1,720,958 research outputs found
PIAL ARTERIOLAR VASOMOTION CHANGES DURING CORTICAL ACTIVATION IN RATS
No full textThe oscillatory pattern of pial arterioles, i.e. vasomotion, has been described since early 1980s, but the impact of neural activation on such oscillations has never been formally examined. Sciatic nerve stimulation, a well characterized model for studying neurovascular coupling (NVC), leads to a neural activity-related increase of pial arteriolar diameter in the contralateral hindlimb somatosensory cortex. Exploiting such an experimental model, the aim of the present study was to explore vasomotion and its changes during NVC with a novel analytical approach. Indeed, to characterize oscillations, we evaluated the total spectral power in the range 0.02-2.00 Hz and subdivided this frequency interval into seven 50% overlapping frequency bands. Results indicated that only arterioles overlying the stimulated hindlimb cortex showed a significant increase of total power, unlike arterioles overlaying the whisker barrel cortex, used as control for the vascular response specificity. The total power increase was sustained mainly by marked increments in the low frequency range, with two peaks at 0.03 and 0.08 Hz, and by a wide increase in the high frequency range (0.60-2.00 Hz) in the averaged spectrum. These activity-related spectral changes suggest: (i) that it is possible to assess the vascular responses by using total power; (ii) the existence of at least three distinct mechanisms involved in the control of NVC, two with a feedback frequency loop in the low frequency range and another one in the high range; (iii) a potential involvement of vasomotion in NVC. Moreover, these findings highlight the oscillatory nature of the mechanisms controlling NVC
Effects of melatonin and luzindole during ischemia reperfusion injury in rat pial microcirculation
No full textThis study aimed to investigate the role of melatonin [MT] againstbrain ischemia-reperfusion injury after MT receptor inhibition byluzindole [LZ]. The pial microcirculation of male Wistar rats wasobserved by fluorescence microscopy through a cranial window, using fluorescent dextran [70 K] as a tracer. Vessel diameter, permeability increase [PI], leukocytes adhering to venular walls [LA], capillary red blood cell velocity [CVRBC] and perfused capillary length [PCL] were determined by computerized methods. MT [0.5-1-2 mg/Kg body wt.,i.v.] was infused 10 min before ischemia, induced by bilateral occlusion of common carotid arteries for 30 min, and at the beginning of reperfusion lasting 60 min. In the control group, ischemia caused constriction of arterioles, while reperfusion induced constriction, dilation andconstriction within 40 min. At the end of reperfusion vessel permeability and adhering leukocytes increased; CVRBC and PCL were reduced. MT dose-dependently decreased arteriolar constriction during ischemia and reperfusion. At 40 min of reperfusion MT highest dosage caused dilation of all arterioles. PI and LA were reduced, CVRBC and PCL increased compared to control [p<0.01]. LZ [2 mg/Kg body wt.] prior to MT [2mg/Kg body wt.] prevented arteriolar dilation observed at 40 min ofreperfusion, but did not influence the effects of MT against interstitial edema and leukocyte adhesion. CVRBC and PCL did not differ from baseline. In conclusion, MT appears to cause dilatation of pial arterioles through MT1 and MT2 receptors and protection against blood brain barrier disruption likely acting as a free radical scavenger
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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