126,023 research outputs found
Use of Cocultures for the Study of Cellular Interactions Influencing B-Cell Regulatory Functions
No full textAlthough IL-10-producing B cells have been shown to play key roles in regulating immune responses involved in autoimmunity, inflammation, and cancer, the mechanisms at the base of the generation and maintenance of the pool of regulatory B cells are still poorly characterized. Several evidences show that the cross talk between B cells and other immune cell types promotes IL-10 production by B lymphocytes. Soluble mediators released into the microenvironment, together with direct cell-cell contact, are key signals in the process of regulatory B-cell development and differentiation. Here we describe the methods required to follow IL-10-producing B cells in MC- and MDSC-B-cell cocultures as examples of in vitro systems that induce the expansion of the regulatory B-cell population. These protocols can be also adapted for the study of other immune cell systems
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Interfacial reactivity and morphology at the Au/NiO(001) interface
No full textThe interest on metal-oxide interfaces is stimulated stimulated by the applications in many fields, such as catalysis, magnetic ecording, hard coatings. In the first stages of growth, gold nanoparticles dispersed on different oxides exhibit unusual electronic properties, depending on cluster size and gold-substrate interaction [1,2]. In particular a partial charge transfer
can occur, especially when the substrate is defective since gold tends to nucleate on oxygen vacancies. Thus the properties of goldoxide systems are critically dependent on interface reactions, in turn influenced by substrate preparation. A deeper understanding of the reactivity at the gold-oxide interface is essential to determine and control properties and behaviour of supported gold clusters. In this work we present a study of Au nucleation on top of 10 ML NiO film on Ag(001). By means of XPS, XPD and STM/AFM we studied electronic properties and morphology of the first stages of growth. It was previously reported that deposition of 15 A Au on NiO/Ag(001) causes oxide reduction [3]. We provide detailed and quantitative description
of the chemical interactions at this interface. From these results we aim to determine a relation between NiO reduction and morphological modifications (cluster formation and step decoration) in order to understand the driving force of the reduction process. Similar metal-oxide interfaces have been
also studied [4,5] to identify a general trend
in nucleation and reaction processes. In particular Fe, Pt on NiO and Fe, Pt, Au on MgO have been comparatively investigated.
[1] A. Sanchez, S. Abbet, U. Heiz, W.-D. Schneider, H. Hkkinen, R.N. Barnett, U. Landman, J. Phys. Chem. A 103(1999) 9573
[2] Z. Yang, R. Wu, D.W. Goodman, Phys. Rev. B 61 (2000) 14066
[3] R. de Masi, D. Reinicke, F. Mller, P. Steiner, S. Hfner, Surf. Sci. 515 (2002) 523
[4] S. Benedetti, P. Luches, M. Liberati, S. Valeri, Surf. Sci. 572 (2004) L348
[5] P. Luches, S. Benedetti, M. Liberati, F. Boscherini, I.I. Pronin, S. Valeri, Surf. Sci., in pres
L’adozione di standard di funzionamento e sviluppo e la classificazione degli istituti museali
No full textNeotrombicula valeri Kudryashova 1977
No full text<i>Neotrombicula valeri</i> Kudryashova, 1977 <p>(Fig. 26)</p> <p> <i>Neotrombicula valeri</i> Kudryashova, 1977: 47, fig. 1; Kudryashova <i>et al.</i> 1978: 125.</p> <p> <b>Diagnosis.</b> SIF = 7BS-N-3-2(3)111.1000; fPp = B/B/NbB; fSp = 7.7.7; fCx = 1.1.1(2); fSt = 2.2; fSc: PL> AL> AM; fD = 2H- 8-4-10-11 -6-5; DS = 46–58; VS = 44–51; NDV = 93–110; Ip = 984–1042; eyes 2 + 2; f 1 at level or slightly anterior to S 1; f 2 posterior to S 2. Measurements of type series (Kudryashova <i>et al.</i> 1978): AW 73–81, PW 95–105, SB 31–35, ASB 31–34, PSB 30–36, SD 62–67, AP 30–34, AM 36–39, AL 42, PL 56–62, S 84, H 56–59, D min 36, D max 56, V min 28, V max 48, pa 342–367, pm 291–316, pp 342–372. Measurements of holotype: AW 74, PW 95, SB 32, ASB 29, PSB 33, SD 62, P-PL 32, AP 30, AM 36, AL 40, PL 57, S 85, H 55, D min 41, D max 49, V min 28, V max 54, pa 315, pm 263, pp 310, Ip 888, TaIIIL 92, TaIIIW 16.</p> <p> <b>Type material examined.</b> Holotype larva (ZMMU Tdt-129, I-160-3842-43) from <i>Chionomys nivalis</i>, Mashhad 2, 1100 m a.s.l., 15–19 October 1970, coll. V.M. Neronov.</p> <p> <b>Hosts.</b> <i>Apodemus sylvaticus, Chionomys nivalis, Cricetulus migratorius</i>.</p> <p> <b>Distribution.</b> Iran (Mashhad 2).</p>Published as part of <i>Stekolnikov, Alexandr A., Saboori, Alireza, Shamsi, Mohsen & Hakimitabar, Masoud, 2019, Chigger mites (Acariformes: Trombiculidae) of Iran, pp. 1-66 in Zootaxa 4549 (1)</i> on pages 53-54, DOI: 10.11646/zootaxa.4549.1.1, <a href="http://zenodo.org/record/2584949">http://zenodo.org/record/2584949</a>
Distribution and excretion of 3H-dapiprazole in the rat
No full textTissue distribution as well as biliary, urinary and fecal excretion of 3H-dapiprazole was studied in the rat. The product is found in many tissues, including the brain. About 23 and 57% of the dose is excreted in the urine and feces and about 65% is eliminated in the bile. © 1985
Time-course of aspirin and salicylate in ocular tissues of rabbits.
No full textThe time courses of aspirin and salicylate in plasma and ocular tissues of rabbits were investigated after the i.v. administration of aspirin. Unhydrolyzed aspirin rapidly disappears from plasma and many ocular compartments but persists up to 4 hours in aqueous and vitreous humours. Salicylate decreases in plasma follow an exponential kinetics; in aqueous humour and in vascularized tissues the behaviour is similar but with a half-life longer than in plasma. In the cornea, lens and vitreous humour, the concentration of salicylate reaches a peak between 2 and 4 hours, then it decreases very slowly. Our results show that aspirin is protected from the hydrolytic action of plasmatic esterases in aqueous and vitreous humours but is rapidly hydrolyzed in the cornea and lens by local esterases present in these tissues. It is possible that both aspirin and salicylate leave the eye by means of an active transport. Our results also indicate that salicylate can accumulate in the cornea, lens and retina when aspirin is administered repeatedly
ABSORPTION OF BENDAZAC LYSINE AFTER TOPICAL APPLICATION TO THE RABBIT EYE
No full text[No abstract available
Giannozzo Manetti, Historia Pistoriensis, a cura di S.U. Baldassarri e B. Aldi (Edizione Nazionale dei testi della Storiografia umanistica), Firenze, Edizioni del Galluzzo, 2011
No full textLa Historia Pistoriensis di Giannozzo Manetti (1396-1459) fu data alle stampe per la prima e unica volta nel 1731, grazie a Ludovico Antonio Muratori il quale la inserì, con il titolo di Chronicon Pistoriense, nel XIX volume della sua monumentale raccolta delle fonti narrative della storia d’Italia, i Rerum Italicarum Scriptores. Dopo quasi tre secoli, l’“Edizione Nazionale dei testi della storiografia umanistica”, nell’ambito di un progetto editoriale più ampio dal titolo “Il ritorno dei classici dell’Umanesimo”, si è fatta carico della prima edizione critica di quest’opera, troppo a lungo trascurata o del tutto dimenticata
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