1,720,976 research outputs found
Human bocavirus (HBoV) role in lower respiratory tract diseases and acute gastroenteritis pathogenesis in children
No full textDziļāko elpceļu slimības un akūts gastroenterīts ir galevnais cēlonis bērnu saslimšanai un mirstībai visā pasaulē. Arī Latvijas bērnu populācijā šīs slimības ir bieži sastopamas, tomēr ne vienmēr ir zināms šo slimību etioloģiskais aģents. Cilvēka bokavīruss (HBoV) ir 2005. gadā atklāts parvovīruss, ko saista ar elpceļu slimību un akūta gastroenterīta izraisīšanu bērniem. Šī pētījuma mērķis bija noskaidrot HBoV iesaisti dziļāko elpceļu slimību un akūta gastroenterīta patoģenēzē hospitalizētiem bērniem. Šajā pētījumā 46,03% bērnu ar dziļāko elpceļu slimībām un 16,67% bērnu ar akūtu gastroenterītu detektēta HBoV genoma sekvences klātbūtne organismā. Sekvencējot noteikts, ka pacientiem ar dziļāko elpceļu slimībām sastopams HBoV1, savukārt pacientiem ar akūtu gastroenterītu – HBoV2 un HBoV3. Akūta HBoV1 infekcija konstatēta 13 bērniem ar dziļāko elpceļu slimībām. Secinājums: Bērniem ar dziļāko elpceļu slimībām konstatē HBoV1 genoma sekvences klātbūtni organismā, bet pacientiem ar gastroenterītu – HBoV2 un HBoV3. Atsevišķos gadījumos HBoV1 izraisa smagas elpceļu slimības bērniem, savukārt HBoV2 un HBoV3 iesiaste gastroenterīta etiopatoģenēzē nav pierādīta. Atslēgvārdi: HBoV1-3, dziļāko elpceļu slimības, akūts gastroenterīts, bērni.Lower respiratory tract diseases and acute gastroenteritis is the main cause of children morbidity and mortality worldwide. These diseases are also commonly found in children population in Latvia however the etiological agent of these diseases is not always known. Human bocavirus (HBoV) is a parvovirus discovered in 2005, which is associated with respiratory tract diseases and acute gastroenteritis in children. The aim of this study was to determine HBoV involvment in lower respiratory tract diseases and acute gastroenteritis pathogenesis in hospitalized children. In this study, HBoV genome sequence was detected in 46.03% of children with lower respiratory tract diseases, and in 16.67% of children with acute gastroenteritis. By sequencing it was determined that HBoV1 is present in patients with lower respiratory tract diseases, while HBoV2 and HBoV3 in patients with acute gastroenteritis. Acute infection of HBoV1 was detected for 13 children with lower respiratory diseases. Conclusion: HBoV1 genome sequence is present in children with lower respiratory tract diseases, but in patients with gastroenteritis - HBoV2 and HBoV3. In certain cases HBoV1 causes severe respiratory tract diseases in children while HBoV2 and HBoV3 involvment in gastroenteritis etiopathogenesis is not proven. Keywords: HBoV1-3, lower respiratory tract diseases, acute gastroenteritis, children
Human bocavirus involvement in lower respiratory tract desease patogenesis in children
No full textDziļo elpceļu slimības, ko var izraisīt vīrusu infekcija, ir biežs cēlonis bērnu saslimšanai pasaulē un Latvijā. Cilvēka bokavīrusa pirmais tips (HBoV1) ir viens no iespējamajiem infekciozajiem aģentiem, tomēr tā loma slimību izraisīšanā joprojām ir neskaidra.
Šī pētījuma mērķis bija noskaidrot HBoV1 iesaisti un sastopamību dziļā respiratorā trakta infekcijas gadījumā bērniem, kuri hospitalizēti ar akūtu dziļā respiratorā trakta infekciju.
Lietojot polimerāzes ķēdes reakciju (PĶR), HBoV1 genoma sekvences klātbūtne konstatēta 33,33% pārbaudītajiem pacientiem.
Secinājums: HBoV1 varētu būt patogēns elpceļu slimību gadījumā, jo šī vīrusa genoma sekvences klātbūtne, ko pavada augsta vīrusa slodze bez koinfekcijas ar citiem patogēniem, bieži konstatēta bērniem, kuri hospitalizēti ar akūtu dziļā respiratorā trakta infekciju.
Atslēgvārdi: HBoV1, dziļā respiratorā trakta infekcija, PĶR, reālā laika PĶR, RT-PĶR.Lower respiratory tract diseases, which can be caused by virus infection, is common cause of children morbidity around the world and in Latvia. Human bocavirus type one (HBoV1) is one of the possible infectious agents, though its role in causing the diseases is still unclear.
The aim of this study was to determine the involvement and frequency of HBoV1 in hospitalized children with acute lower respiratory tract infection.
Using polymerase chain reaction (PCR) HBoV1 genome sequence was found in 33.33% of analysed patients.
Conclusion: HBoV1 could be as a pathogen in respiratory tract diseases, due to the frequent detection of the virus genomic sequences, accompanied by a high viral load and absence of co-infections with other pathogens in hospitalized children with acute lower respiratory diseases.
Keywords: HBoV1, lower respiratory tract infection, PCR, real-time PCR, RT–PCR
Prevalence of human herpesvirus infection, immune activation and neurodegenerative markers in patients with relapsing remitting multiple sclerosis
No full textCilvēka herpesvīrusu infekcijas, imūnās aktivācijas un neirodeģenerācijas marķieru sastopamības biežums pacientiem ar recidivējoši remitējošu multiplo skleroziPrevalence of human herpesvirus infection, immune activation and neurodegenerative markers in patients with relapsing remitting multiple sclerosi
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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