1,720,994 research outputs found
Letter by toscano et al regarding article. association of leukoaraiosis with convalescent rehabilitation outcome in patients with ischemic stroke
Full text linkGiven the aforementioned link between leukoaraiosis and swallowing impairment, and the burden of poststroke dysphagia on rehabilitation outcome, it could be of some interest to analyze the relationships between leukoaraiosis, recovery, and dysphagia in your large population
EEG SIGNALS IN EPILEPSY AND MIGRAINE: Analysis and Simulations by Multi-Agent Systems
No full textThe preliminary results of some observations carried out on the spectral content of EEG signals from migran-ious and epileptic individuals and, in particular, on the spatio-temporal correlation of the neuronal activation in the two pathologies, are presented. In the aim to simulate the qualitative features of EEG signals associated to migraine and epilepsy, we used a computational approach based upon Pearson correlations and a Multi Agent System. Our findings, although still not conclusive, revealed considerable heuristic power on the sole assumption of a similar synchronization process of the underlying neuronal population, and may provide in the long term useful hints to a very difficult problem
MIGRAINE AND EPILEPSY: LOOKING FOR A COMMON PATHOPHYSIOLOGICAL MODEL
No full textThis contribution reports about the results gathered from in-silico experiments testing the feasibility of a research
program based upon a common pathophysiological mechanism for migraine and epilepsy. In a rst set of experiments,
the Electroencephalographic (EEG) signals from couples of corresponding electrodes in the two cerebral emispheres,
as well as from couples of continguous electrodes in the left and right emisphere, were systematically correlated. In
both cases, the existence of ordered distributions of activity patterns in the EEG signals from migranious and epileptic
subjects was qualitatively assessed. In a subsequent and crucial set of experiments, we were able to obtain some
spatially ordered and oscillating synchronization patterns of virtual neurons distributed over a bidimensional region,
by means of a multi-agent simulation environment (Netlogo). On the basis of such results, a further development
of our research program including the enrichment of the data set and the consideration of other powerful simulation
approaches, e.g. Articial Neural Network (ANN) or Genetic Algorithms (GA), seems in the good track of realizing
a realistic simulation of the Cortical Spreading Depression Waves, potentially useful even for clinical purposes
The therapeutic potential of duloxetine in prostate cancer-related fatigue.
Full text linkCancer-related fatigue (CRF) is a common polysymptomatic syndrome with no standard therapy. The authors present the case of a prostate cancer patient in whom, during hormone therapy, disabling CRF and urinary incontinence occurred. CRF was assessed according to the brief fatigue inventory (BFI). The patient received duloxetine, 60 mg daily, due to its impact on both CRF and incontinence. After 2 months, the BFI score decreased (from 9 to 2) and urinary incontinence resolved. After duloxetine discontinuation, the patient maintained a low BFI score. The authors conclude that, as a serotonin-noradrenaline reuptake inhibitor, duloxetine could be active on prostate CRF, especially with associated urinary symptoms. Therefore, a pilot placebo-controlled trial with duloxetine to treat prostate CRF may be worthwhile
Alice in wonderland syndrome. a clinical and pathophysiological review
Full text linkAlice in Wonderland Syndrome (AIWS) is a perceptual disorder, principally involving visual and somesthetic integration, firstly reported by Todd, on the literary suggestion of the strange experiences described by Lewis Carroll in Alice in Wonderland books. Symptoms may comprise among others aschematia and dysmetropsia. This syndrome has many different etiologies; however EBV infection is the most common cause in children, while migraine affects more commonly adults. Many data support a strict relationship between migraine and AIWS, which could be considered in many patients as an aura or a migraine equivalent, particularly in children. Nevertheless, AIWS seems to have anatomical correlates. According to neuroimaging, temporoparietal- occipital carrefour (TPO-C) is a key region for developing many of AIWS symptoms. The final part of this review aims to find the relationship between AIWS symptoms, presenting a pathophysiological model. In brief, AIWS symptoms depend on an alteration of TPO-C where visual-spatial and somatosensory information are integrated. Alterations in these brain regions may cause the cooccurrence of dysmetropsia and disorders of body schema. In our opinion, the association of other symptoms reported in literature could vary depending on different etiologies and the lack of clear diagnostic criteria
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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