1,720,990 research outputs found
A new monoclonal antibody against DNA ligase I is a suitable marker of cell proliferation in cultured cell and tissue section samples.
No full textDevelopment of an aeronautical crashworthy seat for the fatal injuries using design of experiments
No full textThe main topic of the paper is the definition of the optimal design of an aeronautical seat, in terms of maximization of occupants’ safety level and of prediction capability of a FE/MB coupled numerical procedure, based on TNO Madymo® MB software and LSTC LS-Dyna® FE software. The proposed numerical procedure can support the physical prototype development and the experimental phase of the current design approach by using design of experiments methods.
In particular, the paper deals with the simulation of an experimental seat sled test against the aircraft front fuselage bulkhead (Figure 1). The FE model has been analysed by using LSTC-LsDyna® code; the multibody model has been analysed by considering TNO-Madymo code.Parameters evaluated during the tests are the acceleration of the head, with the relative calculation of HIC, and the loads transmitted to the lower limbs of the dummy.
To approach the development phase, it may result very effective to take into account previous experiences, before entering the cumbersome development of the detailed finite element model.
The implementation of simplified multibody (MB) structural models, together with design of experiment (DOE) may simplify the definition of the crashworthy scenario for a new seat.
Though the adoption of an integrated MB and DOE approach will not eliminate the need for a detailed FE impact model and its experimental validation, it will surely help in identifying the most sensitive parameters to be complying with the applicable regulation (from the numerical simulation point of view) and in reducing the number of tests needed to reach the certification requirements.
The paper presents the initial attempt in applying such development strategy, highlighting the importance of previous experience and how to take advantage from it through dedicated self- developed computer tools
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
B cells in rheumatoid arthritis: from pathogenic players to disease biomarkers
No full textThe therapeutic benefit of depleting B cells in rheumatoid arthritis (RA) has refocused attention on B cells with increasing awareness on their role in autoimmunity and their function beyond autoantibody production. The rapid increase in our comprehension of B-cell pathobiology is progressively opening novel perspectives in the area of B cell-targeted therapies with the expectation to define more specific approaches able to preserve the homeostasis of the humoral response while disrupting the pathogenic components. In parallel, B-cell activity in RA is starting to be explored in its clinical value, in search of novel biomarkers embedded in the pathogenic process that could help classifying the disease and predicting its heterogeneous outcome beyond inflammation dynamics. In this review, we summarize current knowledge on the multiple roles that B cells play in several aspects of RA. We also analyze their distribution and potential function in different anatomic compartments with specific reference to the main sites in which the disease may be sustained and exert its detrimental effects: the systemic circulation, synovium, bone marrow, and draining lymph nodes. We also highlight novel data encouraging further research in the field of biomarkers related to B cells and their regulatory factors
A model-based approach for the analysis of aircraft seating comfort
No full textBACKGROUND: Aircraft seating comfort has a significant impact on passenger on-board experience. Its assessment requires the adoption of well-designed strategies for data collection as well as appropriate data analysis methods in order to obtain accurate and reliable results. OBJECTIVES: This paper focuses on the assessment of aircraft seating comfort based on subjective comfort responses collected during laboratory experiments and taking into account seat features and passenger characteristics. METHODS: The subjective comfort evaluations have been analyzed using a model-based approach to investigate the relationship between overall seating comfort and specific seat/user characteristics. RESULTS: The results show that the overall seating comfort perception is significantly influenced by the thickness of the seat pan, the backrest position (upright or reclined), the age of the passenger and the passenger perception of being comfortably supported at the lumbar region. CONCLUSIONS: The adopted model-based approach allows the analysis of subjective seating comfort data taking into account their ordinal nature as well as the dependency between evaluations provided by the same subject
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
- …
