1,792 research outputs found
Supplementary Information for "Top-down proteomics of mouse islets with beta cell CPE deletion reveals molecular details in prohormone processing"; Figures S1-S9, Tables S1-S4
No full textSupplementary information (figures and tables) for "Top-down proteomics of mouse islets with beta cell CPE deletion reveals molecular details in prohormone processing" by James M. Fulcher, Adam C. Swensen, Yi-Chun Chen, C. Bruce Verchere, Vladislav A. Petyuk, Wei-Jun Qian</p
History sketch 157th Engineer (C) Bn.
No full textThis is a historical description of the 157th Engineer (C) Battalion written from memory by author. Notes are not attached as described on last page of document
Learning Phonological Grammars for Output-Driven Maps
No full textThe challenge of simultaneously learning a lexicon of underlying forms and a constraint ranking has been addressed by several scholars in recent work (Apoussidou 2007, Jarosz 2006, Merchant 2008, Tesar 2006). In particular, the proposal of Merchant, the Contrast Pair and Ranking information algorithm (CPR), avoids having to explicitly enumerate all possible underlying forms for each morpheme (in contrast to Apoussidou and Jarosz), and also avoids having to explicitly enumerate all possible constraint rankings (in contrast to Jarosz).
While CPR avoids those computational traps, there are still some components of CPR (and of the related work by Tesar) that pose computational difficulties. (1) The focus of CPR on lexical hypotheses for only a pair of related words at a time (a contrast pair) is a vast improvement over simultaneous consideration of all possible lexica, but the space of lexical hypotheses for a single contrast pair still grows exponentially in the number of unset underlying features for the morphemes involved in the pair. (2) The technique of initial lexicon construction, setting in advance features that do not alternate, can restrict further the number of lexical hypotheses that need to be considered, but at the cost of requiring that the learner have a complete paradigm of surface form data before learning of underlying forms can begin. (3) The extraction of ranking information performed by CPR is able to obtain ranking information from contrast pairs for which complete underlying forms have not yet been determined, but also faces exponential computational complexity, due in part to the fact that the procedure is separately computing the ranking implications of each lexical hypothesis in the (exponentially growing) set of possible hypotheses for the contrast pair.
The current paper demonstrates that each of these computational concerns can be significantly improved upon by taking the structure of grammars into greater consideration. The key grammatical structure lies in Tesar's proposal of output-driven map (Tesar 2008). Intuitively, an output-driven map is a phonological map in which all disparities introduced between the input and the output are motivated by conditions on the output. This notion is formalized by the requirement that any grammatical input-output mapping A->C entails the grammaticality of B->C whenever B has 'greater similarity' to C than A does (A->C has every input-output disparity that B->C does, but B->C may lack some disparities of A->C). An output-driven map is necessarily a restricted identity map (Prince and Tesar 2004), meaning that every grammatical form maps to itself, a property assumed to hold of grammars in much learnability work, including that of Merchant. Output-driven maps can be viewed as a strengthened version of restricted identity maps.
The structure of output-driven maps can be exploited in learning via the contrapositive: B~->C entails A~->C. Given a grammatical output C, it is a given that C->C (restricted identity map property). Suppose B has one disparity with C (e.g., they differ in the value of one feature on one segment). If the learner possesses sufficient information to determine that B cannot map to C, then the learner need not bother checking to see if A maps to C; because the map is output-driven, any input which has, relative to C, all of the disparities of B plus additional ones cannot be grammatical. All lexical hypotheses which include all of the disparities of B->C may be dismissed without evaluation. Instead of needing to evaluate all combinations of possible values for all unset features of a word (exponential in the number of unset features), the learner can obtain the same information while only evaluating a single unset feature at a time (linear in the number of unset features), having the other unset features match (temporarily) the values of their output correspondents, addressing concern (1). If a word has eight unset binary features, this means evaluating 8 lexical hypotheses instead of 256. Even greater benefit is realized when obtaining ranking information from forms with unset features, addressing concern (3).
The speed-up realized by exploiting the structure of output-driven maps is significant enough that initial lexicon construction is no longer needed. This frees the learner from needing an entire paradigm before learning commences; the learner can begin learning about underlying forms from even a single datum, addressing concern (2). This algorithm has the notable property that features of underlying forms which cannot be shown to require a particular value remain unset; non-contrastive features are never set, without any need for the learner to separately construct an 'inventory of contrastive features'.The definitive version of this paper is published in NELS 39: Proceedings of the 39th Annual Meeting of the North East Linguistic Society (2011
The activity and biosynthesis of beta-cell peptide hormones : implications in diabetes, obesity, and pancreatic cancer
No full textType 1 and type 2 diabetes are characterized by hyperglycemia and loss of beta-cell mass, function, and peptide hormones. Beyond hyperglycemia, diabetes is also associated with obesity and increased risk of cancer, particularly pancreatic cancer. Islet amyloid polypeptide (IAPP) is the second most abundant beta-cell hormone, co-secreted with insulin, and reduced in diabetes. Paracrine actions of endogenous IAPP have been proposed in glycemic regulation and tumour growth suppression, but remain incompletely understood. To further characterize the effects of IAPP loss, we used an IAPP-knockout mouse fed a high-fat or control diet and assessed glycemia and adiposity. We also generated a genetic mouse model of pancreatic ductal adenocarcinoma in IAPP-knockout mice to investigate IAPP loss as a potential mechanism for the association of diabetes and pancreatic cancer. Trends in IAPP-knockout mice suggest elevated adiposity and glycemia in the absence of IAPP. We observed no effect of IAPP on pancreatic ductal adenocarcinoma survival in mice, or cancer cell proliferation, death, or glycolysis.
A reduction in the processing efficiency of beta-cell peptide prohormones is also observed in diabetes. Pcsk1 and Pcsk2 are the two major prohormone endoproteases within insulin granules, and are responsible for multiple steps in the proIAPP and proinsulin processing pathways. To determine whether impaired processing functions as a biomarker or driver of beta-cell dysfunction, we generated mouse models of beta-cell specific (Ins1cre-driven) Pcsk1 and Pcsk2 deficiency using Cre-lox recombination. Loss of Pcsk1 in beta cells caused severe proinsulin processing impairments and increased diabetes susceptibility in male mice, while female mice remained euglycemic. In contrast, male and female beta-cell Pcsk2-deficient mice were euglycemic with minimally impaired proinsulin processing, but severely impaired proIAPP processing. Deletion of both Pcsk1 and Pcsk2 in beta cells blocked proinsulin processing, drove hyperglycemia, increased beta-cell glucose responsiveness and mass, and reduced beta-cell maturity and proliferative capacity. In a mouse model expressing amyloidogenic human IAPP in beta cells, Pcsk1 deficiency significantly increased amyloid deposition. Collectively, these findings show that loss of beta-cell prohormone processing alters beta-cell function and drives hyperglycemia, and that endogenous IAPP does not act as a pancreatic tumour suppressor but may alter glycemia and adiposity.Medicine, Faculty ofPathology and Laboratory Medicine, Department ofGraduat
Islet macrophages response to beta cell stresses
No full textThe full abstract for this thesis is available in the body of the thesis, and will be available when the embargo expires.Medicine, Faculty ofPathology and Laboratory Medicine, Department ofGraduat
Bruce Mayne Stars
No full textPhotograph used for a story in the Daily Oklahoman newspaper. Caption: "Gaslight Dinner Theatre's version of "The Impossible Years" arrives from Raleigh, N. C. Starring is Bruce Mayne, an actor with 125 productions to his credit. In this production coming to OKC, Mayne plays Dr. Kingsley, author of a best-selling book, and busy preparing another volume, based on a study of teenage sexual behavior.
Editorial for progressive education: Antecedents of educating for democracy
No full textJournal Articl
LIQUIDITY AND VALUATION IN EAST AFRICAN SECURITIES MARKETS
No full textThis study estimates liquidity premiums using the recently developed Liu measure within a multifactor capital asset pricing model including size premiums and a time-varying parameter model for the East African emerging markets of Uganda, Tanzania and Kenya together with London and South Africa. The evidence suggests that while size and liquidity effects are significant in the smaller emerging markets of Uganda and Kenya, they are less important in explaining returns in South Africa and London. Costs of equity are highest in Uganda followed by Kenya, with industrial and consumer non-cyclical sectors being lowest, and then South Africa and London. Copyright (c) 2009 The Author. Journal compilation (c) 2009 Economic Society of South Africa.
Mixed Bruce-Roberts numbers
No full text[EN] We extend the notions of mu*- sequences and Tjurina numbers of functions to the framework of Bruce-Roberts numbers, that is, to pairs formed by the germ at 0 of a complex analytic variety X. Cn and a finitely R( X)-determined analytic function germ f : (Cn, 0). (C, 0). We analyze some fundamental properties of these numbers.Part of this work was developed during the stay of the first author at the Departamento de Matematica of ICMC, Sao Carlos, Universidade de Sao Paulo (Brazil), in February and July 2018. The first author wishes to thank this institution for their hospitality and working conditions and to FAPESP for financial support. The first author was partially supported by MICINN Grant PGC2018-094889-B-I00 and FAPESP Grant 2014/00304-2. The second author was partially supported by CNPq Grant 306306/2015-8 and FAPESP Grant 2014/00304-2.Bivià-Ausina, C.; Ruas, M. (2020). Mixed Bruce-Roberts numbers. Proceedings of the Edinburgh Mathematical Society. 63(2):456-474. https://doi.org/10.1017/S0013091519000543S456474632Damon, J. (1996). Higher multiplicities and almost free divisors and complete intersections. Memoirs of the American Mathematical Society, 123(589), 0-0. doi:10.1090/memo/0589Wahl, J. M. (1983). Derivations, automorphisms and deformations of quasihomogeneous singularities. Proceedings of Symposia in Pure Mathematics, 613-624. doi:10.1090/pspum/040.2/713285De Goes Grulha, N. (2008). THE EULER OBSTRUCTION AND BRUCE-ROBERTS’ MILNOR NUMBER. The Quarterly Journal of Mathematics, 60(3), 291-302. doi:10.1093/qmath/han011Greuel, G.-M. (1975). Der Gau�-Manin-Zusammenhang isolierter Singularit�ten von vollst�ndigen Durchschnitten. Mathematische Annalen, 214(3), 235-266. doi:10.1007/bf01352108Gaffney, T. (1996). Multiplicities and equisingularity of ICIS germs. Inventiones Mathematicae, 123(1), 209-220. doi:10.1007/bf01232372Damon, J. (2002). On the freeness of equisingular deformations of plane curve singularities. Topology and its Applications, 118(1-2), 31-43. doi:10.1016/s0166-8641(01)00040-2Bruce, J. W., & Roberts, R. M. (1988). Critical points of functions on analytic varieties. Topology, 27(1), 57-90. doi:10.1016/0040-9383(88)90007-9Decker, W. , Greuel, G.-M. , Pfister, G. and Schönemann, H. , Singular 4-0-2. A computer algebra system for polynomial computations. Available at http://www.singular.uni-kl.de (2015).Looijenga, E. J. N. (1984). Isolated Singular Points on Complete Intersections. doi:10.1017/cbo9780511662720AHMED, I., RUAS, M. A. S., & TOMAZELLA, J. N. (2013). Invariants of topological relative right equivalences. Mathematical Proceedings of the Cambridge Philosophical Society, 155(2), 307-315. doi:10.1017/s0305004113000297Aleksandrov, A. G. (1986). COHOMOLOGY OF A QUASIHOMOGENEOUS COMPLETE INTERSECTION. Mathematics of the USSR-Izvestiya, 26(3), 437-477. doi:10.1070/im1986v026n03abeh001155Briançon, J., & Maynadier-Gervais, H. (2002). Sur le nombre de Milnor d’une singularité semi-quasi-homogène. Comptes Rendus Mathematique, 334(4), 317-320. doi:10.1016/s1631-073x(02)02256-2Giusti, M., & Henry, J.-P.-G. (1980). Minorations de nombres de Milnor. Bulletin de la Société mathématique de France, 79, 17-45. doi:10.24033/bsmf.1907Hauser, H., & Müller, G. (1993). Affine varieties and lie algebras of vector fields. Manuscripta Mathematica, 80(1), 309-337. doi:10.1007/bf03026556Liu, Y. (2018). Milnor and Tjurina numbers for a hypersurface germ with isolated singularity. Comptes Rendus Mathematique, 356(9), 963-966. doi:10.1016/j.crma.2018.07.004Nuno-Ballesteros, J. J., Orefice, B., & Tomazella, J. N. (2011). THE BRUCE-ROBERTS NUMBER OF A FUNCTION ON A WEIGHTED HOMOGENEOUS HYPERSURFACE. The Quarterly Journal of Mathematics, 64(1), 269-280. doi:10.1093/qmath/har032Ohmoto, T., Suwa, T., & Yokura, S. (1997). A remark on the Chern classes of local complete intersections. Proceedings of the Japan Academy, Series A, Mathematical Sciences, 73(5), 93-95. doi:10.3792/pjaa.73.93Lê Tráng, D. (1974). Calculation of Milnor number of isolated singularity of complete intersection. Functional Analysis and Its Applications, 8(2), 127-131. doi:10.1007/bf0107859
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