1,720,978 research outputs found
The effect of anesthesia on hemodynamics and outcome of patients undergoing thrombectomy after acute ischemic stroke: a retrospective analysis
No full textBackground Anesthesia during thrombectomy remains a matter of debate. We retrospectively investigated the influence of intraprocedural blood pressure and type of anaesthetic agent on 3-month functional outcome and mortality in stroke patients undergoing mechanical thrombectomy under general anesthesia in a single center study.Methods All patients suffering from stroke who presented between January 2019 and July 2021 at Ziekenhuis Oost-Limburg Genk, Belgium and who received thrombectomy were included. Patient's characteristics and outcome data had been collected for benchmarking. Detailed perioperative data were exported from the electronic anesthesia records and clinically validated. Patients were stratified by peri-operative presence of hypotension (MAP = 65 mmHg).Results All 98 patients received mechanical thrombectomy under general anesthesia. Thirty-six percent (n = 35) was hypotensive peri-operatively at any time point. Proportion of sevoflurane use was higher in non-hypotensive patients compared to hypotensive patients (73% (n = 45) vs. 51% (n = 18), p = 0.04). Peri-operative use of vasopressors was higher in the hypotensive group compared to non-hypotensive (88% (n = 30) vs. 63% (n = 39), p = 0.008). Proportion of patients with good functional outcome at 3 months (mRS 0-2) was higher in non-hypotensive patients compared to hypotensive patients 44% (n = 27) vs. 24% (n = 8), p < 0.05. 90-day mortality was lower in non-hypotensive patients compared to hypotensive patients 21% (n = 13) vs. 43% (n = 15), (p = 0.02).Conclusion Patients who are hypotensive at any given time during thrombectomy under general anesthesia may have worse neurological outcome compared to non-hypotensive patients. The best anaesthetic management for mechanical thrombectomy needs to be clarified prospectively in large multicenter studies.We would like to thank all health care workers who helped with this study. Dr. Pieter Jan Van Asbroeck, Dr. Ruben Haesendonck, Dr. Cédric Van Dijck are greatly thanked for their assistance. The Stroke Consortium includes following collaborators who were directly involved in patient care of the study: Stockx Luc, MD3 , Ernon, Ludovic, MD4 ,Van Boxstael, Sam, MD1, Vanelderen, Pascal, MD, PhD1,5
Pre-ICU characteristics in cardiac surgery patients with CPB developing AKI
No full textAims. AKI is common after cardiac surgery involving CPB. Lack of reliable early detection methods for post-op AKI limits timely therapeutic intervention. A number of new biomarkers for AKI await validation in this setting. Analysis of a database was
performed to define baseline patient and biomarker characteristics in patients developing AKI.
Methods. 259 patients were enrolled. Patients with severe pre-existing renal insufficiency were excluded (eGFR<15ml/min). Urine and blood samples were obtained immediately before initiation of CPB. Patients were retrospectively divided into 2 groups,
AKI (n=84) and non-AKI (n=175), based on the AKIN criteria (increase in s-Creat ≥ 0.3 mg/dl or ≥ 50% compared to baseline within 48h or reduction in Urine output <0.5 ml/kg/h for more than 6h). Statistical analysis of all characteristics before arrival on the ICU was performed.
Results. AKI patients (32% of total) were older (70 yrs (SD= 9) vs 67 (11), p=0.043) with higher BMI’s (27.7 (4.8) vs. 26.7 (4.3), p=0.036). As to be expected baseline eGFR (CKD-EPI, in ml/min) was lower in the AKI-group (69.49 (20.30) vs. 76.45 (15.01), p=0.024). Both baseline urinary-NGAL (μg/l)(1211 (2172) vs. 749 (946), p=0.020) and serum-cystatin C (in mg/L)(0.98 (0.39) vs 0.86 (0.36), p=0.0175) were statistically higher in the AKI group and CPB time (in minutes) was significantly longer: 163 (63) vs 121 (51), p<0.0001.
Conclusion. u-NGAL and s-Cystatin most likely reflect pre-existing kidney dysfunction (like eGFR). CPB time is a significant factor for development of AKI, which is amenable to improvement
Pre-ICU characteristics in cardiac surgery patients with CPB developing AKI
No full textAims. AKI is common after cardiac surgery involving CPB. Lack of reliable early detection methods for post-op AKI limits timely therapeutic intervention. A number of new biomarkers for AKI await validation in this setting. Analysis of a database was
performed to define baseline patient and biomarker characteristics in patients developing AKI.
Methods. 259 patients were enrolled. Patients with severe pre-existing renal insufficiency were excluded (eGFR<15ml/min). Urine and blood samples were obtained immediately before initiation of CPB. Patients were retrospectively divided into 2 groups,
AKI (n=84) and non-AKI (n=175), based on the AKIN criteria (increase in s-Creat ≥ 0.3 mg/dl or ≥ 50% compared to baseline within 48h or reduction in Urine output <0.5 ml/kg/h for more than 6h). Statistical analysis of all characteristics before arrival on the ICU was performed.
Results. AKI patients (32% of total) were older (70 yrs (SD= 9) vs 67 (11), p=0.043) with higher BMI’s (27.7 (4.8) vs. 26.7 (4.3), p=0.036). As to be expected baseline eGFR (CKD-EPI, in ml/min) was lower in the AKI-group (69.49 (20.30) vs. 76.45 (15.01), p=0.024). Both baseline urinary-NGAL (μg/l)(1211 (2172) vs. 749 (946), p=0.020) and serum-cystatin C (in mg/L)(0.98 (0.39) vs 0.86 (0.36), p=0.0175) were statistically higher in the AKI group and CPB time (in minutes) was significantly longer: 163 (63) vs 121 (51), p<0.0001.
Conclusion. u-NGAL and s-Cystatin most likely reflect pre-existing kidney dysfunction (like eGFR). CPB time is a significant factor for development of AKI, which is amenable to improvement
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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