1,721,007 research outputs found
Quantification of pilomotor nerves: a new tool to evaluate autonomic involvement in diabetes.
No full text
Comparison of the safety and efficacy of delapril with enalapril in patients with congestive heart failure
No full textIncremento della prevalenza di obesità e diabete nella popolazione anziana durante gli anni novanta.
No full textEffect of losartan in treatment of exercise-induced myocardial ischemia.
No full textBecause no controlled clinical studies are available about the possible role of angiotensin II
receptor blockers in preventing effort myocardial ischemia, we evaluated the effect of
angiotensin II receptor blocker/losartan in preventing exercise-induced myocardial ischemia
in patients with coronary artery disease. Twenty-four sedentary patients with chronic
stable ischemia were prospectively randomized to 28 days (double blind) of losartan 100 mg
or losartan placebo in 2 divided doses. In each patient the treatment was crossed over to the
alternative regimen (28 days, double blind) after a 1-week placebo period (single blind). At
the end of each phase a new exercise stress test was performed. At baseline, systolic blood
pressure was significantly decreased after losartan 100 mg compared with losartan placebo.
At submaximal exercise, systolic blood pressure and rate–pressure product were lower after
losartan 100 mg administration compared with losartan placebo, and these findings remained
significant at 1-mm ST depression and at peak exercise. Losartan 100 mg administration
versus losartan placebo significantly delayed the time to 1-mm ST-depression
onset and decreased ST-segment depression at peak exercise and time to recovery of
ST-segment depression. Losartan 100 mg administration compared with losartan placebo
was able to significantly increase exercise duration and maximal workload during exercise
stress testing. In conclusion, in our study, losartan decreased electrocardiographic parameters
of myocardial ischemia in patients with coronary artery disease, suggesting a possible
role of this drug in treatment of patients with effort myocardial ischemia
Analysis of dystrophin gene deletions indicates that the hinge III region of the protein correlates with disease severity
No full textWe have investigated the frequency of deletions in the dystrophin gene in 108 unrelated Duchenne and Becker muscular dystrophy (DMD/BMD) patients from southern Italy (DMD, n. 47; BMD, n. 61) and identified 89 deletions. The de novo mutation rate (about 30%), and the preferentially maternal origin of deletional mutations, analysed in families in which the maternal grandparents were available or their haplotypes could be unequivocally reconstructed, are in agreement with data reported for other populations. The correlation between BMD phenotype and type of deletion suggests that, in the distal rod domain region, the deletion size may not be as crucial as the particular combination of missing exons. In fact, we provide immunohistochemical and clinical evidence that in-frame deletion of the hinge III region in the distal rod domain results in a milder phenotype as compared with shorter deletions that do not include the hinge III region. Our data obtained in BMD patients, by confirming inferences arising from minigene transfection experiments in mdx mice, represent an important contribution to gene therapy approaches
Portal vein pulsatility ratio provides a measure of right heart function in chronic heart failure.
No full textPortal vein pulsatility ratio provides a measure of right heart function in chronic heart failure.
No full textMyocardial ultrasonic tissue characterization in pediatric and adult patients with hypertrophic cardiomyopathy
No full text- …
