102,805 research outputs found
Gas entropy in a representative sample of nearby X-ray galaxy clusters (REXCESS): relationship to gas mass fraction
No full textWe examine the radial entropy distribution and its scaling using 31 nearby galaxy clusters from the representative XMM-Newton cluster structure survey (REXCESS), a sample in the temperature range 2-9 keV selected in X-ray luminosity only, with no bias toward any particular morphological type. The entropy profiles are robustly measured at least out to R1000 in all systems and out to R500 in thirteen systems. Compared to theoretical expectations from non-radiative cosmological simulations, the observed distributions show a radial and mass-dependent excess entropy, such that the excess is greater and extends to larger radii in lower mass systems. At R500, the mass dependence and entropy excess are both negligible within the large observational and theoretical uncertainties. Mirroring this behaviour, the scaling of gas entropy is shallower than self-similar in the inner regions, but steepens with radius, becoming consistent with self-similar at R500. There is a large dispersion in scaled entropy in the inner regions, apparently linked to the presence of cool cores and dynamical activity; at larger radii the dispersion decreases by approximately a factor of two to 30 per cent, and the dichotomy between subsamples disappears. There are two peaks in the distribution of both inner slope and, after parameterising the profiles with a power law plus constant model, in central entropy K0. However, we are unable to distinguish between a bimodal or a left-skewed distribution of K0 with the present data. The distribution of outer slopes is unimodal with a median value of 0.98, and there is a clear correlation of outer slope with temperature. Renormalising the dimensionless entropy profiles by the gas mass fraction profile fgas (<R), leads to a remarkable reduction in the scatter, implying that gas mass fraction variations with radius and mass are the cause of the observed entropy structural and scaling properties. The results are consistent with the picture of a cluster population in which entropy modification is centrally concentrated and extends to larger radii at lower mass, leading to both a radial and a mass-dependence in the gas mass fraction, but which is increasingly self-similar at large radius. The observed normalisation, however, would suggest entropy modification at least up to R1000, and even beyond, in all but the most massive systems. We discuss a tentative scenario to explain the observed behaviour of the entropy and gas mass fraction in the REXCESS sample, in which a combination of extra heating and merger mixing maintains an elevated central entropy level in the majority of the population, and a smaller fraction of systems is able to develop a cool core. <br/
Applying and Extending the Sustainable Value Method related to Agriculture – an Overview
No full textSustainable Value is a method to measure the contribution of an economic entity, such as a farm or the entire agricultural sector, towards the sustainability (sustainable development) of a region, a country or on a global scale. A positive sustainable value is created once resources are used more efficiently than by a benchmark. It shows the excess return that is created or lost by the use of economic, environmental and social resources by an economic entity relative to a benchmark. The purpose of this paper is to give an overview on the characteristics and requirements of the SV and to provide information on (a) possible applications and (b) extensions of the SV method related to the agricultural sector. A particular emphasis is put on the choice of sustainability indicators (resource figures, welfare figure) to be included, the generic steps of SV calculation, the meaning of weighting and aggregation in the SV, the role of the Return-to-Cost Ratio in taking farm size into consideration, and the interpretation and communication of the results of an agriculture-related SV assessment. After sketching out possible extensions and variations of the SV method, the paper closes with a summary of those aspects to keep in mind when applying the SV to agriculture.sustainability contributions, value, measurement, Environmental Economics and Policy,
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Real-time cardiovascular magnetic resonance at 1.5 T using balanced SSFP and 40 ms resolution
No full textBackground: While cardiovascular magnetic resonance (CMR) commonly employs ECG-synchronized cine acquisitions with balanced steady-state free precession (SSFP) contrast at 1.5 T, recent developments at 3 T demonstrate significant potential for T1-weighted real-time imaging at high spatiotemporal resolution using undersampled radial FLASH. The purpose of this work was to combine both ideas and to evaluate a corresponding real-time CMR method at 1.5 T with SSFP contrast. Methods: Radial gradient-echo sequences with fully balanced gradients and at least 15-fold undersampling were implemented on two CMR systems with different gradient performance. Image reconstruction by regularized nonlinear inversion (NLINV) was performed offline and resulted in real-time SSFP CMR images at a nominal resolution of 1.8 mm and with acquisition times of 40 ms. Results: Studies of healthy subjects demonstrated technical feasibility in terms of robustness and general image quality. Clinical applicability with access to quantitative evaluations (e.g., ejection fraction) was confirmed by preliminary applications to 27 patients with typical indications for CMR including arrhythmias and abnormal wall motion. Real-time image quality was slightly lower than for cine SSFP recordings, but considered diagnostic in all cases. Conclusions: Extending conventional cine approaches, real-time radial SSFP CMR with NLINV reconstruction provides access to individual cardiac cycles and allows for studies of patients with irregular heartbeat
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Pelevin’s Trinity in the novel “t”: author – protagonist – reader
No full textThe article attempts to interpret Pelevin's artistic strategy in the novel "T" by exploring its subject organization and addressing the key problems of the author, the protagonist, and the reader as they are seen by the researcher. The article analyzes the peculiarities of constructing the narrative reality in the novel "T", and goes on to discuss Pelevin's philosophic models of the development of the humankind, and the emergence of his new anthropology
Real-time magnetic resonance imaging: Radial gradient-echo sequences with nonlinear inverse reconstruction.
No full textObjective The aim of this study is to evaluate a real-time magnetic resonance imaging (MRI) method that not only promises high spatiotemporal resolution but also practical robustness in a wide range of scientific and clinical applications. Materials and Methods The proposed method relies on highly undersampled gradient-echo sequences with radial encoding schemes. The serial image reconstruction process solves the true mathematical task that emerges as a nonlinear inverse problem with the complex image and all coil sensitivity maps as unknowns. Extensions to model-based reconstructions for quantitative parametric mapping further increase the number of unknowns, for example, by adding parameters for phase-contrast flow or T1 relaxation. In all cases, an iterative numerical solution that minimizes a respective cost function is achieved with use of the iteratively regularized Gauss-Newton method. Convergence is supported by regularization, for example, to the preceding frame, whereas temporal fidelity is ensured by downsizing the regularization strength in comparison to the data consistency term in each iterative step. Practical implementations of highly parallelized algorithms are realized on a computer with multiple graphical processing units. It is "invisibly" integrated into a commercial 3-T MRI system to allow for conventional usage and to provide online reconstruction, display, and storage of regular DICOM image series. Results Depending on the application, the proposed method offers serial imaging, that is, the recording of MRI movies, with variable spatial resolution and up to 100 frames per second (fps)-corresponding to 10 milliseconds image acquisition times. For example, movements of the temporomandibular joint during opening and closing of the mouth are visualized with use of simultaneous dual-slice movies of both joints at 2 x 10 fps (50 milliseconds per frame). Cardiac function may be studied at 30 to 50 fps (33.3 to 20 milliseconds), whereas articulation processes typically require 50 fps (20 milliseconds) or orthogonal dual-slice acquisitions at 2 x 25 fps (20 milliseconds). Methodological extensions to model-based reconstructions achieve improved quantitative mapping of flow velocities and T1 relaxation times in a variety of clinical scenarios. Conclusions Real-time gradient-echo MRI with extreme radial undersampling and nonlinear inverse reconstruction allows for direct monitoring of arbitrary physiological processes and body functions. In many cases, pertinent applications offer hitherto impossible clinical studies (eg, of high-resolution swallowing dynamics) or bear the potential to replace existing MRI procedures (eg, electrocardiogram-gated cardiac examinations). As a consequence, many novel opportunities will require a change of paradigm in MRI-based radiology. At this stage, extended clinical trials are needed
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