1,720,971 research outputs found
Mis de Winter niet!
No full textAbstract: Een patroon van het type de Winter, gekenmerkt door junctionele ST-segmentdepressies en grote symmetrische T-golven, is een zeldzame elektrocardiografische presentatie die voorkomt bij 1,6 % van alle voorwandinfarcten. Herkenning van dit patroon is essentieel opdat reperfusietherapie tijdig kan plaatsvinden
Microvascular dysfunction in adults with congenital heart disease and the effect of exercise training
No full textAbstract: Congenital heart diseases (CHDs) represent a complex and heterogeneous group of cardiac malformations associated with significant morbidity and mortality, affecting approximately 1% of live births worldwide. Advances in early management and surgical techniques have increased survival rates, leading to a continuously growing population of adults with CHD. However, these patients continue to face challenges, including reduced physical fitness, lower quality of life and poorer prognoses compared to healthy individuals of similar age. Consequently, the lifelong management of these patients has become increasingly important. Advancing therapeutic strategies, risk stratification and preventive measures requires a deeper understanding of the underlying pathophysiological mechanisms. This thesis investigates microvascular dysfunction (MVD) in adults with CHD and evaluates the effects of a 16-week home-based aerobic and strength exercise program. Our findings indicate substantial evidence for the presence of MVD in a significant proportion of adults with CHD. While existing literature suggests indications of both coronary and peripheral MVD in CHD, findings remain inconsistent. In our cohort of 55 adults with various CHD subtypes, a multimodal vascular assessment revealed a higher prevalence of peripheral MVD, increased large artery stiffness and elevated carotid arterial wall thickness compared to healthy reference populations. Notably, microvascular function in the finger correlated with inflammation, whereas no significant association was observed with superoxide anion radical levels, a measure of oxidative stress. Although prior research has reported elevated oxidative stress in CHD patients and suggested an association with disease severity, we were unable to confirm these findings in our study group. Vitamin D levels were also not significantly different in our heterogeneous CHD cohort compared to controls without cardiac disease. Nevertheless, vitamin D levels correlated with exercise capacity, even after adjusting for seasonal variation as a confounding factor. Further analysis revealed that right ventricular function, assessed using two-dimensional multi-plane echocardiography, was similarly correlated with exercise capacity in CHD. Additionally, our data demonstrated a significant association between arterial stiffness and exercise capacity, suggesting that reduced arterial stiffness is linked to higher peak oxygen consumption. Finally, our 16-week home-based aerobic and strength exercise program resulted in improved exercise capacity, muscle strength and quality of life, with no reported adverse events. These results suggest that the vasculature and right ventricular function should be a key area of focus in CHD management and that structured home-based exercise interventions can be both safe and effective in promoting better health outcomes for adults with CHD
Great debate : lipidlowering therapies should be guided by vascular imaging rather than by plasma biomarkers
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
- …
