1,721,670 research outputs found
«Mi scriva dunque un suo Autoprofilo completo». Nota sul Profilo Autobiografico di Italo Svevo
No full textA partire dal ritrovamento presso l’archivio del Museo Sveviano della corrispondenza tra Italo Svevo e Mario Gastaldi, editore milanese attivo specialmente negli anni trenta del Novecento, il contributo si propone di precisare l’incerta tradizione del Profilo autobiografico. Le lettere riportate alla luce permettono di riformulare parzialmente i giudizi critici finora espressi e di fornire prove circa la paternità sveviana del documento in oggetto. Infine, un confronto tra il manoscritto-dattiloscritto di Giulio Cesari, che contiene un canovaccio dell’autobiografia modificata poi da Svevo, e il Profilo apparso già nel 1928 sotto forma di articolo di giornale e firmato da Gastaldi permetterà di verificare quali siano state le sostanziali varianti operate dall’autore triestino, confermando l’importanza e il carattere di eccezionalità di un testo che occorrerà riportare al centro degli studi sveviani.The aim of this paper is to clarify the textual tradition of Italo Svevo's Profilo autobiografico. Following the discovery of the correspondence between Svevo and the publisher Mario Gastaldi, it is now easier to prove that Svevo massively contributed to composing the text. Moreover, thanks to a comparison between new and old textual witnesses, it is now possible to identify the variants introduced by the author, which confirm the literary importance of the Profilo autobiografico for the modern studies on Italo Svevo's works
Effetti biologi dell'acido valproico su melanoma: studi in vitro ed in vivo
Full text linkÈ noto che il melanoma si sviluppa in conseguenza di alterazioni multifattoriali. Fin ad oggi numerosi studi indicano che l’alterazione di p16 individuato come gene soppressore del tumore, ha un ruolo importante nello sviluppo e/o nella progressione del melanoma umano. La crescita non regolata delle cellule del melanoma è stata associata con mutazioni nella via del ciclo cellulare che riguarda la fase G1: p16-cyclin D/cdk4-pRb. Recentemente le terapie anticancro si sono focalizzate sul ripristino della funzione oncosoppressoria di p16 e di altre proteine coinvolte nello stesso pathway che regola il ciclo cellulare nel melanoma (per esempio, c-myc, p27). Tra i nuovi agenti antitumorali stanno emergendo gli inibitori dell’ Istone deacetilasi (HDAC), che mostrano capacità nell’arrestare lo sviluppo di cellule tumorali essendo forti induttori di differenziamento cellulare ed attivando il processo apoptotico. Recentemente, si è studiata la capacità degli inibitori di HDAC di modulare le proteine che regolano il ciclo cellulare (per esempio, p21CIP1) e di determinare la down-regolazione dei fattori che inducono la proliferazione cellulare incontrollata. In questo studio abbiamo esaminato l'effetto dell’ acido valproico (VPA) in vitro, su due linee cellulare di origine umane di melanoma: M14 e JR8. Abbiamo osservato che il VPA induce arresto del ciclo cellulare e apoptosi del 50% nelle cellule M14 e del 55% nelle cellule JR8, con conseguente sensibilizzazione del tumore al trattamento di etoposide e cis-Platino. Il VPA, determinando il 75% d’arresto delle cellule in G1 del ciclo cellulare, favorisce l’aumento d’espressione di p16 sia a livello genico che proteico, in concomitanza ad una aumentata espressone delle proteine p21 e della ciclina D1. Per valutare la possibilità di usare il VPA come co-adiuvante nel protocollo terapeutico per il melanoma, sono state disegnate due differenti sequenze di somministrazione in vivo, di VPA e cis-Platino. Il trattamento concomitante del tumore (M14) in vivo, con VPA+cis-Platino determina una inibizione della crescita tumorale del 48%, confrontato con il controllo ed un effetto anti-metastatico di circa il 45%. La sequenza di trattamento con la combinazione cis-PlatinoVPA ha inibito la crescita tumorale di circa il 61% inducendo un significativo effetto anti-metastatico di circa il 70%. Inoltre l'espressione del gene p16 aumentava di circa 2,5 volte nei tumori trattati con il VPAcis-Platino confrontato con il controllo e il tumore trattato in singolo con il cis-Platino. L'abilità dell’acido valproico di ristabilire la fase G1 del ciclo cellulare nel melanoma sia in vitro che in vivo suggerisce una sua potenziale applicazione nei protocolli terapeutici del melanoma.It is known that melanoma develops as a consequence of multifactorial alterations. To date several studies indicate the effective implication of p16 as a tumor suppressor gene with a major role in either the development or progression of human melanoma. Deregulation of melanoma cell growth has been widely associated with mutations in the p16-cyclin D/cdk4-pRb pathway. Recently anticancer therapies are focused on restoration of p16 CDK inhibitory function and other proteins unregulated in melanoma cell cycle pathway (e.g., c-myc, p27). A combined strategy for restoration of normal homeostasis in the melanoma skin with targeted delivery of apoptosis-inducing agents does not seems to be far obtain.
New class of antitumoral agents are emerging: histone deacetylase (HDAC) inhibitors have attracted much interest because of their ability to arrest cell growth, induce cell differentiation, and in some cases, induce apoptosis of cancer cells. Recently, attention has been focused on the ability of HDAC inhibitors to induce perturbation in cell cycle regulatory protein (e.g., p21CIP1) and down-regulation of survival signalling pathway. In the present study, we have examined the effect of valproic acid (VPA) on M14 and JR8 human melanoma cell lines. Here we observed that VPA induces cell cycle arrest and apoptosis sensitising melanoma cells to cis-Platin and etoposide treatment. VPA was able to induce G1 arrest (up to 75 %) in association with up-regulation of p16, p21 and cyclin-D, inducing apoptosis (50 %) in M14 and JR8 (55%) cells.
To evaluate the possibility of VPA to be used as co-adjuvant in the chemotherapy protocol for melanoma, two different sequences of in vivo administration of VPA and cis-Platin were designed. The concomitant treatment of tumour (M14) in vivo, with VPA+cis-Platin induced a growth inhibition of 48% compared to control with an anti- metastatic effect of about 45%. The treatment sequence with VPAcis-Platin combination inhibited tumour growth in M14 of about 61% and induced an anti-metastatic effect of about 70%. Moreover p16 gene expression was found up-regulated 2,5-fold in tumor treated with the sequence VPAcis-Platin compared to control and cis-Platin single treated tumor. The ability of valproic acid to re-established the G1 pathway in melanoma both in vitro and in vivo suggests a potential application of VPA in melanoma therapeutic protocols
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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