1,230 research outputs found
New Necklaces: 400 Designs in Contemporary Jewellery
No full textAfter the successful New Rings and New Earrings, New Necklaces is the third book curated by jeweller and author Nicolas Estrada, from classic forms and materials to the most daring, experimental and surprising ideas, each of the 500 necklaces included in this book has something that makes it unique and relates strongly to today's social, cultural and artistic reality. With prefaces by German jeweller Julia Wild and Leo Caballero, owner of the Barcelona gallery Klimt 02, specialised in contemporary jewellers
Heuristic Schelling: economy of organized crime
No full textThis article proposes a reading of the armed conflict from an evolutionary design that takes into account the concept of private protection agencies in the works of Schelling. Their aim is to assess the dynamics of conflict and changes from its author's scientific output. A context of conflicts that includes new expressions of violence and the relative failure of the paramilitary reintegration involves using new analytical models (argumentation, game theory and inconsistent information). The recent evolution of emerging gangs and their expansion into areas that were paramilitary camps requires monitoring not only of the government and the authorities, but those investigating the conflict in the present tense. The author provides heuristic research support from Schelling’s theory of strategy, recent contributions to the relationship between organized crime and drug cartels.Colombia, Government, Civil War, Latin America, Security, Protection Agencies.
El Tlacuache Núm. 116 (2004). 116 Año 4 (2004) febrero. El Tlacuache
No full text- Museos I: El Mundo por Elba Estrada Hernández. - El Yauhtli por Margarita Avilés y Macrina Fuentes. - Museos II: México por Elba Estrada Hernández
Dynamic reliability and security monitoring: a virtual machine approach
No full textWhile one always works to prevent attacks and failures, they are inevitable and situational awareness is key to taking appropriate action. Monitoring plays an integral role in ensuring reliability and security of computing systems. Infrastructure as a Service (IaaS) clouds significantly lower the barrier for obtaining scalable computing resources and allow users to focus on what is important to them. Can a similar service be offered to provide on-demand reliability and security monitoring?
Cloud computing systems are typically built using virtual machines (VMs). VM monitoring takes advantage of this and uses the hypervisor that runs VMs for robust reliability and security monitoring. The hypervisor provides an environment that is isolated from failures and attacks inside customers’ VMs. Furthermore, as a low-level manager of computing resources, the hypervisor has full access to the infrastructure running above it. Hypervisor-based VM monitoring leverages that information to observe the VMs for failures and attacks. However, existing VM monitoring techniques fall short of “as-a-service” expectations because they require a priori VM modifications and require human interaction to obtain necessary information about the underlying guest system. The research presented in this dissertation closes those gaps by providing a flexible VM monitoring framework and automated analysis to support that framework.
We have developed and tested a dynamic VM monitoring framework called Hypervisor Probes (hprobes). The hprobe framework allows us to monitor the execution of both the guest OS and applications from the hypervisor. To supplement this monitoring framework, we use dynamic analysis techniques to investigate the relationship between hardware events visible to the hyper-visor and OS constructs common across OS versions. We use the results of this analysis to parametrize the hprobe-based monitors without requiring any user input. Combining the dynamic VM monitoring framework and analysis frameworks allows us to provide on-demand hypervisor based monitors for cloud VMs.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2018-12-01The student, Zachary Estrada, accepted the attached license on 2016-10-10 at 09:21.The student, Zachary Estrada, submitted this Dissertation for approval on 2016-10-13 at 14:06.This Dissertation was approved for publication on 2016-10-17 at 08:32.DSpace SAF Submission Ingestion Package generated from Vireo submission #10179 on 2017-02-28 at 14:36:04Made available in DSpace on 2017-03-01T16:36:42Z (GMT). No. of bitstreams: 5
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Previous issue date: 2016-10-17Embargo set by: Seth Robbins for item 98574
Lift date: 2019-03-01T16:37:19Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Only Restriction Lifted for Item 98574 on 2019-03-02T10:15:07Z
Every nonsingular spherical Euclidean distance matrix is a resistance distance matrix
No full textThe communicability distance (Estrada (2012) [5]) is a useful metric to characterize alternative navigational routes in graphs. Here we prove that it is the resistance distance between a pair of nodes in a weighted graph. We extend this result and prove that every nonsingular Euclidean distance matrix is the resistance distance matrix of a weighted graph. We briefly analyze some mathematical properties of the communicability Laplacian matrix which emerges from the current analysis.The author thanks anonymous referee for important corrections on the original version. Financial support by the grant PID2019-107603GB-I00 of the MCIN/AEI/0.13039/501100011033/ is also acknowledged.Peer reviewe
Análisis estratégico de la situación de mercado para la idea de negocio “VM Boutique”
No full textVM Boutique, es una tienda especializada en productos de belleza que busca mejorar la experiencia de compra de sus clientes y su presencia en el mercado. Este proyecto nace
de la necesidad de ofrecer a los clientes una atención personalizada y de calidad, y de mejorar los procesos y estrategias de negocio para consolidar su posición en el mercado.
En VM Boutique, se cree en la importancia de la innovación y la mejora continua, y es por eso que se ha diseñado este proyecto con la finalidad de llevar la empresa al
siguiente nivel. A través de este proyecto, se busca mejorar la oferta de productos y servicios, fortalecer las relaciones con los clientes y proveedores, y expandir la presencia
en el mercado a través de una estrategia de marketing efectiva y una gestión eficiente de los recursos. Están seguros de que este proyecto será un gran éxito y les permitirá
consolidar a VM Boutique, como una tienda líder en el mercado de productos de belleza en la ciudad de Ibagué.Resumen -- Introducción -- Idea de negocio -- Misión -- Visión -- Valores -- Especialidades --Ubicación -- Análisis del entorno -- Estudio de mercado -- Plan estratégico -- Plan de marketing -- Plan de operaciones -- Plan de gestión humana -- Plan de finanzas -- Recomendaciones -- Bibliografía -- Anexos.Pregrad
The power to tax
No full textThis article describes the argumentative structure of Hayek on the relationship between power to tax and redistribution. It is observed throughout its work giving special attention to two works: The Constitution of Liberty (1959) and Law, Legislation and Liberty, vol3; The Political Order of Free People, 1979) Hayek describes one of the arguments most complete information bout SFP progressive tax systems (progressive tax). According to the author the history of the tax progressive system, works against such a tax model and deploys a variety of arguments in his favorite spot by critics: liberal democracy.Power to Tax, Redistribution, Government, Progressive Tax, Democracy, Hayek
The logic of the violence in the civil war: the armed conflict in Colombia
No full textThis paper proposes a reading of the armed conflict from an evolutionary design that takes into account the Logic of Violence in the Civil War. Their aim is to assess the dynamics of conflict and changes from its author's scientific output. A context of conflicts that includes new expressions of violence and the relative failure of the paramilitary reintegration involves using new analytical models (argumentation, game theory and inconsistent information). The recent evolution of emerging gangs and their expansion into areas that were paramilitary camps requires monitoring not only of the government and the authorities, but those investigating the conflict in the present tense. The author provides heuristic research support from Schelling’s theory of strategy, Nozick’s agencies and the protection, and Gambetta’s recent contributions to the relationship between organized crime and drug cartels.Civil_war, Colombia, armed conflict, strategic_theory, Gambetta, Nozick, Schelling
Ensayo y vida. El significado de Montaigne para Ezequiel Martínez Estrada
No full textIn his book-length essay on the life and works of Michel of Montaigne, the notable Argentinean essayist Ezequiel Martínez Estrada offered an incisive and beautifully written study on the famous French writer. Martínez Estrada's sympathetic literary portrait of the author of the Essays constitutes no only a kind of intellectual self-portrait of Martínez Estrada himself but also a deep reflection on the nature of the genera of the essay, of which the famous author of X-Ray of The Pampa was an accomplished artist. In this article both intertwined aspects are commented: Martínez Estrada personal identification with the individual Montaigne and his reflections on the scope and aims of essay-writing. Martínez Estrada linked the authenticity of the essay-writing, but of literature in general with its capacity to fully reflect life's richness, and, above all, 'people's' life.En su extenso ensayo sobre la vida y obra de Miguel de Montaigne el ensayista argentino Ezequiel Martínez Estrada ofreció un estudio incisivo y bellamente escrito sobre el famoso escritor francés. El favorable retrato literario que Martínez Estrada traza del autor de Les Essais constituye no solo una especie de autorretrato intelectual del propio Martínez Estrada, sino también una reflexión profunda sobre la naturaleza del género ensayístico, del que el autor de Radiografía de la pampa fue un artista consumado. En este artículo se comentan ambos aspectos entrelazados: la identificación personal de Martínez Estrada con el individuo Montaigne y sus reflexiones sobre el ámbito y fines de la escritura ensayística. Martínez Estrada ligó la autenticidad del ensayo, y de la literatura en general, con su capacidad para reflejar del todo la riqueza de la vida, y, sobre todo, la vida del 'pueblo'
Abstract P1-04-02: Improving immunotherapy response by epigenetic modulation
No full textAbstract
The presence of predicted neo-antigens in any given tumor is highly correlated with total somatic mutational burden of the same tumor genome. However, many potential neo-antigens are never transcribed, translated, or presented as antigens, partially because they lie in regions of the genome that are transcriptionally-repressed by cytosine methylation of promoter-CpG islands. Treatment with DNA methyltransferase inhibitors (DNMTi) can hypothetically lead to re-expression of many potential neo-antigens. Furthermore, the presence of neo-antigens have been linked to immunotherapy outcomes in patients. Our hypothesis is that tumors with reduced mutational burden can be maximized for neo-antigen presentation by activating transcription and translation of these sequences through DNMTi treatment. Our preliminary results showed that the DNMTi guadecitabine (SGI-110), a second-generation hypomethylating agent, treatment decreases methyl-cytosine in genomic DNA both in vitro and in vivo. In addition, SGI-110 treatment enhances MHC-II expression on murine mammary carcinoma MMTV-Neu cells upon IFN-γ stimulation in vitro and increases T-cell infiltration in vivo. Currently, we are performing whole-exome-sequencing and RNA-sequencing to track somatic mutations from DNA to RNA. We will further track somatic mutations from RNA→ MHC-presented peptide sequences using MHC immunoprecipitation followed by mass spectroscopy analysis. In addition, we will explore the role of guadecitabine therapeutic priming on response to αPD-L1 immunotherapy. These studies will provide a pre-clinical data to evaluate the potential for combined epigenetic and immune-therapy in a clinical trial for breast cancer.
Citation Format: Luo N, Estrada VM, Sanders ME, Balko JM. Improving immunotherapy response by epigenetic modulation [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr P1-04-02.</jats:p
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