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    Longitudinal reference ranges for serial measurements of myocardial performance index (MPI) by conventional and tissue Doppler in monochorionic diamniotic pregnancies at 17–26 weeks of gestation

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    Objectives To establish longitudinal reference ranges for fetal MPI measured by conventional Doppler (MPI) and by tissue Doppler (MPI') based on a prospective cohort of uncomplicated MCDA twin. Methods Single-centre observational study. We measured MPI and MPI' on the right and left ventricles three times between 17and 26 weeks of gestation. Second-degree fractional polynomials were used to obtain the best fitting curves in relation to gestational age (weeks) for each parameter. Multilevel modelling was used to estimate the reference percentiles. Appropriate back transformations were performed to obtain the gestational age-specific reference values. Results Eighty-three uncomplicated MCDA pregnancies were included in our study with a total of 249 observations. Fetal cardiac function was measured as MPI RV and LV, MPI' RV and LV at a mean gestational age of 18.3 (range 17.1-19.2), 22.3 (21.1-23.5) and 24.3 (22.6-26.2) weeks. The reference ranges for MPI LV, MPI RV, MPI' LV, MPI' RV at 18–24 weeks were constructed. Conclusions The present study provides additional data on fetal cardiac function in uncomplicated MCDA twin gestations, describing the evolution of novel parameters in both ventricles

    Effects of epidural analgesia on uterine artery Doppler in labour.

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    abstract Ultrasound in Obstetrics and Gynecology. Volume 34, Issue 0, Date: September 2009, Pages: 9

    Interobserver repeatability of transabdominal 3D ultrasound of the fetal brain.

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    abstract Ultrasound in Obstetrics and Gynecology. Volume 34, Issue 0, Date: September 2009, Pages: 196-19

    Outcome of monochorionic diamniotic twin pregnancies followed at a single center

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    OBJECTIVE: We aim to evaluate the outcome of a cohort of monochorionic diamniotic twin pregnancies followed from the first trimester onwards at a single center. METHOD: This was a retrospective analysis of prospectively collected data from a series of 300 monochorionic diamniotic twin pregnancies referred to our twin clinic between 2001 and 2012. Pregnancies were followed from the first trimester and fortnightly after 16 weeks of gestation. Data on pregnancy and neonatal outcome were analyzed. RESULTS: There were two surviving infants in 259/300 (86.4%) pregnancies, one survivor in 22/300 (7.3%) and no survivors in 19/300 (6.3%) with an overall mortality of 60/600 (10%). Twin-twin transfusion syndrome was diagnosed in 33 cases (11%), isolated intertwin weight discordance ≥ 25% in 35 (11.6%) and major congenital structural anomalies in ten (3.3%). After 32 weeks, the prospective risk of spontaneous fetal intrauterine death was one in 248 (0.4%) per pregnancy. CONCLUSIONS: Despite specific prenatal fetal monitoring and management, monochorionic diamniotic twin pregnancies have still to be considered at high risk of mortality, although the prospective risk of intrauterine death after 32 weeks is low. Twin-twin transfusion syndrome and congenital anomalies were the main risk factors for mortalit
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