1,721,637 research outputs found
Pathological definitions of invasion, metastatic potential and responsiveness to targeted therapies.
No full textThe tailored treatment of patients with primary breast carcinoma relies mainly on the assessment of invasion, metastatic potential and responsiveness to targeted therapies. Accordingly, the role of the pathologist is to ensure the most accurate evaluation of the prognostic and predictive parameters, which will have a major impact in the planning of the adjuvant interventions. Every effort has to be made to improve the accuracy and the inter-laboratory reproducibility of the histopathological and biological characterization of breast carcinomas, taking advantage of the newly developed molecular assays. This review article will focus mainly on some controversial issues, like intracystic papillary carcinomas, whose invasive or non-invasive nature is still debated; the suitability of sophisticated molecular assays to assess the metastatic potential of primary breast carcinomas better than what is currently done; and the need for modifying the scoring criteria of the assays to assess tumor responsiveness to anti-HER2 treatments
Diagnostic and therapeutic management of carcinoma of unknown primary: Histopathological and molecular diagnosis
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Lymphoepithelial cysts of salivary glands: An immunohistochemical study of HIV-related and HIV-unrelated lesions
No full textAn indolent lesion of the salivary glands that mimics Sjogren syndrome has been repeatedly reported in HIV-infected (HIV+) patients. It is characterized by the occurrence, usually in the parotid gland, of variably sized lymphoepithelial cysts (LECs), whose origin is still unclear. We have compared the morphological and immunohistochemical features of six cases of LEC in HIV+ patients with those of five cases of LEC in HIV-negative (HIV-) patients. The results of the study show that LECs have similar histological and immunohistochemical features in both HIV+ and HIV-patients, and that they may simultaneously affect the salivary gland parenchyma and the intrasalivary lymph nodes. Furthermore, a diffuse lymphoid infiltrate is invariably observed in the glandular tissue around LECs and it is consistently associated with ectatic changes of the striated ducts. These data and the finding of an equivalent proliferation fraction of the epithelial compartment in both LEC and salivary retention cysts, used as controls for this study, are consistent with the hypothesis that cyst formation is secondary to the obstruction of salivary ducts by exuberant lymphoid infiltration. Copyright (C) 1998 by W.B. Saunders Company
Profile of buparlisib and its potential in the treatment of breast cancer: evidence to date [Corrigendum]
No full textCriscitiello C, Viale G, Curigliano G, et al. Profile ofbuparlisib and its potential in the treatment of breast cancer:evidence to date. Breast Cancer (Dove Med Press).2018;10:23–29.On page 23, Giuseppe Curigliano’s affiliation was incorrcectlylisted as European Institute of Oncology, Milan, Italy.It should be Department of Oncology and Hemato-Oncology,Division of Early Drug Development for Innovative Therapy,University of Milan, European Institute of Oncology, Milan,Italy.Read the original articl
Her2/neu (c-erb B2) nel carcinoma mammario: premesse biologiche e procedure di valutazione dell’espressione per uso clinico
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Metodiche per evidenziare le immunoglobuline di membrana dei linfociti per mezzo dell'immunofluorescenza
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