148 research outputs found
Valori e competizione. Storie di responsabilità sociale nella cooperazione bolognese
No full textIl libro presenta i risultati di una ricerca originale coordinata da Vittorio Capecchi tendente a verificare con quali modalità otto delle più importanti cooperative bolognesi aderenti alla Lega delle cooperative siano distanti dal modello neoliberista oggi predominante tra le imprese di maggiori dimensioni. Il libro è formato da un lungo saggio di Vittorio Capecchi dal titolo " Percorsi di un gruppo di cooperative bolognesi verso un modello di economia soloidale" a cui seguono nove saggi scritti da responsabili di otto coopertive e da chi ha la responsabilità di Impronta Etica. Il libro ha una premessa di Giampiero Calzolari, una introduzione di Doriana Ballotti e una post fazione di Pier Luigi Sacco
Active versus borderline myocarditis: clinicopathological correlates and prognostic implications.
No full textOBJECTIVE: To compare active (AM) with borderline (BM) myocarditis to verify whether the pathological distinction between the two forms may help to identify patients with different clinical and haemodynamic characteristics and to aid prognosis.
MATERIALS: Myocarditis was diagnosed in 56 patients on endomyocardial biopsy (EMB) within one year from clinical onset of the disease between 1991 and 1998. Fourteen patients were excluded because of a lack of adequate and complete information. EMBs and clinical records of the 42 remaining patients were reviewed. Immunohistochemistry on bioptic samples was regularly performed. Polymerase chain reaction (PCR) for a panel of viruses was performed in 23 patients (55%). Clinicopathological correlations were calculated.
RESULTS: The histological diagnosis was AM in 26 patients (62%) and BM in 16 (38%). Significant differences were found in the following parameters: presence of left bundle branch block on ECG (AM 2 (8%) v BM 5 (31%), p = 0.05); left ventricular volume on echocardiogram (mean (SD) AM 90 (42) ml/m(2) v BM 128 (50) ml/m(2), p = 0.002); mass to volume ratio (AM 1.0 (0) v BM 0.8 (0.1), p = 0.03); time interval between clinical onset of the disease and EMB (AM 40 (55) v BM 90 (93) days, p = 0.04); and degree of inflammatory infiltrates, scored on a scale of 0 to 3 (AM 1.65 (0.8) v BM 0.85 (0.3), p = 0.004). In 6 of 15 patients (40%) with AM and in 2 of 8 (25%) with BM, a viral genome was detected by PCR (NS). At follow up, no differences in death or heart transplantation were detected between the two forms (AM 4 patients (15%) v BM 2 patients (12.5%)). Three of eight PCR positive patients (37.5%) and 1 of 15 virus negative patients (7%) died or underwent heart transplantation.
CONCLUSIONS: BM seems to encompass inflammatory forms with a less aggressive inflammatory infiltrate evolving towards left ventricular dilatation. The term "chronic myocarditis" seems to be more appropriate. The absence of myocyte necrosis does not predict a more favourable prognosis, whereas the absence of a viral genome seems to predict it
Myocarditis mimicking acute myocardial infarction: role of endomyocardial biopsy in the differnetial diagnosis
No full text
Histologic findings in the conduction system after cardiac transplantation and correlation with electrocardiographic findings.
No full textSix3 controls the neural progenitor status in the murine CNS
No full textSix3, a homeodomain-containing transcriptional regulator belonging to the Six/so family, shows a defined spatiotemporal expression pattern in the developing murine telencephalon, suggesting that it may control the development of specific subsets of neural progenitors. We find that retrovirus-mediated misexpression of Six3 causes clonal expansion of isolated cortical progenitor cells by shortening their cell cycle and by prolonging their amplification period, while maintaining them in an immature precursor state. Our results show that the observed effects exerted by Six3 overexpression in mammalian brain depend strictly on the integrity of its DNA-binding domain, suggesting that Six3 action likely relies exclusively on its transcriptional activity. In vivo upregulation of Six3 expression in single progenitor cells of the embryonic telencephalon keeps them in an undifferentiated state. Our observations point to a role of Six3 in the control of the subtle equilibrium between proliferation and differentiation of defined precursor populations during mammalian neurogenesis. © The Author 2007. Published by Oxford University Press. All rights reserved
Mapping of human thyroglobulin gene on the long arm of chromosome 8 by in situ hybridization.
No full textMielopatie cervicali compressive da cause rare: analisi clinica e neurologica
No full textvalutazione clinico-strumentale di mielopatie cervicali da cause rare. analisi di una casistic
Detection of Usutu Virus Within a West Nile Virus Surveillance Program in Northern Italy.
No full textUsutu virus (USUV) is a mosquito-borne flavivirus belonging to the Japanese encephalitis serocomplex, recently
related to neurological disease in immunosuppressed patients. In the same area of Northern Italy where USUV
human cases occurred in 2009, a regional West Nile virus (WNV) surveillance program based on mosquito
monitoring and wild birds screening has been implemented since 2008. Mosquito pools and wild birds were
tested using three different polymerase chain reactions (Flavivirus, WNV, and USUV). During summer 2009, 56
pools (54 consisting of Culex pipiens and 2 of Aedes albopictus) and 27 pools (Cx. pipiens) out of 1789 mosquito
pools were, respectively, USUV and WNV positive. Moreover, out of 1218 wild birds tested, 44 were WNV
positive, whereas only 11 birds were USUV positive by polymerase chain reaction. Data collected during 2009
prove a cocirculation of USUV and WNV in Northern Italy, but these two viruses show different incidence
values in both mosquitoes and birds, suggesting involvement of different animals (other bird species or
mammals) in their natural cycles. The cocirculation of WNV and USUV poses a new potential threat to human
health in this area. The extent of WNV surveillance to other Flaviviruses will require new diagnostic procedures
able to process a large number of samples in a limited period of time and highlights the importance of developing
more specific serological tests that could be used in field
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