1,720,986 research outputs found
TWENTY YEARS OF NON-PEPTIDE CCK1 RECEPTOR ANTAGONISTS: ALL THAT GLITTERS IS NOT GOLD
No full textDuring the last 20 years, pharmaceutical industry and academic eforts have led to several structurally unrelated classes of non peptide cholecystokinin-1 receptor antagonista. Due to the lack of high resolution structure of CCK1-R and its peptide ligand, different strategies to design antagonists have been adopted
Synthesis and antitumor activity of aminoacid derivatives of the antimetastatic agent DM-COOK.
No full textSimultaneous determination of ionization constant and partition coefficient of DM-COOK, a potent antimetastatic agent.
No full textStability of the chemical xenogenization inducer, MM-COOK, possible metabolite of the antimetastatic agent, DM-COOK. A kinetic investigation.
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Antineoplastic action of p-(3-methyl-1-triazeno) benzoic acid potassium salt, monomethylderivative of the antimetastatic compound DM-COOK
No full text2D-QSAR and 3D-QSAR/CoMFA analyses of the N-terminal substituted anthranilic acid based CCK1 receptor antagonists: ‘Hic Rhodus, hic saltus’
No full textA research is presented on quantitative structure–activity relationship (QSAR) studies on the more recent class of non-peptidic CCK1 receptor antagonists. Our results suggest that the balance of hydrophobicity and volume dependent polarizability term plays a key role in the antagonism of CCK1 receptor
ANTHRANILIC ACID BASED CCK1 RECEPTOR ANTAGONISTS AND CCK-8 HAVE A COMMON STEP IN THEIR "RECEPTOR DESMODYNAMIC PROCESSES"
No full textThe interaction between the 1-47 N-terminus of the CCK1-R and the anthranilic acid based antagonists has been investigated by fluorescence spectroscopy. These antagonists interact with W39 of the N-terminal domain of the CCK1-R like that of the endogenous ligand CCK-8
The X-ray diffraction crystal structure determination and electron impact fragmentations of the gaseous ions of 3-(p-chlorophenyl)-1-methyltriazene-1-oxide and its 3-methyl derivative
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