347 research outputs found
Supplemental Material, sj-tiff-1-cpt-10.1177_10742484221074585 - The Association of Alanine Aminotransferase Levels With Myocardial Perfusion Imaging and Cardiovascular Morbidity
No full textSupplemental Material, sj-tiff-1-cpt-10.1177_10742484221074585 for The Association of Alanine Aminotransferase Levels With Myocardial Perfusion Imaging and Cardiovascular Morbidity by David Yardeni, Ronen Toledano, Victor Novack, Aryeh Shalev, Arik Wolak, Yaron Rotman and Ohad Etzion in Journal of Cardiovascular Pharmacology and Therapeutics</p
Supplemental Material, sj-tiff-2-cpt-10.1177_10742484221074585 - The Association of Alanine Aminotransferase Levels With Myocardial Perfusion Imaging and Cardiovascular Morbidity
No full textSupplemental Material, sj-tiff-2-cpt-10.1177_10742484221074585 for The Association of Alanine Aminotransferase Levels With Myocardial Perfusion Imaging and Cardiovascular Morbidity by David Yardeni, Ronen Toledano, Victor Novack, Aryeh Shalev, Arik Wolak, Yaron Rotman and Ohad Etzion in Journal of Cardiovascular Pharmacology and Therapeutics</p
Two Randomized, Double-masked, Placebo-controlled Studies of the Local Anesthetic Effect of Articaine Ophthalmic Solution
No full textVictor H Gonzalez,1 David L Wirta,2 Martin Uram,3 Audrey Schupp,4 Michelle Widmann,5 Gary D Novack6,7 1Valley Research Institute, McAllen, TX, USA; 2Eye Research Foundation, Newport Beach, CA, USA; 3American Genomics, LLC, Hobe Sound, FL, USA; 4CMC Turnkey Solutions, Bailey, CO, USA; 5Cal Clinical Solutions, Apex, NC, USA; 6PharmaLogic Development, Inc., San Rafael, CA, USA; 7Department of Ophthalmology & Vision Science, University of California, Davis, School of Medicine, Sacramento, CA, USACorrespondence: Gary D Novack, PharmaLogic Development, Inc., 17 Bridgegate Drive, San Rafael, CA, 94903, USA, Tel +1 415 472-2181, Email [email protected]: We wanted to develop a new topical ocular anesthetic with good bioavailability in anterior segment tissues. Given concerns about contamination and sterility in multi-dose products, we selected a unit-dose, nonpreserved presentation of AG-920 (articaine ophthalmic solution) in blow-fill-seal containers (similar to currently marketed pharmacological therapies for dry eye disease).Methods: Consistent with US Food and Drug Administration guidance, two pivotal, Phase 3, randomized, placebo-controlled, double-masked, parallel design studies conducted at two US private practices in 240 healthy subjects. A single dose of AG-920 or identical looking placebo into one (study) eye (2 drops 30 s apart). Subjects underwent a conjunctival pinch procedure and assessment of the pain associated with the pinch. The main outcome measure was the proportion of subjects with rating of “No pain at 5 minutes”.Results: AG-920 provided a rapid onset of local anesthesia (less than one minute) with clinically and statistically significantly greater effect in AG-920 (68% and 83%) than placebo (3% and 18% for Study 1 and Study 2, respectively, P< 0.0001). The most frequent adverse event was instillation site pain (27% vs 3%) followed by conjunctival hyperemia (probably related to the pinch, 9% vs 10%) in the AG-920 and placebo groups, respectively.Conclusion: AG-920 was found to be have a rapid onset and useful duration of local anesthesia with no major safety issues, and may be useful for the eye-care professional. Registered with clinicaltrials.gov as NCT04513652 and NCT04829344.Keywords: local anesthesia, articaine, controlled tria
Weather–Mortality Association in Patients With Chronic Heart Failure: 5-year Longitudinal Study Across 4 Different Regions in Israel
No full textNew kids on the European block: Finnish and Swedish adaptation to the European Union?
No full textThis thesis examines Finnish and Swedish membership in the European Union since the two Nordic countries joined (along with Austria) in January 1995 to become "new kids on the European block." The author compares the strategies that national decision-makers have pursued in EU policy-making to assess the nature and extent of their adaptation to the European Union. This analysis relies on case studies of three policy areas: 1) Economic and Monetary Union (with a focus on the decision on whether or not to adopt the Euro in the first wave); 2) relations with non-EU neighbours in Northern Europe (with particular attention given to EU enlargement and the Northern Dimension Initiative); and 3) public access to documents. Although the thesis concentrates primarily on empirical analysis, it also provides a theoretical critique. The author argues that differences in the historical backgrounds, institutions, cultures, and identities of Finland and Sweden have led to differences in their approaches to the EU. The thesis presents a challenge to existing theoretical frameworks that leave little or no room for the four factors that are emphasised here, with particular attention given to the approaches of Andrew Moravcsik (1998) and Christine Ingebritsen (1998)
New kids on the European block: Finnish and Swedish adaptation to the European Union?
Get PDFThis thesis examines Finnish and Swedish membership in the European Union since the two Nordic countries joined (along with Austria) in January 1995 to become "new kids on the European block." The author compares the strategies that national decision-makers have pursued in EU policy-making to assess the nature and extent of their adaptation to the European Union. This analysis relies on case studies of three policy areas: 1) Economic and Monetary Union (with a focus on the decision on whether or not to adopt the Euro in the first wave); 2) relations with non-EU neighbours in Northern Europe (with particular attention given to EU enlargement and the Northern Dimension Initiative); and 3) public access to documents. Although the thesis concentrates primarily on empirical analysis, it also provides a theoretical critique. The author argues that differences in the historical backgrounds, institutions, cultures, and identities of Finland and Sweden have led to differences in their approaches to the EU. The thesis presents a challenge to existing theoretical frameworks that leave little or no room for the four factors that are emphasised here, with particular attention given to the approaches of Andrew Moravcsik (1998) and Christine Ingebritsen (1998)
Ambient Air Pollution, Weather and Daily Emergency Department Visits for Headache in Southern Israel
No full textDo air pollution and neighborhood greenness exposures improve the predicted cardiovascular risk?
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