involved in drug activation whilst retaining the simplicity and robustness required for routine chemosensitivity testing in a clinical setting
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