4,328 research outputs found

    Stroke in the Emergency Department. Lecture presented at Stroke 2020, Ambulance Victoria x Healthscope Event, 2020 Feb 18, Melbourne, Australia.

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    Lim A. Stroke in the Emergency Department. Lecture presented at: Stroke 2020, Ambulance Victoria x Healthscope Event; 2020 Feb 18; Melbourne, Australia

    Victoria Hotel

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    The rear of the Victoria Hotel, when it was owned by the Lim Family.Chapman, D.Date:193

    Yves-Heng Lim

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    Yves-Heng Lim est enseignant-chercheur au Département d’Etudes de Sécurité et de Criminologie de l’Université Macquarie, Sydney. Il est l’auteur de China’s Naval Power: An Offensive Realist Approach (Ashgate, 2014). Yves-Heng Lim is a lecturer at the Department of Security Studies and Criminology, Macquarie University. He is the author of China’s Naval Power: An Offensive Realist Approach (Ashgate, 2014)

    LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing

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    In recent years there have been major advances with respect to the identification of the protein components and mechanisms of microRNA (miRNA) mediated silencing. However, the complete and precise repertoire of components and mechanism(s) of action remain to be fully elucidated. Herein we reveal the identification of a family of three LIM domain-containing proteins, LIMD1, Ajuba and WTIP (Ajuba LIM proteins) as novel mammalian processing body (P-body) components, which highlight a novel mechanism of miRNA-mediated gene silencing. Furthermore, we reveal that LIMD1, Ajuba, and WTIP bind to Ago1/2, RCK, Dcp2, and eIF4E in vivo, that they are required for miRNA-mediated, but not siRNA-mediated gene silencing and that all three proteins bind to the mRNA 5′ m7GTP cap–protein complex. Mechanistically, we propose the Ajuba LIM proteins interact with the m7GTP cap structure via a specific interaction with eIF4E that prevents 4EBP1 and eIF4G interaction. In addition, these LIM-domain proteins facilitate miRNA-mediated gene silencing by acting as an essential molecular link between the translationally inhibited eIF4E-m7GTP-5′cap and Ago1/2 within the miRISC complex attached to the 3′-UTR of mRNA, creating an inhibitory closed-loop complex

    MobleyLab/benchmarkff: Version 1.0.0: Used in paper

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    This is the version of the code used in our preprint that we've submitted for publication, citation below. Additional changes may be forthcoming at a later date as more folks use this elsewhere, but this is the version we're using at this point. Lim, Victoria T.; Hahn, David F.; Tresadern, Gary; Bayly, Christopher I.; Mobley, David (2020): Benchmark Assessment of Molecular Geometries and Energies from Small Molecule Force Fields. ChemRxiv. Preprint. https://doi.org/10.26434/chemrxiv.12551867.v

    Professional attachment report [with] Chio Lim & Associates.

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    This report serves as a summary of the professional attachment. Besides touching on author experiences working with Chio Lim & Associates (CLA), it wil also touch on other issues before, during and after the program

    Fitting of valence parameters

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    David Mobley, Lee-Ping Wang, and Victoria Lim discuss plans for (and progress towards) fitting of non-torsion valence terms within SMIRNOFF force fields at the Open Force Field Consortium Workshop in San Diego, Jan 8 2019

    Panorama of Darwin from water tower behind Victoria Hotel

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    Panorama of Darwin from water tower behind Victoria Hotel. Looking towards airport. Left to Right. Darwin fruit and vegetable supply (front), E. D'Ambrosio and Co. (centre), Lorna Lim and Sons (front).Mutter, Don

    Lim-inf convergence and its compactness

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    Abstract- We describe the Mizar formalization of the proof of compactness of lim-inf convergence given in [W33] according to [CCL]. Lim-inf convergence formalized in [W28] is a Moore-Smith convergence investigated in [Y6] and involves the concept of nets. The proof is based on the equivalence of two approaches to convergence in topological spaces: filter convergence and Moore-Smith (net) convergence. The equivalence is worked out in [Y19] and different characterizations of compactness are also given there. These efforts are a continuation of the international project of formalizing the theory of continuous lattices headed by the first author

    Gran fiesta del Inti Raymi en La Victoria

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    Gran fiesta del Inti Raymi en La Victoria. Municipalidad de la Victoria / Monumento Manco Cápac / Asociación Cultural Kuntisuyo / Cacharpari / Colegio Pestalozzi - Santiago Antúnez de Mayolo - Isabel La Católica - Felipe Santiago Salaverry - Sagrada Familia / Chinita Cordillerana / Diamante Andino / Verónica Tueros / Asiación Cultural Kuntur Llaqta. Documento que forma parte de la colección documental "Recortes periodísticos del Instituto Nacional de Cultura [LIM-150115-EEC-ART-000-21-06-1997]Dicha información no refleja necesariamente la posición institucional del Ministerio de Cultura
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