1,721,037 research outputs found
Asymptomatic Chronic Elevation of Serum Pancreatic Enzymes: How to Deal with It?
No full textChronic asymptomatic pancreatic hyperenzymemia (CAPH) may be associated with different clinical circumstances, both pancreatic and extrapancreatic, ranging from a laboratory abnormality without clinical significance to the rare eventuality of an association with neoplastic lesions. This chapter summarizes the clinical circumstances that can initiate CAPH and provides an algorithm for clinical management. Up to 20% of patients with inflammatory bowel disease have been reported to present pancreatic hyperenzymemia without overt pancreatic disease. These enzyme elevations can be explained by subclinical extraintestinal involvement of the pancreas and by drug-induced hyperenzymemia, but some authors have proposed a more general mechanism based on increased reabsorption of amylase or lipase through the inflamed “leaky” gut. In 1978, different authors began reporting cohorts of patients with chronic increases in serum pancreatic enzymes. This elevation was frequently of nonpancreatic origin and that when isoenzyme profiling presumed a pancreatic origin, it often occurred in the absence of pancreatic abnormalities
Endoscopic ultrasound-guided gallbladder drainage after real-time assessment of cystic duct exclusion following biliary placement of an uncovered metal
No full textMorte improvvisa coronarica in soggetto con TBC polmonare miliarica e miocardite granulomatosa specifica. Correlazioni istopatogenetiche
No full textAlcohol and gastrointestinal cancers
No full textPurpose of reviewAlcohol is a type I carcinogen and the WHO stated that it caused 5% of all deaths in 2016, of which 13% because of cancers. Among digestive tract cancers, this association is clear for esophageal, liver and colorectal cancer, and more debated for gastric and pancreatic cancer. The present review will revise recent evidence on epidemiologic association and mechanisms linking alcohol with the risk of esophageal, gastric, colorectal and pancreatic cancers.Recent findingsModerate alcohol intake increases the risk of esophageal squamous cell carcinoma and colorectal cancer. Heavy alcohol intake is associated with an increased risk of gastric and pancreatic cancers. These risks also depend on genetic variants and the interaction with smoking is inconsistent. The carcinogenic mechanisms are multiple with a key role of acetaldehyde because of its ability to cause DNA damage, alter telomere length and induce ROS. Data on the role of the gut microbiome as possible mediator of alcohol-induced carcinogenesis are limited.SummaryThere is sufficient evidence for the association between alcohol consumption and cancers of the esophagus, stomach, colon-rectum and pancreas. Public health policies to prevent these cancer types should include modification of alcohol intake habits, especially among individuals at increased risk
EUS-guided gastroenterostomy in a COVID-19-infected patient with duodenal stenosing lymphoma (with videos)
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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