1,720,989 research outputs found
The role of PET18 F-FDOPA in the evaluation of low grade gliomas.
Full text link1) Low grade gliomas are in general relatively slow-growing brain tumor, but they have a very heterogeneous clinical and biomolecular behavior.
2) The optimal treatment of low grade glioma remains controversial, i.e “wait-and-see” versus treatment.
3) The MRI is considered the gold standard in the evaluation of low grade glioma, but has several limitations. Since the glioma growth does not obey an exponential evolution due to the diffusion of many newly produced tumor cells into the surrounding parenchyma. Therefore, the tumor density does not reach the minimal threshold required to appear on MRI.
4) The PET 18 F-FDOPA has good sensitivity and specificity in the evaluation of brain tumor recurrence, mainly in the evaluation of the recurrence of low grade or high grade malignant gliomas.
5) In our study, PET 18 F-FDOPA demonstrated not a potential diagnostic role, but also a prognostic value in predicting progression of disease
Relazioni sociali e didattica a distanza
No full textIl presente lavoro mette in luce la capacità del mondo accademico di sapersi
adattare velocemente ad una situazione per certi versi “nuova”, in cui
la didattica tradizionale deve cedere il posto alla didattica a distanza per far
fronte ad un’emergenza che trova impreparati docenti e studenti. Dall’analisi
empirica dei dati è possibile evidenziare la volontà di affrontare e superare
le difficoltà, finalizzata ad evitare il blocco della trasmissione dei saperi, considerando
anche i limiti ai processi di socializzazione tra docenti e discenti e
tra discenti stessi (connessi all’utilizzo di una didattica on line)
Polytherapy for migraine prophylaxis
No full textMigraine is a chronic neurological disorder with episodic manifestations, progressive in some individuals. Preventive treatment is recommended for patients with frequent or disabling attacks. A sizeable proportion of migraineurs in need of preventive treatment does not significantly benefit from monotherapy. This short review evaluates the role of pharmacological polytherapy in migraine prevention
Migraine and metabolism
No full textMigraine is a chronic disorder with complex pathophysiology involving both neuronal and vascular mechanisms. Migraine is associated with an increased risk of vascular disorders, such as stroke and coronary heart disease. Obesity and diabetes are metabolic disorders with a complex association with migraine. Insulin resistance, which represents the main causal factor of diseases involved in metabolic syndrome, is more common in patients with migraine. A better understanding of the relationship between metabolic syndrome and migraine may be of great clinical interest for migraine management
Migraine and lifestyle in childhood
No full textMigraine is one of the most frequently reported somatic complaints in childhood, with a negative impact on health-related quality of life. The incidence of migraine in childhood has substantially increased over the past 30 years, probably due to both increased awareness of the disease and lifestyle changes in this age group. Indeed, several conditions have been identified as risk factors for migraine in childhood. Amongst these, dysfunctional family situation, the regular consumption of alcohol, caffeine ingestion, low level of physical activity, physical or emotional abuse, bullying by peers, unfair treatment in school and insufficient leisure time seem to play a critical role. Nevertheless, there are only few studies about the association between migraine and lifestyle in childhood, due to previous observations specifically focused on "headache" in children. In this brief review, we will concentrate upon recent studies aimed to explore migraine and lifestyle risk factors in childhood
Zonisamide for Migraine Prophylaxis in Topiramate-Intolerant Patients: An Observational Study
No full textBackground.- Zonisamide, a sulfonamide analog, is an antiepileptic drug with mechanisms of action similar to topiramate. Because of its pharmacodynamic and pharmacokinetics profiles, zonisamide is also potentially suitable for migraine prevention. Methods.- Tolerability and effectiveness of zonisamide for migraine prophylaxis in patients with a good response to topiramate, but interrupting it for intolerable side effects, were evaluated in 34 patients. After a 1-month period of wash-out, patients were treated with zonisamide (up to a 100 mg/day dosage) for 6 consecutive months. Results.- Zonisamide was well tolerated, only 4 (12%) patients reported transient and tolerable side effects. Mean number of days with headache per month was reduced from 14.9 +/- 5.3 during the wash-out period to 2.5 +/- 0.6 after 6 months of zonisamide (P < .001). We observed a significant reduction in headache severity and disability, as assessed by visual analog scale and migraine disability assessment scale. Finally, when compared with the 1-month period prior to starting zonisamide, a reduced use of analgesics was recorded at the end of the follow-up. Conclusion.- Our findings support the use of zonisamide as an alternative therapy for migraine prevention in patients with good response, but poor tolerance to topiramate
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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