1,721,087 research outputs found
Architettura razionale, 1973-2008 F Visconti, R Capozzi - 2008 - Clean Cited by 1 Related articles All 2 versions
No full textcitazione del libro Architettura italiana, anni 60 in Architettura razionale, 1973-2008
F Visconti, R Capozzi - 2008 - Clean
Cited by 1 Related articles All 2 version
New insights on oxidative stress in cancer.
No full textCancer initiation and progression has been linked to oxidative stress, a condition in which the balance between production and disposal of reactive oxygen or nitrogen species is altered. Oxidative stress has several protumorigenic effects, such as increasing DNA mutation rate or inducing DNA damage, genome instability and cell proliferation. Conversely, oxidative stress also exerts antitumorigenic actions, and it is has been linked to senescence and apoptosis, two major mechanisms that counteract tumor development. In this review, recent findings that relate oxidative stress to cancer-associated conditions, such as chronic inflammation, steroid hormone signaling and altered chromosome segregation, are highlighted, and how these studies may identify new targets for the development of drugs and strategies for cancer prevention and cure is discussed
Sustaining the Spindle Assembly Checkpoint to improve cancer therapy
Full text linkTo prevent chromosome segregation errors, the spindle assembly checkpoint (SAC) delays mitosis exit until proper spindle assembly. We found that the FCP1 phosphatase and its downstream target WEE1 kinase oppose the SAC, promoting mitosis exit despite malformed spindles. We further showed that targeting this pathway might be useful for cancer therapy
Digital platforms and big data-driven sustainable innovation in smart healthcare investments
No full textLatest Organisation for Economic Co-operation and Development (OECD) figures show that health spending grew by less than 2% in 2017 with provisional estimates pointing to around 2.5% growth in 2018. OECD spending on health as a share of Gross Domestic Product (GDP) remained at around 8.8% on average in 2017, according to OECD Health Statistics 2019, updated in November 2019. This is due to factors like ageing population and faces public budget constraints that force countries to find out innovative solutions. Sustainable technological advances are so essential to make infrastructural healthcare investments “smart”. Healthcare is a core pillar of the socio-economic ecosystem, and it can strongly benefit from digital investments. Digital healthcare solutions, such as software or internet-connected devices created for detection or treatment of medical indications, are creating a digital disruption in healthcare. New research indicates that digital health solutions will save the American healthcare system more than $100 billion over the next four years. Technological innovation can strongly benefit from the alliance between public and private partners: while the former provides (in most developed countries) universal healthcare coverage, the latter are an indispensable partner for their skills and expertise. Remuneration of private engagement may conveniently follow pay-for-performance patterns and investments are increasingly patient centric. Digitalization is a key factor, since it can transform, for many chronical diseases, in-patients into out-patients and eventually home-patients, with strong economic savings and meaningful life quality improvements.
Digitalization is a main driver of m-health or e-health strategies. M-health is most commonly used in reference to using mobile communication devices, such as mobile phones, tablet computers and PDAs, and wearable devices such as smart watches, for health services, information, and data collection. Public authorities can choose between several options when they want to build new hospitals, ranging from Traditional Procurement to Public-Private Partnerships typically backed by Project Finance schemes. Within this evolutionary framework, this paper examines with an interdisciplinary approach which is the possible impact of digitalization on healthcare infrastructural investment. A primary input factor is represented by big data (often ignited by Internet of Things wearables) that can be collected in real-time, stored in cloud, and eventually processed with artificial intelligence (machine learning) paradigms, fueling interoperable databases and easing the safe exchange of sensitive information with blockchain applications. In this synergistic process, digitalization works as a catalyzer that eases cooperation among different stakeholders. To the extent that the primary stakeholders (the public player, private investors with their sponsoring banks, patients, etc.) cooperate using digital platforms as an exchanging interface, they can co-create additional value that can soften the aforementioned public budget constraints. Additional value for money is a by-product of this virtuous cycle and it can be conveniently apportioned among the stakeholders. Check-and-balance factors can prevent excessive private rents, for instance through increased competition. A win-win strategic model may so be designed around a patient-centric and public vision. This comprehensive evolutionary vision has seldom been treated in the current literature. In particular, healthcare supply chain bottlenecks have hardly been considered with a technological approach that takes into account also the socio-economic implications. This paper proposes some feasible solutions for overcoming some of these criticalities, fostering resilience and long-term sustainability. A case study, generalized from a real sample of healthcare infrastructural investments, will show how a typical Project Finance business model (for the construction and management of a new hospital) can react to the introduction of digitalization and big data. A sensitivity analysis will show which are the potential economic and financial gains, in terms of improved marginality. A further analysis will concern evolutionary trends that may be considered with stochastic modeling that incorporate real-time big data to re-engineer the business plan. The study will also consider the interaction between supply and value chain when the healthcare model “goes digital”. The paper will analyze in its discussion section some trendy research streams that can ignite future investigation, concerning, for instance, digital B2B/B2C interactions among the players that share a common 24/7 marketplace. Further research avenues will be synthetically recalled in the discussion, concerning, for instance, cyber-security challenges. To the authors’ best knowledge, there are no comprehensive studies that analyze the research question of this paper. The research is innovative, and it might shed some light both on the traditional stakeholder relationships, re-engineered around digital platforms, and on the specific healthcare sector, looking for patient-centered satisfaction and sustainability
Requirement for proteolysis in spindle assembly checkpoint silencing.
No full textAnaphase initiation requires ubiquitin-dependent proteolysis of crucial substrates through activation of the ubiquitin ligase Anaphase promoting Complex/Cyclosome (ApC/C) in association with its coactivator Cdc20. To prevent chromosome segregation errors, effector proteins of a safeguard mechanism called spindle assembly checkpoint (SAC), Mad2 and BubR1, bind Cdc20 and restrain ApC/C(Cdc20) activation until spindle assembly. Coordinated chromosome segregation also requires timely SAC inactivation. Spindle assembly appears necessary to silence SAC, however, how resolution of the SAC effector branch is achieved is still largely unknown. We show here that the complex between Mad2 and Cdc20 peaked at prometaphase in mammalian cells, while its dissociation proceeded along with spindle assembly and required proteolysis. proteolysis did not appear required for assembly of metaphase spindles but rather needed for Mad2-Cdc20 complex resolution by promoting reversal of phosphorylations that maintain the complex. Indeed, in the absence of proteolysis, Mad2-Cdc20 complex dissociation was reversed by treatment with cyclin-dependent kinase or Aurora kinase inhibitors. Mad2-Cdc20 disassembly was, however, resistant to the potent pp1 and pp2A phosphatases inhibitor okadaic acid. We propose that SAC silencing in mammalian cells requires proteolysis-dependent activation of okadaic acid-resistant phosphatase(s) to reverse phosphorylations that lock the Mad2-Cdc20 complex
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Healthcare Digitalization and Pay-For-Performance Incentives in Smart Hospital Project Financing
Full text linkThis study aims to explore the impact of healthcare digitalization on smart hospital project financing (PF) fostered by pay-for-performance (P4P) incentives. Digital platforms are a technology-enabled business model that facilitates exchanges between interacting agents. They represent a bridging link among disconnected nodes, improving the scalable value of networks. Application to healthcare public–private partnerships (PPPs) is significant due to the consistency of digital platforms with health issues and the complexity of the stakeholder’s interaction. In infrastructural PPPs, public and private players cooperate, usually following PF patterns. This relationship is complemented by digitized supply chains and is increasingly patient-centric. This paper reviews the literature, analyzes some supply chain bottlenecks, addresses solutions concerning the networking effects of platforms to improve PPP interactions, and investigates the cost–benefit analysis of digital health with an empirical case. Whereas diagnostic or infrastructural technology is an expensive investment with long-term payback, leapfrogging digital applications reduce contingent costs. “Digital” savings can be shared by key stakeholders with P4P schemes, incentivizing value co-creation patterns. Efficient sharing may apply network theory to a comprehensive PPP ecosystem where stakeholding nodes are digitally connected. This innovative approach improves stakeholder relationships, which are re-engineered around digital platforms that enhance patient-centered satisfaction and sustainability. Digital technologies are useful even for infectious disease surveillance, like that of the coronavirus pandemic, for supporting massive healthcare intervention, decongesting hospitals, and providing timely big data
Type 1 IFNs and regulation of TH1 responses: enigmas both resolved and emerge
No full textSTATs are critical in immune responses to type I IFNs. The human and mouse pathways differ, partly due to differences in STAT2, but unpredicted responses after viral infections raise new questions
- …
