1,721,202 research outputs found
Cerebrovascular assessment for the risk prediction of Alzheimer’s disease.
No full textCerebrovascular Assessment for the Risk Prediction of Alzheimer's Disease.
Silvestrini M, Viticchi G, Altamura C, Luzzi S, Balucani C, Vernieri F.
Neurological Clinic, Marche Polytechnic University, Ancona, Italy.
Increasing evidence is emerging that vascular disease and its risk factors play a
role in the development of Alzheimer's disease (AD) and affect the probability of
an adverse outcome. The aims of this review are to explore the relationship
between vascular risk factors and AD and to discuss the potential use of vascular
markers in the clinical approach to cognitive impairment. Moreover, we present
evidence about the potential use of ultrasonographic and neuroradiologic markers
of cognitive impairment in order to establish possible treatment strategies in
subjects with a clinical profile at risk of developing AD
Outcome of carotid artery occlusion is predicted by cerebrovascular reactivity
No full textBACKGROUND AND PURPOSE: The purpose of this study was to investigate the
possibility of obtaining prognostic indications in patients with internal carotid
occlusion on the basis of intracranial hemodynamic status, presence of previous
symptoms of cerebrovascular failure, and baseline characteristics.
METHODS: Cerebral hemodynamics were studied with transcranial Doppler
ultrasonography. Cerebrovascular reactivity to apnea was calculated by means of
the breath-holding index (BHI) in the middle cerebral arteries. Sixty-five
patients with internal carotid artery occlusion were followed-up prospectively
(median, 24 months), 23 patients were asymptomatic and 42 symptomatic (20 with
transient ischemic attack and 22 with stroke).
RESULTS: During the follow-up period, 11 symptomatic patients and 1 asymptomatic
patient had another ischemic event ipsilateral to carotid occlusion. Among
factors considered, only lower BHI values in the middle cerebral arteries
ipsilateral to carotid occlusion and older age were significantly associated with
the risk of developing symptoms (P=0.002 and P=0.003, respectively; Cox
regression multivariate analysis). Based on our data, a cut point of the BHI
value for distinguishing between pathological and normal cerebrovascular
reactivity was determined to be 0.69. All patients except one, who developed TIA
or stroke during the follow-up period, had BHI values ipsilateral to carotid
occlusion of <0.69.
CONCLUSIONS: These data suggest that impaired cerebrovascular reactivity is
predictive for cerebral ischemic events in patients with carotid occlusion
Impaired cerebral vasoreactivity and risk of stroke in patients with asymptomatic carotid stenosis. Patterns of cerebrovascular reactivity in patients with carotid occlusion and severe contralateral stenosis
No full text
Cerebrovascular reactivity in patients with bilateral carotid occlusive disease. carotid occlusion and severe contralateral stenosis
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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