1,721,273 research outputs found
Role of peripheral blood mononuclear cell subsets of seronegative donors in HIV replication: Suppression by CD8(+) and CD16(+) cells and enhancement by CD14(+) monocytes
No full textA polymorphism of the interleukin-1 beta gene at position +3953 influences progression and neuro-pathological hallmarks of Alzheimer's disease.
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Myeloid cells in glioblastoma microenvironment
Full text linkGlioblastoma (GBM) is the most aggressive, malignant primary brain tumor in adults. GBM is notoriously resistant to immunotherapy mainly due to its unique immune microenvironment. High dimensional data analysis reveals the extensive heterogeneity of immune components making up the GBM microenvironment. Myeloid cells are the most predominant contributors to the GBM microenvironment; these cells are critical regulators of immune and therapeutic responses to GBM. Here, we will review the most recent advances on the characteristics and functions of different populations of myeloid cells in GBM, including bone marrow-derived macrophages, microglia, myeloid-derived suppressor cells, dendritic cells, and neutrophils. Epigenetic, metabolic, and phenotypic peculiarities of microglia and bone marrow-derived macrophages will also be assessed. The final goal of this review will be to provide new insights into novel therapeutic approaches for specific targeting of myeloid cells to improve the efficacy of current treatments in GBM patients
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Different effects of antihypertensive regimens based on fosinopril or hydrochlorothiazide with or without lipid lowering by pravastatin on progression of asymptomatic carotid atherosclerosis: principal results of PHYLLIS--a randomized double-blind trial.
No full text1. Stroke. 2004 Dec;35(12):2807-12. Epub 2004 Oct 28.
Different effects of antihypertensive regimens based on fosinopril or
hydrochlorothiazide with or without lipid lowering by pravastatin on progression
of asymptomatic carotid atherosclerosis: principal results of PHYLLIS--a
randomized double-blind trial.
Zanchetti A, Crepaldi G, Bond MG, Gallus G, Veglia F, Mancia G, Ventura A, Baggio
G, Sampieri L, Rubba P, Sperti G, Magni A; PHYLLIS Investigators.
Istituto Auxologico Italiano, Ospedale Maggiore, University of Milan, Italy.
[email protected]
BACKGROUND AND PURPOSE: The Plaque Hypertension Lipid-Lowering Italian Study
(PHYLLIS) tested whether (1) the angiotensin-converting enzyme (ACE) inhibitor
fosinopril (20 mg per day) was more effective on carotid atherosclerosis
progression than the diuretic hydrochlorothiazide (25 mg per day), (2)
pravastatin (40 mg per day) was more effective than placebo when added to either
hydrochlorothiazide or fosinopril, and (3) there were additive effects of ACE
inhibitor and lipid-lowering therapies.
METHODS: A total of 508 hypertensive, hypercholesterolemic patients with
asymptomatic carotid atherosclerosis were randomized to: (A) hydrochlorothiazide;
(B) fosinopril; (C) hydrochlorothiazide plus pravastatin; and (D) fosinopril plus
pravastatin, and followed up blindly for 2.6 years. B-Mode carotid scans were
performed yearly by certified sonographers in 13 hospitals and read centrally.
Corrections for drift were calculated from readings repeated at study end.
Primary outcome was change in mean maximum intima-media thickness of far and near
walls of common carotids and bifurcations bilaterally (CBM(max)).
RESULTS: CBM(max) significantly progressed (0.010+/-0.004 mm per year; P=0.01) in
group A (hydrochlorothiazide alone) but not in groups B, C, and D. CBM(max)
changes in groups B, C, and D were significantly different from changes in group
A. Changes in group A were concentrated at the bifurcations. "Clinic" and
"ambulatory" blood pressure reductions were not significantly different between
groups, but total and low-density lipoprotein cholesterol decreased by
approximately 1 mmol/L in groups C and D.
CONCLUSIONS: Progression of carotid atherosclerosis occurred with
hydrochlorothiazide but not with fosinopril. Progression could also be avoided by
associating pravastatin with hydrochlorothiazide.
PMID: 15514192 [PubMed - indexed for MEDLINE
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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