64 research outputs found
Bone metastases from primary cardiac sarcoma: case report
No full textTumor spread from primary cardiac sarcoma to the bone is very rare and has a poor prognosis. Only six cases have been reported in the literature. We present a 32-year-old female patient with bone metastases from primary cardiac sarcoma
Citizenship in the Arab world: kin, religion and nation-state
No full textThe book is the fruit of five years of on-site research on citizenship in the Arab world. It takes a broader legal perspective to the multifaceted reality of nationality and citizenship. The methodology employed builds on the interdisciplinary approach of comparative legal studies, and brings in theories, concepts and insights from anthropology, political science, Arab and Islamic studies, linguistics and sociology. The work relies on a broad range of Western and Arab references, and all sources and documents were directly accessed in their original languages; this is particularly relevant for Arab legislation (all in-text reference has been translated by the author, and the original has been inserted using scientific transliteration).Gianluca P. Parolin deed vijf jaar lang onderzoek naar burgerschap in het Midden-Oosten. In dit boek plaatst de auteur dit begrip in een breder juridisch perspectief naar de maatstaven van de complexe realiteit van nationaliteit en burgerschap. Wetten op het gebied van nationaliteit zijn vaak gebaseerd op staten en worden als volledig soeverein beschouwd. Maar deze wetten zijn alleen effectief als rekening gehouden wordt met de culturele en juridische achtergrond van de burgers waarop ze van toepassing zijn
Application of the Lausanne Trilogue Play Procedure to Families with Adolescent Sons: A Preliminary Study. L'Osservazione delle interazioni familiari in adolescenza: Studio preliminare sull'applicazione della procedura del Lausanne Trilogue Play.
No full textThe study focuses on the application of the Lausanne Trilogue Play (LTP) procedure for the observation of triad interaction among mother-father-child in adolescence and it intends to provide a preliminary contribution to the validation of the coding system of the procedure (FAAS 6.3). For this purpose, the LT P procedure was administered to 3 groups of families (N = 58): a group of families referred to Neuropsychiatry Unit (SC IAF), a group of families with a child admitted to residential treatment for Substance Use Disorders and a comparison group. Results indicated good levels of inter-rater reliability and clinical validity for the LT P procedure and the coding system proposed by the author
Clinical results of randomized trials and 'real-world' data exploring the impact of Bevacizumab for breast cancer: opportunities for clinical practice and perspectives for research
No full textAngiogenesis plays a fundamental role in breast cancer (BC) growth, progression and metastatic spread. After the promising introduction of bevacizumab for the treatment of advanced BC, the initial enthusiasm decreased when the FDA withdrew its approval in 2011. Nevertheless, several clinical studies exploring the role of bevacizumab have been subsequently published. Areas covered: The aim of this study is to review the available clinical trials exploring the potential effectiveness of bevacizumab in BC, regardless of the disease setting. Expert opinion: Even if the evidence suggests that bevacizumab must be ruled out from the HER2-positive and adjuvant setting, bevacizumab's benefit remains uncertain in the neoadjuvant setting and in the advanced treatment of HER2-negative patients. In the first setting, the addition of bevacizumab to chemotherapy increased the pathological complete response (pCR) rate in most clinical trials. However, the current absence of evidence that pCR is a trial-level surrogate for survival requires waiting for long-term results. In the advanced setting, all trials showed a benefit in progression-free survival, but not in overall survival, highlighting an increase of adverse events. The lack of predictors of response represents the main unmet need in which future clinical research will undoubtedly invest
Value-Impact Analysis (VIA) templates
No full textValue-Impact Analysis (VIA) is a process and a toolkit to enable a guided assessment of the environmental sustainability of new technologies and concepts in manufacturing companies.This file contains the templates for the activities in VIA.For more information on VIA and applying the templates, please contact the author.</p
Hydatidiform Mole with Coexisting Normal Pregnancy: A Systematic Review and Individual Participant Data Meta-Analysis
No full textBackground and Objectives: This study aimed to evaluate obstetric, neonatal, and oncologic outcomes of pregnancies complicated by a hydatidiform mole coexisting with a live fetus (HMCF) carried beyond viability, and to assess the impact of delivery mode on outcomes. Materials and Methods: A systematic review and individual participant data meta-analysis included HMCF cases progressing beyond 23 weeks. Obstetric and neonatal outcomes, delivery patterns, and oncologic risks were analyzed. Results: Among 118 pregnancies complicated by HMFC (124 newborns), most were complete moles (87%). Median delivery occurred at 31.6 weeks, with over half before 32 weeks. Common complications included vaginal bleeding (59%), preeclampsia (30%), and hyperthyroidism (18%). Cesarean delivery was performed in 79% of cases, often for mole-related factors, but was not associated with reduced maternal or oncologic risk. Neonatal deaths occurred exclusively in infants delivered ≤32 weeks, highlighting extreme prematurity as the key determinant of survival. Severe preeclampsia was strongly linked to earlier delivery. Conclusions: With close monitoring, continuation of HMCF pregnancies is possible. Neonatal mortality is mainly driven by prematurity, which appears to be an indirect consequence of HMFC through the development of mola-associated complications. Cesarean section does not appear to improve maternal and oncologic outcomes. Vaginal delivery can be considered when no standard contraindications exist
Evidence-based tailored nutrition educational intervention improves adherence to dietary guidelines, anthropometric measures and serum metabolic biomarkers in early-stage breast cancer patients: A prospective interventional study
No full textPurpose: The impact of the adherence to dietary guidelines of early-stage breast cancer (EBC) patients on body composition changes during treatment is not entirely defined. This study aimed to evaluate the role of an evidence-based nutrition educational intervention, according to adherence to dietary guidelines, in EBC patients. Methods: This prospective study included EBC patients, candidates for neoadjuvant/adjuvant therapy. Patients received an evidence-based tailored nutrition educational intervention. The adherence to dietary guidelines, anthropometric and dietary assessments, and blood glucose and lipid profile tests were evaluated at baseline and after a 12-months nutritional intervention. Results: Two hundred and forty-three patients were enrolled. At baseline, 38.3% and 23.9% of patients were overweight and obese, weight gain ≥5% (compared to 6-months before enrollment) and central obesity were observed in 47.3% and 52.7% of patients, respectively. Adherence to dietary guidelines was low (median Med-Diet score: 6 [IQR 4–8]). After the nutritional intervention (median follow-up: 22 months [range 12–45]), adherence to dietary guidelines significantly increased (median Med-Diet score: 12 [IQR 8–13]), p < 0.0001). High adherence to dietary guidelines (defines as Med-Diet score ≥10) significantly correlated with: 1) overall weight loss ≥5% (21.8% vs. 2.5%, p = 0.003); 2) median BMI drop (from 25.6 kg/m2 to 24.4 kg/m2, p = 0.003); 3) lower prevalence of central obesity (38.2% vs. 7.2%, p = 0.01); 4) improvement in blood glucose levels and lipid profile. Conclusion: This study suggests that an evidence-based tailored nutrition educational intervention during treatment for EBC significantly increases overall adherence to dietary guidelines, and it improves both anthropometric measures and serum metabolic biomarkers in patients with high adherence
Optimizing CDK4/6 inhibitors in advanced HR+/HER2- breast cancer: A personalized approach
No full textCyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy (ET) are now a backbone of treatment for hormone receptor-positive/human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer. CDK4/6i plus ET is more effective than ET alone in this setting; however, the risk of grade 3-4 adverse events also increases. Approved agents in this class have similar efficacies, but important differences due to their structural and pharmacological properties. We review biomarkers and discuss determinants to inform a rational approach to therapy choice when selecting the most appropriate ET and CDK4/6i partners. We also identify subgroups that may benefit from specific ET-CDK4/6i combinations and discuss strategies to overcome resistance. This personalized approach aims to minimize treatment-related toxicities that may affect patient QoL and compliance, and ultimately therapy efficacy
Citizenship in the Arab World
No full textThe book is the fruit of five years of on-site research on citizenship in the Arab world. It takes a broader legal perspective to the multifaceted reality of nationality and citizenship. The methodology employed builds on the interdisciplinary approach of comparative legal studies, and brings in theories, concepts and insights from anthropology, political science, Arab and Islamic studies, linguistics and sociology. The work relies on a broad range of Western and Arab references, and all sources and documents were directly accessed in their original languages; this is particularly relevant for Arab legislation (all in-text reference has been translated by the author, and the original has been inserted using scientific transliteration)
The history of the Romano famili and "Angelo, tyran de Padoue" by Victor Hugo.
No full textreservedVictor Hugo, nel dramma Angelo, tyran de Padue, ricama tre diverse epoche storiche: i primi decenni dell’Ottocento, a lui contemporanei; la metà del Cinquecento, prescelta per lo svolgimento dell’azione drammatica; il tardo Medioevo evinto dai personaggi principali che compongono il racconto. Tuttavia, l’interesse storico e prettamente romantico verso il periodo medievale assume in quest’opera una rilevanza primaria. Tra le tante casate del nord Italia nominate dall’autore nell’opera, una su tutte sembra essere davvero simbolica. Particolarmente interessante è stato comprendere come la storia della famiglia da Romano costituisca il fulcro della costruzione drammaturgica. Ezzelino III e Cunizza da Romano sono elevati a emblema della poetica romantica e divengono funzionali al messaggio politico e sociale dell’autore.Victor Hugo, in his play Angelo, tyran de Padue, embroiders three different historical epochs: the first decades of the 19th century, contemporary with him; the middle of the 16th century, chosen for the unfolding of the dramatic action; and the late Middle Ages evoked by the main characters in the story. However, the historical and purely romantic interest in the medieval period takes on primary importance in this work. Of the many northern Italian lineages named by the author in the work, one in particular seems to be truly symbolic. It was particularly interesting to understand how the history of the da Romano family forms the core of the dramaturgical construction. Ezzelino III and Cunizza da Romano are elevated to emblems of romantic poetics and become functional to the author's political and social message
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