3,088 research outputs found
Assessing the effects of local contexts on the mobility choices of university students in Campania region in Italy
No full textThe mobility of university students in Italy has been framed as a phenomenon linked to so-called intellectual migrations and as a subset of the historical and consolidated internal migration path explained in terms of South–North trajectory. This study describes the most important mobility trajectories of students across macro-areas and disciplinary fields, and then evaluates, using a multilevel logistic regression model, the factors that encouraged student cohort, who were enrolled in a degree program in the academic years 2014–2015, to move elsewhere from the Campania region. Beyond fixed and interaction effects related to the students’ personal characteristics, the model included possible random effects linked to the high schools attended by the students to capture the possible influence of the local context on migration choices
Risk factors for recurrence of deep infiltrating endometriosis after surgical treatment
No full textAim: To evaluate the frequency of complications and factors associated with the recurrence of endometriosis in women with deep infiltrating endometriosis (DIE) undergoing surgical treatment.
Methods: A retrospective observational cohort study with 72 women who underwent surgery and followed up by DIE at the University of Campinas from 2007 to 2017. The variables analyzed were clinical characteristics, use and type of drug treatment before and after surgery, operative time and complications inherent to the procedure, as well as the recurrence of lesions on imaging.
Results: The mean age of women was 39.7 ± 6.3 years and the mean follow-up was 4.56 ± 2.60 years. Complications were reported in 16.6% of surgeries and recurrence of lesions in 34.7%. The risk of intraoperative complications was higher in the presence of lesions of the bowel and in those who used intramuscular progestin before surgery. A higher risk of recurrence was observed among those who did not use hormonal treatment or used a levonorgestrel-releasing intrauterine device (LNG-IUD) in the postoperative period.
Conclusion: Women with DIE have a high rate of complications during surgical treatment and a higher risk of recurrence when they did not receive hormonal treatment or when treated with LNG-IUD after surgery
Application of the IS-MP-IA model to the German economy and policy implications
No full textExtending the IS-MP-IA model developed by Romer (2000) and applying the GARCH (Engle, 1982, 2001) methodology, the author finds that equilibrium GDP in Germany is positively affected by stock market performance and real exchange rate appreciation, and negatively influenced by the expected inflation rate, the government deficit/GDP ratio, and the U.S. federal funds rate. The relatively low deficit/GDP ratio of 1.83% in 2003 indicates that its fiscal condition was healthy. However, some other EU members may need to exercise fiscal discipline. Because real appreciation has a positive impact on output, a stronger euro may not be a concern for Germany but may be worried by those EU member nations which depend upon exports to stimulate their economies.
Winning redefined, a new brand positioning for MP Motorsport
No full textMP Motorsport is a talent educating race team participating in the classes below the Formula 1. The problem with the lower classes and therefore MP Motorsport as well is that these classes don’t get much attention and exposure. As a company run by people with passion the branding and positioning is more something that naturally emerged from this passion rather than a series of conscious decisions. This makes it fragile. A more conscious strategy and vision on how MP Motorsport needs to be branded and positioned against their competition that is more than “look how cool racing is” is needed to become more attractive for sponsoring. This report describes the process from analysis to finding the right positioning and an advise for a new brand identity and an implementation plan to help becoming more attractive for sponsoring goals. The analysis done with employees showed a unique characteristic that will help the team to position themselves against the competition; the family atmosphere. This atmosphere is what also characterises their contradictory personality. This personality is on one hand leading and ambitious and on the other hand modest and involved. Competition and stakeholder analysis have been performed to find the right combination of being unique to the competition, desirable for the stakeholders (the fans and sponsors) and builds upon the core strengths of the company. Then using the brand key model, a positioning is made with the essence: Be your best self. The belief, “in everyone hides a talent” and values like “everyone is equal” and “together we succeed” combined with the essence and the positioning resulted in a brand story that describes the feeling MP Motorsport wants to communicate. To manifestate the brand, an advise has been set up for a tone of voice and tone of image. Wrapped in a concept called “winning redefined” this advise is part of the whole implementation plan that should lead the way for the team to implement the newly created brand in short and long term actions. In 3 phases MP Motorsport is advised to start with a clear brand introduction to the target groups Gen Z and potential sponsors. The next phase revolves around creating a community to attract both Gen Z talents and subsequently sponsors to interact with the team and each other. Finally the last phase is long term focused and aims for sustainable growth. In this phase the community is established and can expect various opportunities to discover and develop a whole range of talents, sponsors and gen z are connected to each other via MP Motorsport and the team is able to finance the lower classes without the pressure of the money drivers bring along.Strategic Product Desig
Derivations (MP) and Evaluations (OT)
No full textThe main claim of this paper is that the minimalist framework and optimality theory adopt more or less the same architecture of grammar: both assume that a generator defines a set S of potentially well-formed expressions that can be generated on the basis of a given input, and that there is an evaluator that selects the expressions from S that are actually grammatical in a given language L. The paper therefore proposes a model of grammar in which the strengths of the two frameworks are combined: more specifically, it is argued that the computational system of human language CHL from MP creates a set S of potentially well-formed expressions, and that these are subsequently evaluated in an optimality theoretic fashion.The definitive version of this paper is published in Linguistics in Potsdam 25 (2006).Broekhuis, H. (2006). Derivations (MP) and Evaluations (OT)*. In H. Broekhuis & R. Vogel (Eds), Linguistics in Potsdam 25. Optimality Theory and Minimalism: A possible Convergence? Potsdam : Universitätsverlag PotsdamISBN: 9783939469544 (published book)This research is supported by the Netherlands Organisation of Scientific Research (NWO), grant 276-70-00
Stroom- en sedimentmeting Roompot-Veerse Dam (mp.8), 15 en 22 januari 1996
No full textStroom- en sedimentmeting Roompot-Veerse Dam (mp.8) 15 en 22 januari 1996.Deltawerken, Oosterscheld
A novel approach to MP-PIC: Continuum particle model for dense particle flows in fluidized beds
No full textA novel approach to Multiphase-Particle-in-Cell (MP-PIC), called Continuum Particle Model (CPM), is developed for dense gas-particle flows. CPM has high computational speed, comparable to that of MP-PIC, but a robustness and accuracy closer to that of a Discrete Element Model (DEM). The gas phase is treated as a continuum phase and particles are tracked discretely, but particle collisions are modelled by considering the divergence of the continuum particle stress tensor. Details on efficient solution to the model are presented. For comparison, a parametric study is performed for quasi-2D fluidized beds. Comparison of CFD-CPM is made with MP-PIC and CFD-DEM. The particle stress models by Harris and Crighton, and by Srivastava and Sundaresan are tested in our CFD-CPM. Results from CFD-CPM based on the Srivastava and Sundaresan particle stress model show good agreement with CFD-DEM results. We validate our model by comparison with experimental benchmark results from Gopalan et. al. (2016).Complex Fluid Processin
Role of type I Interferons in the treatment of endocrine and non-endocrine cancers
No full textGli interferoni (IFNi) costituiscono una complessa famiglia di citochine, individuate inizialmente per la loro capacità di conferire uno stato anti-virale alle cellule. Successivamente, altri effetti biologici sono stati attribuiti agli IFNi, tra i quali una potente attività anti-tumorale. In relazione al tipo di recettore con cui interagiscono, gli IFNi sono stati classificati in due gruppi: IFNi di tipo I (IFN-, -, - and -) e IFNi di tipo II (IFN-).
L’attività di ricerca svolta dal candidato durante il corso di Dottorato ha avuto come obiettivo quello di valutare l’efficacia in vitro dell’IFN- e IFN- in linee cellulari umane di tumore neuroendocrino del pancreas (BON), adenocarcinoma del pancreas (BxPC-3, MiaPaCa-2, Panc-1) e carcinoma del surrene (SW-13, H-295), e di analizzare i meccanismi d’azione ed il ruolo delle relative subunità recettoriali.
Gli effetti dell’IFN-2b e IFN-1a sulla proliferazione cellulare sono stati valutati tramite la quantificazione del DNA, rappresentativa del numero delle cellule, mediante determinazione fluorimetrica con il colorante fluorescente HoechstTM 33258. In tutte le linee cellulari che abbiamo testato, l’effetto inibitorio dell’IFN- risulta essere dose-dipendente e maggiore dell’IFN-. L’attività antitumorale dell’IFN- è prevalentemente dovuta all’arresto del ciclo cellulare, con accumulo delle cellule in fase S, evidenziato mediante lo studio dell’incorporazione di ioduro di propidio con la citometria a flusso (FACS). Mentre, l’IFN-, oltre ad indurre un ritardo di transizione delle cellule dalla fase S a G2M, ha un potente effetto stimolatorio sull’apoptosi in quasi tutte le linee cellulari esaminate. L’espressione dell’mRNA e delle proteine per le subunità recettoriali attive degli IFNi di tipo I (IFNAR-1 e IFNAR-2c) e’ stata identificata rispettivamente mediante RT-PCR quantitativa ed immunoistochimica in tutte le cellule esaminate. E’ interessante notare nelle linee cellulari di adenocarcinoma pancreatico le relazioni riscontrate tra la responsività alla terapia, l’espressione e la distribuzione delle due subunita’ recettoriali. L’analisi quantitativa alla RT-PCR dell’mRNA per IFNAR-1 e IFNAR-2c rivela una maggiore espressione nelle BxPC-3, la linea cellulare più sensibile agli IFNi di tipo I. L’immunoistochimica, oltre a confermare la superiore espressione del recettore nelle BxPC-3, evidenzia anche differenze nella localizzazione e distribuzione cellulare. Mentre nelle BxPC-3 le subunità IFNAR-1 e IFNAR-2c sono principalmente localizzate a livello della membrana cellulare, nelle Panc-1 (le cellule maggiormente resistenti alla terapia con IFN-/IFN-) il segnale è prevalentemente citoplasmatico, con una lieve positività membranosa. Pertanto, la maggiore sensibilità alla terapia con IFN nelle BxPC-3 potrebbe essere legata all’elevata espressione recettoriale, evidenziata prevalentemente a livello della membrana cellulare. L’IFN- sembra anche essere in grado di modulare l’espressione di importanti fattori di crescita tumorali. Infatti, nelle BON e H-295, cellule in grado di produrre grandi quantità di IGF-2, l’IFN- inibisce la trascrizione di tale fattore di crescita.
Infine, l’attività di ricerca è stata finalizzata all’identificazione di nuove strategie volte alla sensibilizzazione delle cellule tumorali all’azione dell’IFN-. L’IFN- a concentrazioni citostatiche aumenta l'espressione e la funzione del recettore per l'epidermal growth factor nelle cellule KB di carcinoma umano epidermoide, costituendo una risposta protettiva all'apoptosi indotta dall'IFN-. Abbiamo evidenziato che le cellule KB antagonizzano l'effetto antiproliferativo ed apoptotico dell'IFN- attraverso l'iperattivazione della cascata delle chinasi attivate da mitogeni (MAPK) dipendente da ras. Pertanto, il targeting selettivo di tale via metabolica potrebbe essere un valido strumento per eludere i meccanismi di resistenza all’IFN- attivati dalla cellula. Infatti, l’inibizione selettiva di ras, attraverso la trasfezione del dominante negativo di ras RASN17 nelle cellule KB, potenzia l'apoptosi indotta da IFN come determinato con analisi al FACS e tecnica TUNEL. Analogo potenziamento dell’attività apoptotica dell’IFN- è stato evidenziato dall’associazione con un inibitore selettivo di MEK-1 (PD 98059), a sua volta attivatore selettivo di ERK-1/2
In vivo generation of patient-specific cytotoxic T cell clones (CTL), following donor lymphocyte infusions (DLI) for chronic myeloid leukemia after HLA genotypically identical BMT
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