1,720,996 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
PK/PD EVALUATION OF PARECOXIB AND ITS ACTIVE METABOLITE VALDECOXIB IN CATS.
No full textParecoxib (PX) is a injective pro-drug of Valdecoxib (VX), known to be a selective cyclo-oxygenase-2 (COX-2)
inhibitor. The aim of the present study was to evaluate pharmacokinetics and pharmacodynamics in
vitro/ex vivo cyclooxygenase selectivity of PX and VX in cats.
In vitro evaluation of effects of PX and VX was performed using blood collected from 6 adult male cats
(Ethic committee's protocol number 2473 - University of Pisa) in sodium citrate and anticoagulant free
tubes for TXB2 (marker for COX-1 isoform) and PgE2 (marker for COX-2 isoform) measurements,
respectively. For COX-1 evaluation, blood aliquots were mixed with dymethil sulfoxide (DMSO) containing
VX or PX (0.0508-1,000 μM). Blood aliquots with only DMSO were used as controls. After incubation and
centrifugation, supernatants were analyzed using a commercial TXB2 ELISA kit. Samples for COX-2
evaluation were incubated with VX or PX and with 5μl of lipopolysaccaride (LPS) solution to stimulate PgE2
synthesis. Supernatant was mixed with methanol (1:5) to allow protein precipitation. Supernatants were
analyzed using a commercial PgE2 ELISA kit. In ex vivo study, the same method used in in vitro study was
performed using samples collected by cats treated with 2.5 mg/kg of PX IM. For HPLC analysis, blood
samples were collected into lithium-heparinized tubes and plasma samples were prepared according to a
previous method (1) with some modifications. Pharmacokinetic analyses were described by a noncompartmental
model (WinNonLin 5.3, Parsight).
The IC50 values of VX for COX-2 and COX-1 were 0.45 and 38.6 μM, respectively. PX did not affect COX
enzymes. HPLC analysis showed that PX is rapidly converted to VX with a relatively short half-life of 0.4 h.
VX achieved peak plasma concentration (2.79 ± 1.59 μg/mL) at 7 h following PX injection. The mean
residence times for PX and VX were 0.43 ± 0.15 and 5.94 ± 0.88 h, respectively. The ex vivo study showed a
COX-2 inhibition rate of about 70% in samples taken at 1, 2, 4 and 10 h after injection of PX. COX-1
inhibition ranged from 0.7% to 9.7% compared to the control without any significant difference for 24 h
after PX administration.
Although PX has not been studied as extensively in veterinary medicine as it has been in humans, some
preliminary studies reported that this drug might also be effective and safe (2, 3) in animal species. Results
of the present study seem to encourage further experiments on feline species to investigate whether this
drug could be successfully used in feline medicine
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
George-Henri Soutou e la Dichiarazione federalista internazionale dei movimenti di resistenza
No full textDispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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