1,721,054 research outputs found
Trattato di chirurgia ostetrica e ginecologica
No full textL’endometriosi è una malattia benigna e cronica caratterizzata dalla presenza di tessuto endometriale funzionale
(ghiandole endometriali e stroma) al di fuori dell’utero (1). La presenza di malattia endometriosica è un problema sociale significativo, in quanto causa nelle donne affette deficit di fertilità, dolore pelvico cronico, dispareunia, disuria e dischezia (2).
Con il termine neuropelveologia si intende quel complesso di pratiche mediche che si occupano delle patologie che interessano l’innervazione pelvica nel suo complesso. La disciplina, nata da un’intuizione di Possover all’inizio degli anni 2000, ha preso prepotentemente piede negli ultimi anni come sub-specialità trasversale ai normali campi di interesse delle patologie della pelvi (ginecologia, urologia, colo-proctologia, ortopedia ecc.
Primary vaginal leiomyosarcoma, a rare tumour: case report and review
Full text linkPrimary vaginal leiomyosarcomas (pvLMS) are rare, recurrent tumours accounting
for ca. 2% of all vaginal cancers. The etiology is still unknown, the prognosis is poor
and there is no consensus guideline on its management. Diagnosis is usually made
during the 5th decade due to the presence of a vaginal mass or nodule [1-2]. Current
medical literature reports about 200 cases (PubMed®); only 3 studies have considered
the ultrastructure [2-4]. Herein a pvLMS is presented and discussed. A nodular, 25 x
23 x 28 mm-mass, infiltrating the urethra but not the rectovaginal septum, was widely
excised from the superior vaginal wall of a 58-year-old previously hysterectomized
woman. Macroscopic images and MRI were performed. Iliac lymph nodes and HMB45
were negative. The sample was fixed and prepared for light microscopy, transmission
(TEM) and scanning (SEM) electron microscopy. Semithin sections showed
a storiform pattern of spindle shaped cells with blunt-ended nuclei. Cells arranged
in interwoven fascicles within a dense and richly vascularised stroma (neoangiogenesis).
Some atypic mitotic figures and focal necrosis were seen. SEM evidenced a
dense collagenous stroma with numerous microvessels. TEM showed neoplastic and
pleomorphic cells with complex cytoplasm projections containing paranuclear crowds
of dilated mitochondria, free ribosomes and a well-developed rough endoplasmic
reticulum. Nuclei were large, mostly hyperchromatic, usually indented, with prominent
nucleoli and nucleolonema. The dense intercellular space contained dense bundles
of collagen fibers. A high and reactive endothelium lined blood vessels. After 4
follow-ups, the patient is fine and without recurrence. Best outcomes occur when the
tumour is small, localized, and can be removed surgically with wide, clear margins,
as it was for this case. As there are different kinds of LMS, biopsy followed by immunohistochemistry
and electron microscopy still represents a good diagnostic choice.
References
[1] Umeadi et al. (2008) Vaginal leiomyosarcoma. J Obstet Gynaecol 28(5): 553-554.
[2] Tobon et al. (1973) Primary leiomyosarcoma of the vagina. Light and electron microscopic observations.
Cancer 32(2): 450-457.
[3] Akhtar et al. (1978) Primary leiomyosarcoma of the vagina: light and electron microscopic study of
a case with review of literature. Tex Med 74(9): 67-71.
[4] Rastogi et al. (1984) Primary leiomyosarcoma of the vagina: a study of five cases. Gynecol Oncol
18(1): 77-86
Sentinel node mapping in endometrial cancer
Full text linkNodal status is one of the most important prognostic factors for patients with apparent early stage endometrial cancer. The role of retroperitoneal staging in endometrial cancer is controversial. Nodal status provides useful prognostic data, and allows to tailor the need of postoperative treatments. However, two independent randomized trials showed that the execution of (pelvic) lymphadenectomy increases the risk of having surgery-related complication without improving patients' outcomes. Sentinel node mapping aims to achieve data regarding nodal status without increasing morbidity. Sentinel node mapping is the removal of first (clinically negative) lymph nodes draining the uterus. Several studies suggested that sentinel node mapping is not inferior to lymphadenectomy in identifying patients with nodal disease. More importantly, thorough ultrastaging sentinel node mapping allows the detection of low volume disease (micrometastases and isolated tumor cells), that are not always detectable via conventional pathological examination. Therefore, the adoption of sentinel node mapping guarantees a higher identification of patients with nodal disease than lymphadenectomy. Further evidence is needed to assess the value of various adjuvant strategies in patients with low volume disease and to tailor those treatments also on the basis of the molecular and genomic characterization of endometrial tumors
Feasibility of single-port robotic lumbo-aortic lymphadenectomy for ovarian cancer
No full textNot Availabl
Robotic Single-Port Versus Robotic Single-Site Hysterectomy in Early Endometrial Cancer: A Case Control Study
No full textObjective To compare surgical outcomes of robotic single-port (RSPH) versus single-site (RSSH) hysterectomy in early-stage endometrial cancer.Methods This is a retrospective case-control study, comparing surgical outcomes of RSPH (Cases) and RSSH (Controls) in early-stage endometrial cancer.Results Twenty-five women who underwent RSPH from June 2024 to November 2024 were matched with 50 historical RSSH controls treated at the same institution by the same surgical team between December 2011 and September 2014. Operation time was similar: 110 min in RSPH and 99 min in RSSH (p = 0.76). Blood loss was 50 mL in RSPH and 60 mL in RSSH (p = 0.14). Hospital stay was shorter in RSSH (3.5 days in RSPH and 3 days in RSSH, p = 0.001).Conclusions Our study confirms the safety and feasibility of RSPH for endometrial cancer without major differences from the RSSH in terms of surgical outcomes
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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