100,683 research outputs found
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Drug delivery from the oral cavity: focus on a novel mechatronic delivery device
No full textDental drug delivery systems have been used for a long time, in particular for the local therapy of diseases affecting the oral cavity. Research today concentrates on the design of formulations to increase their retention time. Even today, however, prosthetic devices incorporating drug delivery are rarely used. Mainly, they are focused on prophylaxis and the release of antibacterial agents. However, as buccal delivery, because of its undeniable advantages, has become popular for systemic drug delivery, and prolonged well-controlled release has been identified as beneficial, especially for chronic diseases, a new class of delivery systems is evolving: highly miniaturized computerized delivery systems, integrated into a dental appliance. Dental delivery systems today are used in two ways: the main application is the local treatment of diseases affecting the oral cavity itself like periodontitis or fungal infections. The second is for systemic drug delivery
FIGURE 1. Eospilopsyllus kobberti n. gen. and n in First extinct genus of a flea (Siphonaptera: Pulicidae) in Miocene amber from the Dominican Republic
No full textFIGURE 1. Eospilopsyllus kobberti n. gen. and n. sp., holotype specimen SMNS Do-5724. Reconstruction of the general habitus, excluding tarsi, in lateral view (scale bar: 0.5 mm). E = eye; CP = cervical link plate; Sp = spiracle; Se = Sensilium; T- VIII = tergite VIII; S-II, S-VII, S-VIII = sternite II, VII, and VIII; IX = genitalia, or abdominal segment IX.Published as part of Perrichot, Vincent, Beaucournu, Jean-Claude & Velten, Jürgen, 2012, First extinct genus of a flea (Siphonaptera: Pulicidae) in Miocene amber from the Dominican Republic, pp. 54-61 in Zootaxa 3438 on page 57, DOI: 10.5281/zenodo.20892
GRB Hubble diagram and constraints on a Lambda(t) CDM model
No full textVelten H, Montiel A, Carneiro S. GRB Hubble diagram and constraints on a Lambda(t) CDM model. Monthly Notices of The Royal Astronomical Society. 2013;431(4):3301-3306.In previous papers, a cosmological model with constant rate particle creation and vacuum term decaying linearly with the Hubble parameter was shown to lead to a good concordance when tested against precise observations: the position of the first peak in the spectrum of anisotropies of the cosmic microwave background (CMB), the Hubble diagram for Type Ia supernovae (SNe Ia), the distribution of large-scale structures and the distance to the baryonic acoustic oscillations (BAO). That model has the same number of parameters as the spatially flat standard model and seems to alleviate some observational/theoretical tensions appearing in the latter. In this paper, we complement those tests with 109 gamma-ray bursts (GRBs), 59 of them with redshifts above z = 1.4, which permits to extend the Hubble diagram to redshifts up to z approximate to 8. For the calibration of the 50 GRBs with z < 1.4, we use the 288 supernovae of the Sloan Digital Sky Survey project, calibrated with the MLCS2k2 fitter, less model-dependent than other samples like Union2. Our results show a good concordance with the previous tests and, again, less tensions between SNe Ia and GRB best fits as compared to the standard model
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Supplementary materials to: The cooperative revolution reaches clinical psychology and psychotherapy: An example from Germany
No full textSupplementary materials to: Margraf, J., Hoyer, J., Fydrich, T., In-Albon, T., Lincoln, T., Lutz, W., ... Velten, J. (2021). The cooperative revolution reaches clinical psychology and psychotherapy: An example from Germany. Clinical Psychology in Europe, 3(1), Article e4459. https://doi.org/10.32872/cpe.4459The Supplementary Materials include three tables listing the diagnoses of patients in Study 3
Pelevin’s Trinity in the novel “t”: author – protagonist – reader
No full textThe article attempts to interpret Pelevin's artistic strategy in the novel "T" by exploring its subject organization and addressing the key problems of the author, the protagonist, and the reader as they are seen by the researcher. The article analyzes the peculiarities of constructing the narrative reality in the novel "T", and goes on to discuss Pelevin's philosophic models of the development of the humankind, and the emergence of his new anthropology
Exploring women's perspectives on treating hypoactive sexual desire in the context of depressive disorders: A mixed qualitative methods study using online survey and focus group methodology
No full textHypoactive sexual desire is one of the most common sexual problems in women. According to the International Statistical Classification of Diseases and Related Health Problems (ICD-11), Hypoactive Sexual Desire Dysfunction (HSDD) is diagnosed when low sexual desire persists for at least several months and is associated with clinically significant distress. Problems with low desire are widespread in clinical populations of women with other mental disorders, with depression being one of the most common comorbidities (Basson & Gilks, 2018). HSDD negatively impacts various aspects of life, including reduced well-being, lower life satisfaction, mental health problems, and issues within partnerships (Biddle et al., 2009; Herder et al., 2023; Velten & Margraf, 2017). There are effective treatment options for female sexual dysfunction, including hypoactive sexual desire. However, women often avoid seeking professional help, in part due to the stigma surrounding their concerns and structural barriers within the healthcare system. The purpose of this study is to explore the unique perspective of women who experience HSDD while also being diagnosed with a depressive disorder. To this end, the lived experiences and treatment preferences of women will be explored using an online survey and focus group methodology.
Basson, R., & Gilks, T. (2018). Women’s sexual dysfunction associated with psychiatric disorders and their treatment. Women’s health, 14, 1745506518762664.
Biddle, A. K., West, S. L., D’Aloisio, A. A., Wheeler, S. B., Borisov, N. N., & Thorp, J. (2009). Hypoactive sexual desire disorder in postmenopausal women: Quality of life and health burden. Value in Health, 12(5), 763–772.
Herder, T., Spoelstra, S., Peters, A., & Knegtering, H. (2023). Sexual dysfunction related to psychiatric disorders: A systematic review. The Journal of Sexual Medicine.
Velten, J., & Margraf, J. (2017). Satisfaction guaranteed? How individual, partner, and relationship factors impact sexual satisfaction within partnerships. PloS one, 12(2), e0172855
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