1,721,016 research outputs found
SNEDDS pellets produced by wet granulation process to increase piroxicam dissolution rate
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Characterization of a quaternary liquid system improving the bioavailability of poorly water soluble drugs
No full textThe aim of this work is the characterization of the quaternary system composed of water, triacetin (oil), ethanol (alcohol), and Tween 80
(surfactant), as its results enable the enhancement of the bioavailability of nimesulide, a poorly water soluble nonsteroidal antiinflammatory
drug widely employed in the pharmaceutical field. Particular attention is devoted to the surfactant-free ternary system, as it proved able to
solubilize nimesulide as well, and the absence of a surfactant is desirable in order to keep the preparation as tolerable as possible. Both
bulk and interfacial properties of this system are investigated, and a mathematical model to calculate the interface composition of a threecomponent
two-phase system is developed. This model is based on Gibbs’ theory on interfaces, which considers an arbitrary mathematical
dividing surface so that the two phases continue uniformly up to it, although interface regions have no sharply defined boundaries. We find
that both the quaternary and the ternary systems investigated show a miscibility lacuna and that, in the surfactant-free ternary system, an
increase of the ethanol weight fraction is reflected as an impoverishment of the ethanol interfacial molar fraction
Preparation And Characterization Of A New Soluble And Bioactive Polymorph Of Praziquantel.
No full textBetter and greener: sustainable pharmaceutical manufacturing technologies for highly bioavailable solid dosage forms
Full text linkIn the last decades, Green Chemistry has been gaining widespread attention within the pharmaceutical field. It is thus very important to bring more sustainable approaches into the design and manufacture of effective oral drug delivery systems. This review focuses on spray congealing and mechanochemical activation, two technologies endorsing different principles of green chemistry, and at the same time, addressing some of the challenges related to the transformation of poorly water-soluble drugs in highly bioavailable solid dosage forms. We therefore present an overview of the basic principles, equipment, and application of these particle-engineering technologies, with specific attention to case studies carried out by the groups working in Italian Universities. Graphical abstract: [Figure not available: see fulltext.
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Experimental Design for Mixture Studies
No full textThis article focuses on the design and analysis of experiments with mixtures, very commonly involved in product development whenever a multicomponent system is concerned. Here, classical and computer-aided designs for mixture studies are introduced and discussed with various numerical examples. In fact, the strategies, which may be adopted by the experimenter for the construction of blending models in the region of interest, are quite different. The use of various methods and techniques for analysis and optimization are here illustrated by some case studies taken from practical experiences to analyse step by step the procedures adopted for the experimentation and the analysis of mixture data
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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