1,720,959 research outputs found
Efficacy of enzyme replacement therapy over six-months in a non-classic infantile Pompe disease form: our experience in a 2-year-old affected child
No full textHeart disease and inborn errors of metabolism: prevalence, manifestations and correlation with the specific ongoing treatment in 42 patients followed at San Paolo Hospital, Milan
No full textBone mineral density (BMD) in patients affected by hyperphenylalanynemia (HPA) : effects of calcium integration and physical activity evaluated with dual energy x-ray absorptiometry (DEXA)
No full textDensità minerale ossea (BMD) nei pazienti affetti da iperfenilalaninemia (HPA): ruolo della supplementazione con calcio e dell'attività fisica
No full textScopo: Diversi studi hanno evidenziato un difetto di mineralizzazione ossea in pazienti affetti da HPA. Lo scopo del nostro studio è stato valutare la BMD in un campione di pazienti affetti da HPA ed osservare l'effetto dell'integrazione di calcio e dell'attività fisica. Pazienti e metodi: Sono stati considerati 117 pazienti affetti da HPA a dieta libera ed in dietoterapia suddivisi in base alla compliance dietetica, all'integrazione calcica e alla pratica di attività fisica per l'analisi della BMD; 29 pazienti assumevano un'integrazione con calcio; mediante DEXA è stata esaminata la BMD in L1-L4, lo Z-score BMD ed il contenuto di massa osseo; è stato calcolato il BMI e lo Z-score BMI e sono stati dosati a livello plasmatico fenilalanina, calcio, fosforo, magnesio e fosfatasi alcalina. Risultati: La differenza tra lo Z-score BMD dei pazienti in dietoterapia e a dieta libera è risultata statisticamente significativa, in particolare per il gruppo con buona compliance dietetica (p=0,0025) rispetto a quello con scarsa compliance dietetica (p>0,05). Non è stata evidenziata una relazione lineare tra BMD e fenilalanina (R2=0,025). Lo Z-score BMD e gli indici ematici analizzati hanno mostrato un miglioramento dopo 12 mesi di integrazione con calcio. Tra i pazienti che praticano attività fisica, non è stata evidenziata una differenza statisticamente significativa tra pazienti a dieta libera e pazienti in dietoterapia integrati con calcio; il praticare unicamente attività fisica si associa a uno Z-score BMD lievemente ridotto rispetto alla sola integrazione di calcio. Conclusioni: La presente analisi ha mostrato una riduzione della BMD nei pazienti affetti da HPA in dietoterapia; una dieta restrittiva sembra essere associata ad una ridotta mineralizzazione ossea. La dietoterapia associata ad una adeguata integrazione calcica e a regolare attività fisica potrebbe quindi prevenire il rischio di osteopenia e/o osteoporosi a lungo termine
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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