18 research outputs found
An objective approach for digital removal of bifurcation aneurysms: incremental improvements?
No full textAutomated and objective removal of bifurcation aneurysms: incremental improvements, and validation against healthy controls
No full textBuilding credibility of computational models in cardiovascular medicine through verification and validation
No full text[EN] Cardiovascular diseases affect 15 million
people in Europe and digital solutions
are now seen as very useful tools in the
search for new drugs and medical devices.
SimCardioTest is a 4-year project funded
by the European Commission that aims to
develop credible computer modelling and
simulation approaches on a cloud-based
platform for testing cardiac drugs and
devices in silico.This project has received funding from the
European Research Council (ERC) under the
European Union s Horizon 2020 research and
innovation programme under grant agreement
No. 101078351.Setzu, R.;Olivares, A.;Mill, J.;Albors, C.;Cámara, Ó.;Valen-Sendstad, K.;Mora-Fenoll, María Teresa... (2024). Building credibility of computational models in cardiovascular medicine through verification and validation. The Project Repository Journal. 19:86-90. https://doi.org/10.54050/PRJ1921403S86901
Characterization of Vessel Wall Vibrations of an Arteriovenous Fistula Over the Maturation Period
No full textArteriovenous fistula (AVF) is the preferred vascular access for hemodialysis, but is still associated with a high failure rate. This study aims at characterizing AVF changes in vessel wall vibrations during the maturation period. Three-dimensional AVF models were generated from MR images
acquired 3 days and 6 weeks after surgery in a 72-year-old male patient. Blood velocities obtained from Ultrasound were imposed as boundary conditions for high-fidelity fluid-structure interaction simulations. Results showed predominant wall vibrations between anastomosis and perianastomotic vein, the typical areas where the stenosis develops, highlighting their potential role in the mechanobiological process responsible for AVF failure
A unified method for estimating pressure losses at vascular junctions
No full textIn reduced-order (0D/1D) blood or respiratory flow models, pressure losses at junctions are usually neglected. However, these may become important where velocities are high and significant flow redirection occurs. Current methods for estimating losses rely on relatively complex empirical equations that are only valid for specific junction geometries and flow regimes. In pulsatile multi-directional flows, switching between empirical equations upon reversing flow may introduce unrealistic discontinuities in simulated haemodynamic waveforms. Drawing from work by Bassett et al. (SAE Trans 112:565-583, 2003), we therefore developed a unified method (Unified0D) for estimating loss coefficients that can be applied to any junction (i.e. any number of branches at any angle) and any flow regime. Discontinuities in simulated waveforms were avoided by extending Bassett et al.'s control volume-based method to incorporate a 'pseudodatum' supplier branch, an imaginary effective vessel containing all inflow to the junction. Energy exchange between diverging flow streams was also accounted for empirically. The formulation was validated using high resolution computational fluid dynamics in a wide range flow conditions and junction configurations. In a pulsatile 1D simulation exhibiting transitions between four different flow regimes, the new formulation produced smooth transitions in calculated pressure losses
High-frequency wall vibration correlates with the growth of vertebrobasilar dolichoectasia aneurysm
No full text
Direct Numerical Simulation of Laminar-Turbulent Transition in a Non-Axisymmetric Stenosis Model for Newtonian vs. Shear-Thinning Non-Newtonian Rheologies
No full textNon‐Newtonian versus numerical rheology: Practical impact of shear‐thinning on the prediction of stable and unstable flows in intracranial aneurysms
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