170,090 research outputs found
ChemInform Abstract: Progress in the Development of Lysine Methyltransferase SETD8 Inhibitors
No full textProgress in the Development of Lysine Methyltransferase SETD8 Inhibitors —
[34 refs. + subrefs.]. — (MILITE, C.; FEOLI, A.; VIVIANO, M.; RESCIGNO, D.;
MAI, A.; CASTELLANO, S.; SBARDELLA*, G.;
ChemMedChem 11 (2016) 16, 1680-1685, http://dx.doi.org/10.1002/cmdc.201600272
; Dip. Farm., Univ. Studi Salerno, I-84084 Fisciano, Salerno, Italy; Eng.) —
Koehle
Cervical necrotizing fasciitis: report of clinical cases
No full textIntroduction: Necrotizing fasciitis (NF) is a rare soft tissue infection, usually polymicrobial, which causes necrosis of the fascia and subcutaneous tissue disorders not involving the skin1,2. It is characterized by rapid progression and destruction of the soft tissues of proportion to signs and clinical symptoms. The predisposing factors include diabetes mellitus, steroid therapy, chronic renal failure, cirrhosis, obesity, cancer, hypothyroidism, atherosclerosis, alcoholism, drug abuse, age and state of malnutrition.3,4 The states of immunosuppression plays an important role in determining the initiation, progression, and disease outcomes. A prompt diagnosis and immediate aggressive surgical debridement of all compromised tissues are critical to reducing morbidity and mortality in this type of infection.5
Materials and Methods: The study, unicentric and retrospective, was conducted at the Hospital "Santa Maria alle Scotte" in Siena (Italy). WE report patients'age, sex, medical status, origin of infection, bacteriology, surgical interventions, complications, survival, and other clinical parameters.
Results and Conclusions: The treatment of NF may be challenging and the keys to successful management appear to provide for the early detection of infection, high doses of appropriate antimicrobial therapy, and surgical intervention with radical debridement of necrotic tissue. Surgery remain the mainstay of treatment for NF.6
1.Changchien CH, Chen YY, Chen SW, Chen WL, Tsay JG, Chu C Retrospective study of necrotizing fasciitis and characterization of its associated Methicillin-resistant Staphylococcus aureus in Taiwan. BMC Infect Dis. 2011 Oct 31;11(1):297.
2. Lorenzini G, Picciotti M, Di Vece L, Pepponi E, Brindisi L, Vessio V, Maffei M, Viviano M.Cervical necrotizing fasciitis of odontogenic origin involving the temporal region - A case report. J Craniomaxillofac Surg. 2011 Dec;39(8):570-3
3. Banerjee AR, Murty GE, Moir AA. Cervical necrotizing fasciitis: a distinct clinicopathological entity? J Laryngol Otol. 1996 Jan;110(1):81-6.
4. Wong CH, Kurup A, Wang YS, Heng KS, Tan KC: Four cases of necrotizing fasciitis caused by Klebsiella species. Eur J Clin Microbiol Infect Dis 23(5): 403e407, 2004
5. Hunter J, Quarterman C, Waseem M, Wills A. Diagnosis and management of necrotizing fasciitis. Br J Hosp Med (Lond). 2011 Jul;72(7):391-5.
6. Tung-Yiu W, Jehn-Shyun H, Ching-Hung C, Hung-An C.Cervical necrotizing fasciitis of odontogenic origin: a report of 11 cases. J Oral Maxillofac Surg. 2000 Dec;58(12):1347-5
Lo Stato di Attività delle Imprese. L'impiego delle fonti amministrative per l'adattamento di un modello probabilistico
No full textThe use of data stored in administrative sources (or for tax purposes) is the best solution to reduce costs and problems relevant to statistical surveys on enterprises. As
pre-requisite aimed to this purpose there is the build-up of a business register (BR) to be used as frame for surveys. What affects quality of the BR for this purpose is the presence of errors due to the inclusion in the register of enterprises not carrying out a real activity or, on the contrary, the exclusion of those units active in economic sense. The present paper presents a probabilistic model to determine the activity status of an enterprise as relevant information to be included in the BR. In absence of specific statistical surveys available to estimate parameters, this paper describes an alternative method based on the use of representative groups of administrative information
Probabile ruolo delle parassitosi a penetrazione cutanea sulla trasmissione parenterale del virus dell'epatite B
No full textViviano, scriptor, notarius et iudex: un notaio al servizio della cancelleria ducale veneziana (1204-1223)
No full textIl saggio prende in considerazione la figura di Viviano, il primo notaio laico al servizio della cancelleria ducale veneziana nel primo quarto del XIII secolo, esaminando la sua attività e sottolineandone le caratteristiche
Demografia d'impresa: l'utilizzo di tecniche di abbinamento per l'analisi della continuità
No full textA record linkage procedure for the management and the analysis of the Italian statistical business register
No full textDifferent lineages of freshwater jellyfishes (Cnidaria, Olindiidae, Craspedacusta) invading Europe: another piece of the puzzle from Sicily, Italy
No full textCorrectly identifying and mapping the distribution patterns of passively dispersing freshwater organisms is an important task to understand the mechanisms through which these organisms move across the world and to counteract the introduction of invasive alien species in a timely way; moreover, in the light of the growing evidence of the pervasiveness of cryptic species and cryptic biological invasions among all animal groups, the use of molecular identification tools is strongly advisable. In this context, we present the first record of the freshwater jellyfish Craspedacusta sowerbii Lankester, 1880 in the Mediterranean island of Sicily, Italy. This invasive species, native to China, was found during a routine survey campaign aimed at assessing the freshwater species richness in the Sicilian region. Individuals were collected in November 2017 and identified to species level through the sequencing of fragments of both mitochondrial and nuclear genes, and their comparison to the sequences available on public databases. The analysis of molecular data proved that the Sicilian population belongs to C. sowerbii s.s., i.e. one of the two major Craspedacusta lineages which have been discovered to have invaded Europe and which were until recently erroneously jointly reported under the binomen Craspedacusta sowerbii. In order to get a clearer picture of the history and patterns of freshwater jellyfish invasion worldwide, the need for molecular identification of all the non-native Craspedacusta populations currently reported as C. sowerbii, and the opportunity of monitoring human-impacted ecosystems is stressed
Demografia d’impresa : l’utilizzo di tecniche di abbinamento per l’analisi della continuità
No full textContributi Istat n.
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