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    Effects of aerobic exercise training in children after the Fontan operation

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    Am J Cardiol. 2005 Jan 1;95(1):150-2. Effects of aerobic exercise training in children after the Fontan operation. Opocher F, Varnier M, Sanders SP, Tosoni A, Zaccaria M, Stellin G, Milanesi O. Source Department of Pediatrics, Medical and Surgical Sciences, University of Padova, School of Medicine, Padova, Italy. Abstract It was demonstrated that patients who have undergone the Fontan operation can safely undertake exercise training and that this results in an improvement in aerobic capacity. These findings suggest that aerobic training could be useful in the long-term management of these patients to optimize their cardiovascular fitness for more active lives. PMID: 15619417 [PubMed - indexed for MEDLINE

    Varnier M. (éd.), Urbanisation et emploi, suburbains au travail autour de Lyon,

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    Chaline Claude. Varnier M. (éd.), Urbanisation et emploi, suburbains au travail autour de Lyon,. In: Annales de Géographie, t. 110, n°617, 2001. p. 107

    Varnier M. (éd.), Urbanisation et emploi, suburbains au travail autour de Lyon,

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    Chaline Claude. Varnier M. (éd.), Urbanisation et emploi, suburbains au travail autour de Lyon,. In: Annales de Géographie, t. 110, n°617, 2001. p. 107

    Do Kawasaki disease patients without coronary artery abnormalities need a long-term follow-up? A myocardial single-photon emission computed tomography pilot study

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    J Paediatr Child Health. 2009 Jul-Aug;45(7-8):419-24. Epub 2009 Jul 20. Do Kawasaki disease patients without coronary artery abnormalities need a long-term follow-up? A myocardial single-photon emission computed tomography pilot study. Zanon G, Zucchetta P, Varnier M, Vittadello F, Milanesi O, Zulian F. Source Rheumatology Unit, Department of Paediatrics, University of Padua, 35128 Padua, Italy. Abstract OBJECTIVE: To determine the frequency and risk factors for long-term myocardial perfusion scintigraphy abnormalities in patients with Kawasaki disease (KD). METHODS: A cohort of patients with KD at least 3 years after disease onset and with persistent coronary artery aneurysms (CAA) (group 1) or without CAA (group 2) underwent stress-rest myocardial single-photon emission computed tomography (SPECT). Clinical and laboratory parameters at disease onset were considered to assess their predictive value for the development of myocardial perfusion abnormalities. RESULTS: Forty patients, 20 in group 1 and 20 in group 2, entered the study. The two groups turned out to be comparable for demographic, clinical and laboratory characteristics. Five patients (12.5%), two in group 1 and three in group 2, had abnormal myocardial perfusion assessed by SPECT. Neither the presence of CAA nor the overall cardiac involvement at the disease onset significantly increased the risk for these abnormalities. CONCLUSION: Cardiac SPECT abnormalities are not unusual in KD and can be found in patients with or without CAA. If confirmed in a larger cohort of patients, these preliminary data indicate that careful long-term cardiac follow-up should be considered, regardless of the presence of CAA. PMID: 19712178 [PubMed - indexed for MEDLINE

    No effect of endurance exercise on serum bilirubin in healthy athletes and with congenital hyperbilirubinemia (Gilbert's syndrome).

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    Twenty male athletes, mean age 26 years, were studied by a work load test with cycle-ergometer, with increasing power output for 60 minutes until an intensity corresponding to 70% of the individual maximal heart rate was achieved. Ten of them had familial hyperbilirubinemia (Gilbert's syndrome) and ten had been considered as healthy controls. The diagnosis of Gilbert's syndrome was made using the following criteria: unconjugated hyperbilirubinemia, no systemic symptoms, no overt or clinically recognizable haemolysis, normal liver function tests. Blood levels of free fatty acids (FFA) showed a progressive significant increase after muscular exercise in both healthy and Gilbert's syndrome subjects (p < 0.001). The increase was more evident in controls compared to Gilbert's syndrome subjects (p < 0.05). Total and fractionated bilirubin showed no change in both groups. In conclusion, a competitive mechanism between bilirubin and FFA is probably responsible for the lower increase in plasma FFA in Gilbert's syndrome

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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