1,721,019 research outputs found
Perampanel as add-on therapy in epilepsies with known etiology: A single center experience with long-term follow-up
Full text linkWe report a retrospective monocentric study performed on 63 patients affected by epilepsy with known
etiology, receiving perampanel as add-on therapy with at least 12-month follow-up. The purpose of our
study was to evaluate efficacy and tolerability of perampanel in this group of epilepsies. Patients were
classified into 2 groups based on the presence/absence of a single focal brain lesion on MRI, as epilepsy
etiology: 48 subjects were affected by focal lesional epilepsy and 15 by non-focal lesional epilepsy. The
retention rate was 76.2% and 53.9% at 12 and 24 months respectively. At 12 months, at least 40% of
patients resulted responders, with a significant reduction in seizure frequency (p = 0.01), confirmed at
24 months. Considering epilepsy etiology, we found a better PER response in patients with focal lesional
epilepsy. A significant correlation was observed between responder rates and EEG pattern. Only 30% of
patients reported mild-moderate adverse events. Efficacy and tolerability of PER, in our study, are in line
with the results reported in other real-world studies. Our data suggest the possibility of better PER
response in patients with focal brain lesions, which indicates that this drug could be a therapeutic option
in this population
Peculiar EEG signatures, ictal drinking and long-term follow-up in anti-LGI1 encephalitis
No full textAnti-Ma-associated encephalomyeloradiculopathy in a patient with pleural mesothelioma.
No full text[no abstract available
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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