655 research outputs found
Comparative analysis of www pages of czech universities
No full textCílem této bakalářské práce je analýza a porovnání celkové úrovně webových prezentací vybraných vysokých škol v České republice. V této analýze se porovnává na základě 15 kritérií následujících šest českých vysokých škol: Karlova univerzita v Praze, Masarykova univerzita v Brně, ČVUT Praha, Vysoké učení technické Brno, Západočeská univerzita v Plzni a Vysoká škola ekonomická v Praz
CleanEx: a database of heterogeneous gene expression data based on a consistent gene nomenclature
No full textThe main goal of CleanEx is to provide access to public gene expression data via unique gene names. A second objective is to represent heterogeneous expression data produced by different technologies in a way that facilitates joint analysis and cross-data set comparisons. A consistent and up-to-date gene nomenclature is achieved by associating each single experiment with a permanent target identifier consisting of a physical description of the targeted RNA population or the hybridization reagent used. These targets are then mapped at regular intervals to the growing and evolving catalogues of human genes and genes from model organisms. The completely automatic mapping procedure relies partly on external genome information resources such as UniGene and RefSeq. The central part of CleanEx is a weekly built gene index containing cross-references to all public expression data already incorporated into the system. In addition, the expression target database of CleanEx provides gene mapping and quality control information for various types of experimental resource, such as cDNA clones or Affymetrix probe sets. The web-based query interfaces offer access to individual entries via text string searches or quantitative expression criteria. CleanEx is accessible at: http://www.cleanex.isb-sib.ch/.GR-BUCHERSwiss Insitiute of Bioinformatics, Ch. des Boveresses 155, 1066 Epalinges s/Lausanne, Switzerland
News and announcements
No full textsummary:Křížek, M., Trolingová, Z.: Profesor Beloslav Riečan získal v Karoline čestný doktorát
Prejav Beloslava Riečana v Prahe dňa 4. apríla 2012 pri preberaní titulu doctor honoris causa Univerzity Karlovej
Zimmermann, K.: Prof. RNDr. Jiří Rohn, DrSc., pětašedesátiletý
Pravda, V.: Mezinárodní konference ke stému výročí působení Alberta Einsteina v Praz
Splicy: a web-based tool for the prediction of possible alternative splicing events from Affymetrix probeset data
No full textBACKGROUND: The Affymetrix technology is nowadays a well-established method for the analysis of gene expression profiles in cancer research studies. However, changes in gene expression levels are not the only way to link genes and disease. The existence of gene isoforms specifically linked with cancer or apoptosis is increasingly found in literature. Hence it is of great interest to associate the results of a gene expression study with updated evidences on the transcript structure and its possible variants. RESULTS: We present here a web-based software tool, Splicy, whose primary task is to retrieve data on the mapping of Affymetrix probes to single exons of gene transcripts and displaying graphically this information projected on the gene physical structure.Starting from a list of Affymetrix probesets the program produces a series of graphical displays, each relative to a transcript associated with the gene targeted by a given probe. The information on the transcript-by-transcript and exon-by-exon mapping of probe pairs can be retrieved both graphically and in the form of tab-separated files. The mapping of single probes to NCBI RefSeq or EMBL cDNAs is handled by the ISREC mapping tables used in the CleanEx Expression Reference Database Project. We currently maintain these mappings for most popular human and mouse Affymetrix chips, and Splicy can be queried for matches with human and mouse NCBI RefSeq or EMBL cDNAs. CONCLUSION: Splicy generates probeset annotations and images describing the relation between the single probes and intron/exon structure of the target transcript in all its known variants. We think that Splicy will be useful for giving to the researcher a clearer picture of the possible transcript variants linked with a given gene and an additional view on the interpretation of microarray experiment data. Splicy is publicly available and has been realized in the framework of a bioinformatics grant from the Italian Cancer Research Association.GR-BUCHE
CleanEx: new data extraction and merging tools based on MeSH term annotation
No full textThe CleanEx expression database (http://www.cleanex.isb-sib.ch) provides access to public gene expression data via unique gene names as well as via experiments biomedical characteristics. To reach this, a dual annotation of both sequences and experiments has been generated. First, the system links official gene symbols to any kind of sequences used for gene expression measurements (cDNA, Affymetrix, oligonucleotide arrays, SAGE or MPSS tags, Expressed Sequence Tags or other mRNA sequences, etc.). For the biomedical annotation, we re-annotate each experiment from the CleanEx database with the MeSH (Medical Subject Headings) terms, primarily used by NLM (National Library of Medicine) for indexing articles for the MEDLINE/PubMED database. This annotation allows a fast and easy retrieval of expression data with common biological or medical features. The numerical data can then be exported as matrix-like tab-delimited text files. Data can be extracted from either one dataset or from heterogeneous datasets.GR-BUCHE
Marius the Epicurean, Walter the Medusean : Praz’s Paterian (Self-)Fashioning
No full textMario Praz not only introduced the study of Walter Pater to Italian culture and developed an early but lifelong interest in him, but also saw in the English author an in-absentia mentor for his own literary education and fashioning of himself as an artist and culture maven. Throughout Praz’s career, Pater represented a model for the discriminating critic, the aesthete and art lover, always susceptible to the unexpected element in beauty. It was possibly Pater, more than any other artist, philosopher or thinker, who provided Praz with the principles of his criticism and aesthetics. The essay explores the distinctive traits of Praz’s work that may reveal appropriations from Pater, while also considering more personal aspects of his figure that entail Paterian influence. It also illustrates how Praz’s emulation of the master was a long and intricate process, which involved at times misunderstandings and prejudices not so dissimilar from the misreadings of the previous Italian scholars of English literature Praz was so anxious to refute in order to claim the role of founder of English studies in Italy for himself
Comparative analysis of www pages of czech universities
No full textCílem této bakalářské práce je analýza a porovnání celkové úrovně webových prezentací vybraných vysokých škol v České republice. V této analýze se porovnává na základě 15 kritérií následujících šest českých vysokých škol: Karlova univerzita v Praze, Masarykova univerzita v Brně, ČVUT Praha, Vysoké učení technické Brno, Západočeská univerzita v Plzni a Vysoká škola ekonomická v Praz
The Eukaryotic Promoter Database, EPD: new entry types and links to gene expression data
No full textThe Eukaryotic Promoter Database (EPD) is an annotated, non-redundant collection of eukaryotic Pol II promoters, for which the transcription start site has been determined experimentally. Access to promoter sequences is provided by pointers to positions in nucleotide sequence entries. The annotation part of an entry includes a description of the initiation site mapping data, exhaustive cross-references to the EMBL nucleotide sequence database, SWISS-PROT, TRANSFAC and other databases, as well as bibliographic references. EPD is structured in a way that facilitates dynamic extraction of biologically meaningful promoter subsets for comparative sequence analysis. World Wide Web-based interfaces have been developed which enable the user to view EPD entries in different formats, to select and extract promoter sequences according to a variety of criteria, and to navigate to related databases exploiting different cross-references. The EPD web site also features yearly updated base frequency matrices for major eukaryotic promoter elements. EPD can be accessed at http://www.epd.isb-sib.ch.GR-BUCHERSwiss Institute of Bioinformatics and Swiss Institute for Experimental Cancer Research, Ch. des Boveresses 155, 1066-Epalinges s/Lausanne, Switzerland
Dějiny umění národa českého: S četnými původními illustracemi a barvotiskovými přílohami Sešit 74,75
No full textStav: 3Místo vydání: V Praz
- …
