1,721,022 research outputs found
Buccal and topical drug delivery
Full text linkThe aim of this work is to investigate new and classical techniques, methods and formulations for topical and buccal release. All the formulations proposed are based on natural and biocompatible polymer matrices such as gellan gum, scleroglucan and hydroxypropylmethylcellulose. The proposed formulations are tested by in vitro release tests. In fact they represents a valid support and a useful starting point for the realization of a potentially usable in-vivo pharmaceutical formulation that may have commercial utility. The research work is both experimental and theoretical. Each topic presents a more chemical-pharmaceutical part, based on the formulation preparation and release experiments, and a more theoretical-numerical approach that allows a correct interpretation and description of the experimental data obtained. Release from hydrogels and thin films require different modelling approaches. Also the physico-mathematical description of different release experiments (different release devices such as Franz cell, millifluidic device and USP II) requires different theoretical and numerical techniques. The outcome of an accurate model development is of fundamental importance for future design of pharmaceutical formulations with prescribed release properties. In addition the formulations are investigated through rheological, mechanical, thermoanalytic and mucoadhesive tests in order to have a more comprehensive picture of their practical utilization
Manufacturing and characterization of polymeric thin films for buccal delivery of drugs
No full textThis study aimed to explore film forming capacity of a natural
polysaccharide, gellan gum (GG), for fabrication of oral thin films
(OTFs) for the delivery of drugs [1]. For the development of
buccal film with ideal mechanical properties and adequate
amount of drug incorporated, concentration of polymer and
plasticizer were optimized to obtain films with the highest
standard in terms of flexibility and homogeneity [2]. Moreover,
attention was also paid to the exploration of opportune
dissolution tests able to discriminate the release profiles of drugs
from polymeric thin films
Thin film technology: new opportunity for buccal controlled delivery. MITO. Un viaggio tra liposomi e polisaccaridi-A journey through liposomes and polysaccharides. Ediz. bilingue
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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