1,720,964 research outputs found
Occurrence of seizures and EEG interictal epileptiform discharges in AD patients and their correlation with clinical features: a cross-sectional study
No full textAims: Several studies have shown that seizures and epilepsy have a higher incidence in Alzheimer’s disease (AD) than in the general population, even though with contrasting data (1), and the prevalence/ incidence of interictal epileptiform discharges (IEDs) in AD is still unclear. The aims of our study were: 1) to analyse the prevalence of seizures in a group of AD patients, 2) to investigate the prevalence/types of IEDs, 3) to assess whether IEDs/seizures occurrence correlate with any clinical features of patients. Materials: We included 167 patients with probable AD according to NIA-AA (2011), mild/moderate dementia, from a total sample (n = 245) of consecutive
demented outpatients seen at the Memory Center of the University of Pisa. Exclusion criteria where CDR>2, vascular lesions or other relevant CT/MRI lesions potentially affecting seizure threshold.In a subgroup of AD patients a further diagnosis of mixed dementia (MD) with mild-moderate vascular burden was performed by the mFazekas scale score. Detailed clinical/treatment data were collected. A validated questionnaire for anamnestic seizures screening (SQ)(2) to identify previous seizures of patients was administered to patients and caregivers;
SQ was administered also to caregivers (controls). 85 patients were randomized for standard EEG recording blindly to their SQ. Method: Cross-sectional analysis and correlation of collected data. Results: Age was 72,73 ± 6,52 y at AD onset, and 76,92 ± 6,38 y at observation; mean MMSE was 17,63 ± 6,03. 19.8% of patients had MD. A positive
SQ was found in 12,6% AD and 1,8% controls (p < 0.01). A higher prevalence of neuroleptic intake in the previous 3 months was found among patients with positive SQ than in those with no previous seizures (p = 0.009). Seizures reported were tonic-clonic generalized (52,38%), partial complex (42,86%), and simple partial ones (33,33%) (often co-existing). Seizures prevalence/types were similar in AD with and without MD. IEDs occurred in 14.12% of patient
EEG (sharp-waves: 75%; spikes: 18%; spike-waves complexes: 8%) and were mainly focal/multifocal. In patients without IEDs, cognitive impairment was higher than in those with EEG IEDs (p = 0.017). Discussion: We confi rmed AD is associated with higher risk of seizures. As seizure prevalence was similar in AD with and AD without MD we speculate that AD pathology is per se a crucial risk factor for seizures. The inverse relation between IEDs occurrence and cognitive decline might be in line with some data in AD experimental models. Conclusion: This cross-sectional study shows that AD pathology increases seizure and IEDs prevalence
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Detecting cognitive impairment at the early stages: The challenge of first line assessment
No full textDispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
- …
