1,720,972 research outputs found
Development of transdermal delivery systems for innovative clinical applications of cannabinoids
Full text linkThe use of cannabis for medicinal purposes is deeply rooted in history, dating back to ancient times. While there has been a strong push for legalizing medicinal cannabis and research, conclusive evidence regarding the short- and long-term health effects (harms and benefits) of cannabis use remains elusive because of a high variability when cannabinoids are administered orally or by inhalation. Transdermal delivery of cannabinoids could allow a constant, defined release of these active ingredients. The main goal of this project was to develop innovative pharmaceutical forms in order to ensure a constant release of cannabinoids to the patient. By using a synthesized model molecule, desoxy-CBD, innovative vesicular systems were developed, characterized, and compared with vesicles loaded with cannabis extracts
Sintesi e purificazione dei precursori di desossiCBD per formulazioni innovative per cannabinoidi
No full textSynthesis and purification of desoxy-CBD precursors for innovative pain therapy formulations
No full textCharacterization of Structure-Surface Correlations in Ointments Using Surface Tensiometry within the Concept of an Integrated Analytical Approach
Full text linkIn recent years, integrated data analysis has proven to be a valuable method for investigating complex systems, whether artificial or natural. The integrated analytical approach allows the simultaneous integration of data acquired from different analytical techniques employed for the same sample at the same time, leading to an expansion of the amount of information available. Surface tensiometry is a technique that was recently introduced in the Integrated Analytical Approach for investigating pharmaceutical dosage forms for topical application. Therefore, studies of rheological characterization, release, and skin permeation can be integrated with surface tensiometry measurements to develop chemical and rheological-surface correlation models, providing a new method for the quality control and process control of semisolid preparations. In this context, the aim of this research is to validate the utility of surface tensiometry measurements in the Integrated Analytical Approach and utilize these data to gain insights into the structure-surface correlation. The preparations chosen for this study were a PEG-gel, a lipogel, and an O/W cream containing carnitine as a model drug. The formulations were characterized using rheological measurements and evaluated for their carnitine release performance. Furthermore, surface tensiometry measurements were performed to rapidly and noninvasively assess the influence of carnitine on the surface properties of the semisolid preparations investigated. Our work demonstrated a close correlation between surface energy and structural data, showing the importance of surface tensiometry contribution in the noninvasive and rapid evaluation of the presence of carnitine in semisolid formulations
Necessità di associare il giudizio clinico alla classificazione NEWS per migliorare la stratificazione del rischio di deterioramento nei pazienti di Medicina Interna con sindrome coronarica acuta non complicata
No full textSviluppi del progetto Isolpharm: deposizione e recupero di Iodio da un facio di ioni accelerati con tecnologia Isol per radiofarmaci innovativi
No full textL’APPROCCIO TENSIOMETRICO NEL CAMPO DELLA TECNOLOGIA FARMACEUTICA: ESPERIENZE, APPLICAZIONI E PROSPETTIVE
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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